FTY720-Mitoxy | CAS#1604816-11-6 | PP2A stimulator

MedKoo Cat#: 562931 | Name: FTY720-Mitoxy

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FTY720-Mitoxy is a FTY720 analog that acts as a novel stimulator of the activity of the protein phosphatase 2A (PP2A), targeting mitochondria.

Chemical Structure

FTY720-Mitoxy

CAS#1604816-11-6

Theoretical Analysis

MedKoo Cat#: 562931

Name: FTY720-Mitoxy

CAS#: 1604816-11-6

Chemical Formula: C40H51BrNO3P

Exact Mass: 703.2790

Molecular Weight: 704.72

Elemental Analysis: C, 68.17; H, 7.29; Br, 11.34; N, 1.99; O, 6.81; P, 4.40

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

FTY720-Mitoxy; FTY720 Mitoxy; FTY720Mitoxy; FTY-720-Mitoxy; FTY 720 Mitoxy;

IUPAC/Chemical Name

(3-((1-hydroxy-2-(hydroxymethyl)-4-(4-octylphenyl)butan-2-yl)amino)-3-oxopropyl)triphenylphosphonium bromide

InChi Key

QKRJUTPJMQBOLJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C40H50NO3P.BrH/c1-2-3-4-5-6-10-17-34-24-26-35(27-25-34)28-30-40(32-42,33-43)41-39(44)29-31-45(36-18-11-7-12-19-36,37-20-13-8-14-21-37)38-22-15-9-16-23-38;/h7-9,11-16,18-27,42-43H,2-6,10,17,28-33H2,1H3;1H

SMILES Code

CCCCCCCCC1=CC=C(CCC(NC(CC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=O)(CO)CO)C=C1.[Br-]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>2 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 704.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Segura-Ulate I, Belcher TK, Vidal-Martinez G, Vargas-Medrano J, Perez RG. FTY720-derivatives do not induce FTY720-like lymphopenia. J Pharmacol Sci. 2017 Mar;133(3):187-189. doi: 10.1016/j.jphs.2017.02.006. Epub 2017 Feb 17. PubMed PMID: 28363412. 2: Enoru JO, Yang B, Krishnamachari S, Villanueva E, DeMaio W, Watanyar A, Chinnasamy R, Arterburn JB, Perez RG. Preclinical Metabolism, Pharmacokinetics and In Vivo Analysis of New Blood-Brain-Barrier Penetrant Fingolimod Analogues: FTY720-C2 and FTY720-Mitoxy. PLoS One. 2016 Sep 9;11(9):e0162162. doi: 10.1371/journal.pone.0162162. eCollection 2016. PubMed PMID: 27611691; PubMed Central PMCID: PMC5017749. 3: Vargas-Medrano J, Krishnamachari S, Villanueva E, Godfrey WH, Lou H, Chinnasamy R, Arterburn JB, Perez RG. Novel FTY720-Based Compounds Stimulate Neurotrophin Expression and Phosphatase Activity in Dopaminergic Cells. ACS Med Chem Lett. 2014 May 27;5(7):782-6. doi: 10.1021/ml500128g. eCollection 2014 Jul 10. PubMed PMID: 25050165; PubMed Central PMCID: PMC4094248.