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MedKoo Cat#: 599083 | Name: Cinodine II

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Cinodine II is a broad spectrum antibiotic.

Chemical Structure

Cinodine II
Cinodine II
CAS#60830-75-3 (II)

Theoretical Analysis

MedKoo Cat#: 599083

Name: Cinodine II

CAS#: 60830-75-3 (II)

Chemical Formula: C37H59N13O13

Exact Mass: 893.4355

Molecular Weight: 893.95

Elemental Analysis: C, 49.71; H, 6.65; N, 20.37; O, 23.27

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
68782-58-1 (HCl) 60830-75-3 (II) 60830-76-4 (I) 52932-64-6 (free base)
Synonym
Cinodine II; LL-BM123 gamma, (Z)-; Antibiotic LL-BM123 gamma, (Z)-; LL-BMgamma2;
IUPAC/Chemical Name
(E)-N-(3-((4-aminobutyl)amino)propyl)-3-(4-(((2R,3R,4S,5S,6R)-3-guanidino-4-hydroxy-5-(3-((2S,3R,4R,5R)-4-hydroxy-5-(((3aS,6S,7R,7aR)-2-oxo-7-ureidohexahydro-2H-pyrano[4,3-d]oxazol-6-yl)oxy)-3-ureidotetrahydro-2H-pyran-2-yl)ureido)-6-methyltetrahydro-2H-pyran-2-yl)oxy)phenyl)acrylamide
InChi Key
JFKMOESWBQOEER-DXFZHRLCSA-N
InChi Code
InChI=1S/C37H59N13O13/c1-17-23(29(53)27(45-33(39)40)32(60-17)61-19-8-5-18(6-9-19)7-10-22(51)44-14-4-13-43-12-3-2-11-38)48-36(56)50-30-26(47-35(42)55)28(52)21(16-58-30)62-31-25(46-34(41)54)24-20(15-59-31)63-37(57)49-24/h5-10,17,20-21,23-32,43,52-53H,2-4,11-16,38H2,1H3,(H,44,51)(H,49,57)(H4,39,40,45)(H3,41,46,54)(H3,42,47,55)(H2,48,50,56)/b10-7+/t17-,20-,21-,23-,24+,25-,26-,27-,28+,29+,30+,31+,32-/m1/s1
SMILES Code
O=C(NCCCNCCCCN)/C=C/C1=CC=C(O[C@@H]2[C@H](NC(N)=N)[C@@H](O)[C@H](NC(N[C@@H]3[C@H](NC(N)=O)[C@@H](O)[C@H](O[C@H]4[C@H](NC(N)=O)[C@@]5([H])NC(O[C@]5([H])CO4)=O)CO3)=O)[C@@H](C)O2)C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 893.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen RH, Whittern DN, Buko AM, McAlpine JB. Coumamidines, new broad spectrum antibiotics of the cinodine type. II. Isolation and structural elucidation. J Antibiot (Tokyo). 1989 Apr;42(4):533-7. PubMed PMID: 2498267. 2: Osburne MS, Maiese WM, Greenstein M. In vitro inhibition of bacterial DNA gyrase by cinodine, a glycocinnamoylspermidine antibiotic. Antimicrob Agents Chemother. 1990 Jul;34(7):1450-2. PubMed PMID: 2167040; PubMed Central PMCID: PMC176000. 3: Osburne MS. Characterization of a cinodine-resistant mutant of Escherichia coli. J Antibiot (Tokyo). 1995 Nov;48(11):1359-61. PubMed PMID: 8557583. 4: Hooper DC. Bacterial topoisomerases, anti-topoisomerases, and anti-topoisomerase resistance. Clin Infect Dis. 1998 Aug;27 Suppl 1:S54-63. Review. PubMed PMID: 9710672.