Synonym
Griffonin; Lithospermoside; Griffonia simplicifolia extracts; NSC 290807; NSC-290807; NSC290807;
IUPAC/Chemical Name
(Z)-2-((4R,5S,6S)-4,5-dihydroxy-6-(((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)cyclohex-2-en-1-ylidene)acetonitrile
InChi Key
WIIDBJNWXCWLKF-VVAXPEBGSA-N
InChi Code
InChI=1S/C14H19NO8/c15-4-3-6-1-2-7(17)9(18)13(6)23-14-12(21)11(20)10(19)8(5-16)22-14/h1-3,7-14,16-21H,5H2/b6-3-/t7-,8-,9+,10-,11+,12-,13+,14+/m1/s1
SMILES Code
N#C/C=C([C@@H]1O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)/C=C[C@@H](O)[C@@H]1O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
329.30
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Larmie ET, Poston L. The in vitro effects of griffonin and ouabain on erythrocyte sodium content obtained from normal subjects and sickle cell patients. Planta Med. 1991 Apr;57(2):116-8. PubMed PMID: 1891492.
2: Dwuma-Badu D. Constituents of West African medicinal plants. XVI. Griffonin and Grriffonilide, novel constituents of Griffonia simplicifolia. Lloydia. 1976 Nov-Dec;39(6):385-90. PubMed PMID: 1026839.
3: Mazimba O, Majinda RR, Modibedi C, Masesane IB, Cencič A, Chingwaru W. Tylosema esculentum extractives and their bioactivity. Bioorg Med Chem. 2011 Sep 1;19(17):5225-30. doi: 10.1016/j.bmc.2011.07.006. Epub 2011 Jul 14. PubMed PMID: 21813280.
4: Han QB, Jiang B, Mei SX, Ding G, Sun HD, Xie JX, Liu YZ. Constituents from the roots of Semiaquilegia adoxoides. Fitoterapia. 2001 Jan;72(1):86-8. PubMed PMID: 11163952.
5: Puolakkainen PA, Reed MJ, Gombotz WR, Twardzik DR, Abrass IB, Sage HE. Acceleration of wound healing in aged rats by topical application of transforming growth factor-beta(1). Wound Repair Regen. 1995 Jul-Sep;3(3):330-9. PubMed PMID: 17173560.
