Synonym
ICI-185282; ICI 185282; ICI185282;
IUPAC/Chemical Name
(Z)-7-[(2S,4S,5R)-4-(2-Hydroxyphenyl)-2-(trifluoromethyl)-1,3-dioxan-5-yl]hept-5-enoic acid
InChi Key
ZWAVGFSZMACJHA-PMNBYGLBSA-N
InChi Code
InChI=1S/C18H21F3O5/c19-18(20,21)17-25-11-12(7-3-1-2-4-10-15(23)24)16(26-17)13-8-5-6-9-14(13)22/h1,3,5-6,8-9,12,16-17,22H,2,4,7,10-11H2,(H,23,24)/b3-1-/t12-,16+,17+/m1/s1
SMILES Code
O=C(O)CCC/C=C\C[C@H]1[C@@H](C2=CC=CC=C2O)O[C@@H](C(F)(F)F)OC1
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
374.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Westwood FR, Duffy PA, Malpass DA, Jones HB, Topham JC. Disturbance of macrophage and monocyte function in the dog by a thromboxane receptor antagonist: ICI 185,282. Toxicol Pathol. 1995 May-Jun;23(3):373-84. PubMed PMID: 7659959.
2: Kanzik I, Zengil H, Ipek N, Cakici I, Abacioglu N, Dörtlemez H. Synergism between UK 38485 and ICI 185282 against digoxin-induced arrhythmias in guinea-pigs. Arch Int Pharmacodyn Ther. 1991 Jul-Aug;312:55-65. PubMed PMID: 1772341.
3: Taylor A, Williams DA, Wilson ID. Derivatized beta-cyclodextrins combined with high field NMR for enantiomer analysis: application to ICI 185,282 (5(Z)-7- ([2RS,4RS,5SR]-4-o-hydroxyphenyl-2-trifluoromethyl-1,3-dioxan-5-yl) heptenoic acid). J Pharm Biomed Anal. 1991;9(6):493-6. PubMed PMID: 1747402.
4: Kanzik I, Demiryürek AT, Zengil H, Abacioğlu N, Dörtlemez H. Effects of thromboxane synthetase inhibitor (UK 38,485) and thromboxane receptor antagonist (ICI 185,282) on digoxin-induced arrhythmias in anaesthetized guinea-pigs. Clin Exp Pharmacol Physiol. 1988 Dec;15(12):927-35. PubMed PMID: 3243019.
5: Birch J, Brown E, Calnan C, Jessup CL, Jessup R, Wayne M. Studies in the guinea-pig with ICI 185,282: a thromboxane A2 receptor antagonist. J Pharm Pharmacol. 1988 Oct;40(10):706-10. PubMed PMID: 2907537.
6: Swayne GT, Maguire J, Dolan J, Raval P, Dane G, Greener M, Owen DA. Evidence for homogeneity of thromboxane A2 receptor using structurally different antagonists. Eur J Pharmacol. 1988 Aug 2;152(3):311-9. PubMed PMID: 2975605.
