MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 592778 | Name: Metiazinic acid

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Metiazinic acid acts as an anti-inflammatory agent.

Chemical Structure

Metiazinic acid
Metiazinic acid
CAS#13993-65-2

Theoretical Analysis

MedKoo Cat#: 592778

Name: Metiazinic acid

CAS#: 13993-65-2

Chemical Formula: C15H13NO2S

Exact Mass: 271.0667

Molecular Weight: 271.33

Elemental Analysis: C, 66.40; H, 4.83; N, 5.16; O, 11.79; S, 11.82

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
Metiazinic acid
IUPAC/Chemical Name
10-Methylphenothiazine-2-acetic acid
InChi Key
LMINNBXUMGNKMM-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H13NO2S/c1-16-11-4-2-3-5-13(11)19-14-7-6-10(8-12(14)16)9-15(17)18/h2-8H,9H2,1H3,(H,17,18)
SMILES Code
O=C(O)CC(C=C1N2C)=CC=C1SC3=C2C=CC=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 271.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Klein G, Wottawa A, Altmann H, Eberl R. [Effect of metiazinic acid, ketoprofen, oxyphenbutazone, and flufenamic acid on the enzymes of DNA synthesis and repair in the in vitro experiment]. Arzneimittelforschung. 1974 Dec;24(12):1975-8. German. PubMed PMID: 4480277. 2: Machtey I. Serum uric acid levels following administration of metiazinic acid (Soripal). Clin Chim Acta. 1973 Aug 30;47(2):317-8. PubMed PMID: 4755809. 3: Akatsu T, Catanzaro Guimarães SA. Comparative effects of non-steroidal anti-inflammatory drugs, mefenamic acid, metiazinic acid and glucametacin on the inflammatory response induced by subcutaneous implantation of human dental plaque and on the mitotic activity of isoproterenol-stimulated parotid glands of rats. Cell Mol Biol. 1986;32(5):619-26. PubMed PMID: 3779763. 4: Siegmeth W. [A new molecule--international abbreviation metiazinic acid (chemical name: 10-Methyl-3-phenothiazinyl-acetic acid)--and its effect on rheumatic diseases]. Wien Med Wochenschr. 1971 Jun 5;121(23):478-84. German. PubMed PMID: 4106720. 5: Kitagawa H, Miyazu K, Tsuruta M, Sato H, Yokoshima T. Metabolic studies on metiazinic acid I. Absorption, distribution, excretion and metabolism in rats and rabbits. Jpn J Pharmacol. 1975 Feb;25(1):1-14. PubMed PMID: 1173931. 6: Baron F, Legent F, Mabit A. [Results obtained with metiazinic acid in edemas in otorhinolaryngology]. J Fr Otorhinolaryngol Audiophonol Chir Maxillofac. 1971 Jun 20;20(6):777-80. French. PubMed PMID: 4254705. 7: Jacquot F, Gras JP. [Value of metiazinic acid in the treatment of rheumatismal diseases]. Rhumatologie. 1970 Sep;22(7):265-70. French. PubMed PMID: 4252010. 8: Thomas C, Mignot R, Galoisy C. [Use of a new anti-inflammatory agent, metiazinic acid, in ophthalmology]. Bull Soc Ophtalmol Fr. 1970 Sep-Oct;70(9):921-4. French. PubMed PMID: 5526291. 9: Dalmais J, Fuvel M. [Trial of 16 091 R.P. (metiazinic acid) in general medicine]. J Med Lyon. 1971 Oct 5;52(214):1243-6. French. PubMed PMID: 4944457. 10: Ogawa K, Yokozawa S, Higashiyama R, Nihei M, Shiraishi S. [Clinical use of 16091 R.P. (Metiazinic acid) in oral surgery (author's transl)]. Nihon Koku Geka Gakkai Zasshi. 1974;20(1):71-6. Japanese. PubMed PMID: 4549806. 11: Shiokawa Y, Yamamoto M, Onoda T. [Effectiveness of 16091 R.P.(metiazinic acid) in rheumatoid arthritis]. Ryumachi. 1973 Jan;12(4):373-93. Japanese. PubMed PMID: 4576981. 12: Creff AF, Canu MF. [Utilization of the anti-inflammatory action of metiazinic acid in sport medical practice]. Therapeutique. 1970 Oct;46(8):803-4. French. PubMed PMID: 5458913. 13: Ogiuchi H, Nakamura Y, Taki H, Murase M. [Clinical use of 16091 R.P. (metiazinic acid) in oral surgery (author's transl)]. Nihon Koku Geka Gakkai Zasshi. 1973;19(1):57-62. Japanese. PubMed PMID: 4523647. 14: Hiller KO, Hodd PL, Willson RL. Antiinflammatory drugs: protection of a bacterial virus as an in vitro biological measure of free radical activity. Chem Biol Interact. 1983 Dec;47(3):293-305. PubMed PMID: 6317211. 15: Germani E, Adolphe M, Deysson MG. [Comparative study of the metiazinic acid cytotoxicity for animal and plant cells]. Ann Pharm Fr. 1975 Oct;33(10):461-6. French. PubMed PMID: 1243811. 16: Ohnishi H, Ito C, Suzuki K, Kitamura Y, Shimora M, Saito A, Itoh R. [Effects of protizinic acid on the prostaglandins system and the production of oxygen radicals]. Nihon Yakurigaku Zasshi. 1982 Jun;79(6):561-9. Japanese. PubMed PMID: 6290356. 17: Katsuki T, Nakazima K, Noutomi K, Atsumi R, Umezaki Y. [Clinical evaluation of 16091 R.P. (Metiazinic acid) by means of the double blind method with active control in oral surgery (author's transl)]. Nihon Koku Geka Gakkai Zasshi. 1974;20(5):512-6. Japanese. PubMed PMID: 4549240. 18: Ferluga J, Kaplun A, Allison AC. Protection of mice against endotoxin-induced liver damage by anti-inflammatory drugs. Agents Actions. 1979 Dec;9(5-6):566-74. PubMed PMID: 546179. 19: de Sèze S, Kahn MF, Dreyfus P, Dryll A, Solnica J, Piéra JB. [Results of controlled trial of metiazinic acid (16091 RP) in rheumatic pelvi-spondylitis, coxarthrosis and psoriatic rheumatism]. Rev Rhum Mal Osteoartic. 1969 Dec;36(12):709-13. French. PubMed PMID: 5309626. 20: Shioda S, Yamashita S, Masuda T, Soezima K, Okayama H. [Clinical evaluation of non-steroid anti-inflammatory agent, metiazinic acid (16091 R.P.) in oral regions (author's transl)]. Nihon Koku Geka Gakkai Zasshi. 1973;19(3):303-8. Japanese. PubMed PMID: 4524130.

View History

Bisulepin

Bisulepin