Synonym
Meladrazine; Lisidonil; NSC 99857; NSC-99857; NSC99857;
IUPAC/Chemical Name
(E)-N2,N2,N4,N4-tetraethyl-6-hydrazono-1,6-dihydro-1,3,5-triazine-2,4-diamine
InChi Key
IRQOBYXMACIFKD-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H23N7/c1-5-17(6-2)10-13-9(16-12)14-11(15-10)18(7-3)8-4/h5-8,12H2,1-4H3,(H,13,14,15,16)
SMILES Code
CCN(C1=NC(N(CC)CC)=N/C(N1)=N/N)CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
253.35
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Zhang Y, Zhu J, Yin H, Marrero J, Zhang XX, Lubman DM. ESI-LC-MS Method for Haptoglobin Fucosylation Analysis in Hepatocellular Carcinoma and Liver Cirrhosis. J Proteome Res. 2015 Dec 4;14(12):5388-95. doi: 10.1021/acs.jproteome.5b00792. Epub 2015 Nov 3. PubMed PMID: 26503433; PubMed Central PMCID: PMC4670582.
2: Beisland HO, Fossberg E. The effects of terodiline and meladrazine on severe motor urge incontinence in geriatric patients. J Am Geriatr Soc. 1985 Jan;33(1):29-32. PubMed PMID: 3880780.
3: Hebjorn S. Treatment of detrusor hyperreflexia in multiple sclerosis: a double-blind, crossover clinical trial comparing methantheline bromide (Banthine), flavoxate chloride (Urispas) and meladrazine tartrate (Lisidonil). Urol Int. 1977;32(2-3):209-17. PubMed PMID: 20683.
4: Yin H, Zhu J, Wu J, Tan Z, An M, Zhou S, Mechref Y, Lubman DM. A procedure for the analysis of site-specific and structure-specific fucosylation in alpha-1-antitrypsin. Electrophoresis. 2016 Oct;37(20):2624-2632. doi: 10.1002/elps.201600176. Epub 2016 Sep 5. PubMed PMID: 27439567; PubMed Central PMCID: PMC5068566.
5: Diding E, Sandström H, Ostelius J, Karlén B, Bogentoft C. Studies on the application of integrated gas chromatography-mass spectrometry in drug purity control. Impurities in clofibrate, norethindrone, methandienone, haloperidol and meladrazine. Acta Pharm Suec. 1976;13(1):55-64. PubMed PMID: 1258663.
6: Nicholas RS, Friede T, Hollis S, Young CA. Anticholinergics for urinary symptoms in multiple sclerosis. Cochrane Database Syst Rev. 2009 Jan 21;(1):CD004193. doi: 10.1002/14651858.CD004193.pub2. Review. Update in: Cochrane Database Syst Rev. 2015;6:CD004193. PubMed PMID: 19160231.
