Mitoquinol-d15 | CAS#unknown | Mitoquinol internal standard

MedKoo Cat#: 465219 | Name: Mitoquinol-d15

Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Mitoquinol-d15 is intended for use as an internal standard for the quantification of mitoquinol by GC- or LC-MS. Mitoquinol is a mitochondria-targeted antioxidant and reduced form of mitoquinone. It reduces hydrogen peroxide production in succinate-fueled isolated bovine aortic endothelial mitochondria.

Chemical Structure

Mitoquinol-d15

CAS#unknown

Theoretical Analysis

MedKoo Cat#: 465219

Name: Mitoquinol-d15

CAS#: unknown

Chemical Formula: C38H34D15O7PS

Exact Mass: 695.3878

Molecular Weight: 695.93

Elemental Analysis: C, 65.58; H, 9.27; O, 16.09; P, 4.45; S, 4.61

Price and Availability

Size	Price	Availability	Quantity
1mg	USD 350.00	2 Weeks
5mg	USD 985.00	2 Weeks

Bulk Inquiry

Buy Now

Add to Cart

Related CAS #

No Data

Synonym

Mitoquinol-d15; Mitoquinol d15;

IUPAC/Chemical Name

(10-(2,5-dihydroxy-3,4-dimethoxy-6-methylphenyl)decyl)tris(phenyl-d5)phosphonium methanesulfonate

InChi Key

WPMXVYGZUOSRAN-DBFLYWEVSA-N

InChi Code

InChI=1S/C37H45O4P.CH4O3S/c1-29-33(35(39)37(41-3)36(40-2)34(29)38)27-19-8-6-4-5-7-9-20-28-42(30-21-13-10-14-22-30,31-23-15-11-16-24-31)32-25-17-12-18-26-32;1-5(2,3)4/h10-18,21-26H,4-9,19-20,27-28H2,1-3H3,(H-,38,39);1H3,(H,2,3,4)/i10D,11D,12D,13D,14D,15D,16D,17D,18D,21D,22D,23D,24D,25D,26D;

SMILES Code

O=S(C)([O-])=O.OC1=C(C(C)=C(C(OC)=C1OC)O)CCCCCCCCCC[P+](C2=C(C([2H])=C(C([2H])=C2[2H])[2H])[2H])(C3=C(C([2H])=C(C([2H])=C3[2H])[2H])[2H])C4=C(C([2H])=C(C([2H])=C4[2H])[2H])[2H]

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 695.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sulaimon LA, Adisa RA, Samuel TA, Joel IY, Ayankojo AG, Abdulkareem FB, Olaniyi TO. Molecular mechanism of mitoquinol mesylate in mitigating the progression of hepatocellular carcinoma-in silico and in vivo studies. J Cell Biochem. 2021 Apr 28. doi: 10.1002/jcb.29937. Epub ahead of print. PMID: 33909925. 2: Rudolph TE, Mayorga EJ, Roths M, Rhoads RP, Baumgard LH, Selsby JT. The effect of Mitoquinol (MitoQ) on heat stressed skeletal muscle from pigs, and a potential confounding effect of biological sex. J Therm Biol. 2021 Apr;97:102900. doi: 10.1016/j.jtherbio.2021.102900. Epub 2021 Mar 6. PMID: 33863453. 3: Kageyama M, Ito J, Shirasuna K, Kuwayama T, Iwata H. Mitochondrial reactive oxygen species regulate mitochondrial biogenesis in porcine embryos. J Reprod Dev. 2021 Apr 21;67(2):141-147. doi: 10.1262/jrd.2020-111. Epub 2021 Feb 20. PMID: 33612552; PMCID: PMC8075724. 4: Cho SJ, Hong KS, Schenck E, Lee S, Harris R, Yang J, Choi AMK, Stout-Delgado H. Decreased IDO1-dependent tryptophan metabolism in aged lung during influenza. Eur Respir J. 2021 May 13;57(5):2000443. doi: 10.1183/13993003.00443-2020. PMID: 33243840; PMCID: PMC8147522. 5: Mansell E, Sigurdsson V, Deltcheva E, Brown J, James C, Miharada K, Soneji S, Larsson J, Enver T. Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function. Cell Stem Cell. 2021 Feb 4;28(2):241-256.e6. doi: 10.1016/j.stem.2020.09.018. Epub 2020 Oct 20. PMID: 33086034. 6: Elswood J, Pearson SJ, Payne HR, Barhoumi R, Rijnkels M, W Porter W. Autophagy regulates functional differentiation of mammary epithelial cells. Autophagy. 2021 Feb;17(2):420-438. doi: 10.1080/15548627.2020.1720427. Epub 2020 Feb 5. PMID: 31983267; PMCID: PMC8007166. 7: Ibrahim AA, Karam HM, Shaaban EA, Safar MM, El-Yamany MF. MitoQ ameliorates testicular damage induced by gamma irradiation in rats: Modulation of mitochondrial apoptosis and steroidogenesis. Life Sci. 2019 Sep 1;232:116655. doi: 10.1016/j.lfs.2019.116655. Epub 2019 Jul 13. PMID: 31306659. 8: Fink BD, Herlein JA, Yorek MA, Fenner AM, Kerns RJ, Sivitz WI. Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells. J Pharmacol Exp Ther. 2012 Sep;342(3):709-19. doi: 10.1124/jpet.112.195586. Epub 2012 Jun 1. PMID: 22661629; PMCID: PMC3422527. 9: Nierobisz LS, McFarland DC, Mozdziak PE. MitoQ10 induces adipogenesis and oxidative metabolism in myotube cultures. Comp Biochem Physiol B Biochem Mol Biol. 2011 Feb;158(2):125-31. doi: 10.1016/j.cbpb.2010.10.003. Epub 2010 Oct 18. PMID: 20965270. 10: Mustapha NM, Tarr JM, Kohner EM, Chibber R. NADPH Oxidase versus Mitochondria-Derived ROS in Glucose-Induced Apoptosis of Pericytes in Early Diabetic Retinopathy. J Ophthalmol. 2010;2010:746978. doi: 10.1155/2010/746978. Epub 2010 Jun 28. PMID: 20652059; PMCID: PMC2905948. 11: Hobbs CE, Murphy MP, Smith RA, Oorschot DE. Neonatal rat hypoxia-ischemia: Effect of the anti-oxidant mitoquinol, and S-PBN. Pediatr Int. 2008 Aug;50(4):481-8. doi: 10.1111/j.1442-200X.2008.02705.x. PMID: 18937752. 12: Li Y, Fawcett JP, Zhang H, Tucker IG. Transport and metabolism of MitoQ10, a mitochondria-targeted antioxidant, in Caco-2 cell monolayers. J Pharm Pharmacol. 2007 Apr;59(4):503-11. doi: 10.1211/jpp.59.4.0004. PMID: 17430633. 13: O'Malley Y, Fink BD, Ross NC, Prisinzano TE, Sivitz WI. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. J Biol Chem. 2006 Dec 29;281(52):39766-75. doi: 10.1074/jbc.M608268200. Epub 2006 Oct 23. PMID: 17060316. 14: Kalivendi SV, Konorev EA, Cunningham S, Vanamala SK, Kaji EH, Joseph J, Kalyanaraman B. Doxorubicin activates nuclear factor of activated T-lymphocytes and Fas ligand transcription: role of mitochondrial reactive oxygen species and calcium. Biochem J. 2005 Jul 15;389(Pt 2):527-39. doi: 10.1042/BJ20050285. PMID: 15799720; PMCID: PMC1175131. 15: Bedogni B, Pani G, Colavitti R, Riccio A, Borrello S, Murphy M, Smith R, Eboli ML, Galeotti T. Redox regulation of cAMP-responsive element-binding protein and induction of manganous superoxide dismutase in nerve growth factor- dependent cell survival. J Biol Chem. 2003 May 9;278(19):16510-9. doi: 10.1074/jbc.M301089200. Epub 2003 Feb 27. PMID: 12609977. 16: Kelso GF, Porteous CM, Hughes G, Ledgerwood EC, Gane AM, Smith RA, Murphy MP. Prevention of mitochondrial oxidative damage using targeted antioxidants. Ann N Y Acad Sci. 2002 Apr;959:263-74. doi: 10.1111/j.1749-6632.2002.tb02098.x. PMID: 11976201. 17: Kelso GF, Porteous CM, Coulter CV, Hughes G, Porteous WK, Ledgerwood EC, Smith RA, Murphy MP. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem. 2001 Feb 16;276(7):4588-96. doi: 10.1074/jbc.M009093200. Epub 2000 Nov 22. PMID: 11092892.

View History

Bis-PEG1-NHS ester