Synonym
Buthiobate; Butiobate; Denmert; S 1358; S-1358; S1358;
IUPAC/Chemical Name
butyl (4-(tert-butyl)benzyl) (E)-pyridin-3-ylcarbonimidodithioate
InChi Key
ZZVVDIVWGXTDRQ-BSYVCWPDSA-N
InChi Code
InChI=1S/C21H28N2S2/c1-5-6-14-24-20(23-19-8-7-13-22-15-19)25-16-17-9-11-18(12-10-17)21(2,3)4/h7-13,15H,5-6,14,16H2,1-4H3/b23-20+
SMILES Code
CCCCS/C(SCC1=CC=C(C(C)(C)C)C=C1)=N\C2=CC=CN=C2
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
372.58
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yoshida Y, Aoyama Y. Effects of buthiobate, a fungicide, on cytochrome P-450 of rat liver microsomes. J Pharmacobiodyn. 1985 Jun;8(6):432-9. PubMed PMID: 4057038.
2: Aoyama Y, Yoshida Y, Hata S, Nishino T, Katsuki H. Buthiobate: a potent inhibitor for yeast cytochrome P-450 catalyzing 14 alpha-demethylation of lanosterol. Biochem Biophys Res Commun. 1983 Sep 15;115(2):642-7. PubMed PMID: 6414474.
3: Aoyama Y, Yoshida Y, Hata S, Nishino T, Katsuki H, Maitra US, Mohan VP, Sprinson DB. Altered cytochrome P-450 in a yeast mutant blocked in demethylating C-32 of lanosterol. J Biol Chem. 1983 Aug 10;258(15):9040-2. PubMed PMID: 6409899.
4: Aaberg AM, Larsen CE, Rasmussen BS, Hansen CM, Larsen JM. Basic life support knowledge, self-reported skills and fears in Danish high school students and effect of a single 45-min training session run by junior doctors; a prospective cohort study. Scand J Trauma Resusc Emerg Med. 2014 Apr 14;22:24. doi: 10.1186/1757-7241-22-24. PubMed PMID: 24731392; PubMed Central PMCID: PMC4022325.
5: Boogaard A, Griffioen M, Cohen LH. Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in human hepatoma cell line Hep G2. Effects of inhibitors of cholesterol synthesis on enzyme activity. Biochem J. 1987 Jan 15;241(2):345-51. PubMed PMID: 3036060; PubMed Central PMCID: PMC1147567.
6: Nakanishi S, Nishino T, Yabusaki Y, Fujisaki S, Katsuki H. Preparation of 14C-labeled and unlabeled sterol intermediates from yeast using metabolic inhibitors. J Biochem. 1984 Dec;96(6):1665-72. PubMed PMID: 6397465.
7: Hata S, Nishino T, Katsuki H, Aoyama Y, Yoshida Y. Two species of cytochrome P-450 involved in ergosterol biosynthesis of yeast. Biochem Biophys Res Commun. 1983 Oct 14;116(1):162-6. PubMed PMID: 6357195.
