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MedKoo Cat#: 598976 | Name: Liquiritin apioside

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Liquiritin apioside is one of the main active components in Suan-Zao-Ren decoction as a treatment for insomnia.

Chemical Structure

Liquiritin apioside
CAS#74639-14-8

Theoretical Analysis

MedKoo Cat#: 598976

Name: Liquiritin apioside

CAS#: 74639-14-8

Chemical Formula: C26H30O13

Exact Mass: 550.1686

Molecular Weight: 550.51

Elemental Analysis: C, 56.73; H, 5.49; O, 37.78

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Liquiritin apioside;
IUPAC/Chemical Name
(S)-2-(4-(((2S,3R,4S,5S,6R)-3-(((2S,3R,4R)-3,4-dihydroxy-4-(hydroxymethyl)tetrahydrofuran-2-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)phenyl)-7-hydroxychroman-4-one
InChi Key
FTVKHUHJWDMWIR-DWMQJYMWSA-N
InChi Code
InChI=1S/C26H30O13/c27-9-19-20(31)21(32)22(39-25-23(33)26(34,10-28)11-35-25)24(38-19)36-14-4-1-12(2-5-14)17-8-16(30)15-6-3-13(29)7-18(15)37-17/h1-7,17,19-25,27-29,31-34H,8-11H2/t17-,19+,20+,21-,22+,23-,24+,25-,26+/m0/s1
SMILES Code
O=C(c1c(O2)cc(O)cc1)C[C@H]2c3ccc(O[C@H]4[C@H](O[C@H]5[C@H](O)[C@](CO)(O)CO5)[C@@H](O)[C@H](O)[C@@H](CO)O4)cc3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 550.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice. Biol Pharm Bull. 2011;34(9):1438-42. PubMed PMID: 21881230. 5: Wu YP, Meng XS, Bao YR, Wang S, Kang TG. Simultaneous quantitative determination of nine active chemical compositions in traditional Chinese medicine Glycyrrhiza by RP-HPLC with full-time five-wavelength fusion method. Am J Chin Med. 2013;41(1):211-9. doi: 10.1142/S0192415X13500158. PubMed PMID: 23336517. 6: Kamei J, Nakamura R, Ichiki H, Kubo M. Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang). Eur J Pharmacol. 2003 May 23;469(1-3):159-63. PubMed PMID: 12782198. 7: Liu X, Li Q, Lv C, Du Y, Xu H, Wang D, Li M, Li B, Li J, Bi K. Combination of the advantages of chromatographic methods based on active components for the quality evaluation of licorice. J Sep Sci. 2015 Dec;38(24):4180-6. doi: 10.1002/jssc.201500770. Epub 2015 Nov 19. PubMed PMID: 26472171. 8: Kamei J, Saitoh A, Asano T, Nakamura R, Ichiki H, Iiduka A, Kubo M. Pharmacokinetic and pharmacodynamic profiles of the antitussive principles of Glycyrrhizae radix (licorice), a main component of the Kampo preparation Bakumondo-to (Mai-men-dong-tang). Eur J Pharmacol. 2005 Jan 10;507(1-3):163-8. Epub 2004 Dec 22. PubMed PMID: 15659306. 9: Li G, Nikolic D, van Breemen RB. Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS. J Agric Food Chem. 2016 Oct 4. [Epub ahead of print] PubMed PMID: 27696846; PubMed Central PMCID: PMC5378676. 10: Guo M, Zhang YF, Wang Y, Zhao XP. [Development of a rapid screening method for discovering neuroprotective components from traditional Chinese medicine]. Zhongguo Zhong Yao Za Zhi. 2013 May;38(10):1581-4. Chinese. PubMed PMID: 23947142. 11: Lee KK, Omiya Y, Yuzurihara M, Kase Y, Kobayashi H. Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. J Ethnopharmacol. 2013 Jan 9;145(1):286-93. doi: 10.1016/j.jep.2012.11.005. Epub 2012 Nov 17. Erratum in: J Ethnopharmacol. 2013 Mar 7;146(1):431. PubMed PMID: 23164761. 12: Huang WW, Wang MY, Shi HM, Peng Y, Peng CS, Zhang M, Li Y, Lu J, Li XB. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. Arch Pharm Res. 2012 Nov;35(11):1945-52. doi: 10.1007/s12272-012-1111-x. Epub 2012 Dec 4. Erratum in: Arch Pharm Res. 2013 May;36(5):649. PubMed PMID: 23212636. 13: Kuang Y, He B, DU Y, Li J, Wang D, Bi K, Li Q. Simultaneous Determinations of Eleven Bioactive Components in Suanzaoren Decoction Granules by High-Performance Liquid Chromatography and Its Application to the Quality Control in Productive Processes. Anal Sci. 2016;32(9):931-6. doi: 10.2116/analsci.32.931. PubMed PMID: 27682396. 14: Dai JY, Yang JL, Li C. Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers. Acta Pharmacol Sin. 2008 Sep;29(9):1086-93. doi: 10.1111/j.1745-7254.2008.00850.x. PubMed PMID: 18718184. 15: Tsukamoto S, Aburatani M, Yoshida T, Yamashita Y, El-Beih AA, Ohta T. CYP3A4 inhibitors isolated from Licorice. Biol Pharm Bull. 2005 Oct;28(10):2000-2. PubMed PMID: 16204965. 16: Kondo K, Shiba M, Nakamura R, Morota T, Shoyama Y. Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information. Biol Pharm Bull. 2007 Jul;30(7):1271-7. PubMed PMID: 17603166. 17: Jiang Z, Wang Y, Zheng Y, Yang J, Zhang L. Ultra high performance liquid chromatography coupled with triple quadrupole mass spectrometry and chemometric analysis of licorice based on the simultaneous determination of saponins and flavonoids. J Sep Sci. 2016 Aug;39(15):2928-40. doi: 10.1002/jssc.201600246. Epub 2016 Jul 19. PubMed PMID: 27273927. 18: Zhang X, Xiong YL, Chen J, Zhou L. Synergy of licorice extract and pea protein hydrolysate for oxidative stability of soybean oil-in-water emulsions. J Agric Food Chem. 2014 Aug 13;62(32):8204-13. doi: 10.1021/jf5016126. Epub 2014 Jul 29. PubMed PMID: 25058384. 19: Li L, Liang S, Du F, Li C. Simultaneous quantification of multiple licorice flavonoids in rat plasma. J Am Soc Mass Spectrom. 2007 Apr;18(4):778-82. Epub 2007 Feb 8. PubMed PMID: 17291779. 20: Wang M, Zhang M, Tang Q, Li X. Influence of honey-roasting on the main pharmacological activities and the water-soluble active glycosides of licorice. 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