Justicidin D | CAS#27041-98-1 | antiviral lignan

MedKoo Cat#: 598851 | Name: Justicidin D

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Justicidin D is an antiviral lignan.

Chemical Structure

Justicidin D

CAS#27041-98-1

Theoretical Analysis

MedKoo Cat#: 598851

Name: Justicidin D

CAS#: 27041-98-1

Chemical Formula: C21H14O7

Exact Mass: 378.0740

Molecular Weight: 378.33

Elemental Analysis: C, 66.67; H, 3.73; O, 29.60

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Justicidin D; Lignan J1; Neojusticin; Neojusticin A;

IUPAC/Chemical Name

9-(benzo[d][1,3]dioxol-5-yl)-5-methoxyfuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

InChi Key

WOELDRZIQLRDQB-UHFFFAOYSA-N

InChi Code

InChI=1S/C21H14O7/c1-23-20-12-6-17-16(27-9-28-17)5-11(12)18(13-7-24-21(22)19(13)20)10-2-3-14-15(4-10)26-8-25-14/h2-6H,7-9H2,1H3

SMILES Code

O=C1OCC2=C1C(OC)=C3C=C4OCOC4=CC3=C2C5=CC(OCO6)=C6C=C5

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 378.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Hemmati S, Schneider B, Schmidt TJ, Federolf K, Alfermann AW, Fuss E. Justicidin B 7-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum perenne Himmelszelt involved in the biosynthesis of diphyllin. Phytochemistry. 2007 Nov-Dec;68(22-24):2736-43. Epub 2007 Nov 13. PubMed PMID: 17997463. 2: Hemmati S, Schmidt TJ, Fuss E. (+)-Pinoresinol/(-)-lariciresinol reductase from Linum perenne Himmelszelt involved in the biosynthesis of justicidin B. FEBS Lett. 2007 Feb 20;581(4):603-10. Epub 2007 Jan 18. PubMed PMID: 17257599. 3: Asano J, Chiba K, Tada M, Yoshii T. Antiviral activity of lignans and their glycosides from Justicia procumbens. Phytochemistry. 1996 Jun;42(3):713-7. PubMed PMID: 8768323. 4: Yang M, Wu J, Xu X, Jin Y, Guo Y, Chen J. A new lignan from the Jian-er syrup and its content determination by RP-HPLC. J Pharm Biomed Anal. 2006 May 3;41(2):662-6. Epub 2006 Jan 18. PubMed PMID: 16413731. 5: Rajasekhar D, Subbaraju GV, Pillai KR. Justicia lignans VI--prostalidin D, a new arylnaphthalide lignan from Justicia diffusa var. prostrata C.B. Clarke. J Asian Nat Prod Res. 2000;2(4):289-300. PubMed PMID: 11249611. 6: Padwa A, Cochran JE, Kappe CO. Tandem Pummerer-Diels-Alder Reaction Sequence. A Novel Cascade Process for the Preparation of 1-Arylnaphthalene Lignans. J Org Chem. 1996 May 31;61(11):3706-3714. PubMed PMID: 11667219. 7: Schmidt TJ, Vössing S, Klaes M, Grimme S. An aryldihydronaphthalene lignan with a novel type of ring system and further new lignans from linum perenne L. Planta Med. 2007 Dec;73(15):1574-80. Epub 2007 Dec 7. PubMed PMID: 18067061. 8: Weng JR, Ko HH, Yeh TL, Lin HC, Lin CN. Two new arylnaphthalide lignans and antiplatelet constituents from Justicia procumbens. Arch Pharm (Weinheim). 2004 Apr;337(4):207-12. PubMed PMID: 15065080. 9: Day SH, Lin YC, Tsai ML, Tsao LT, Ko HH, Chung MI, Lee JC, Wang JP, Won SJ, Lin CN. Potent cytotoxic lignans from Justicia procumbens and their effects on nitric oxide and tumor necrosis factor-alpha production in mouse macrophages. J Nat Prod. 2002 Mar;65(3):379-81. PubMed PMID: 11908984. 10: Mohagheghzadeh A, Schmidt TJ, Alfermann AW. Arylnaphthalene lignans from in vitro cultures of Linum austriacum. J Nat Prod. 2002 Jan;65(1):69-71. PubMed PMID: 11809070. 11: Jiang J, Dong H, Wang T, Zhao R, Mu Y, Geng Y, Zheng Z, Wang X. A Strategy for Preparative Separation of 10 Lignans from Justicia procumbens L. by High-Speed Counter-Current Chromatography. Molecules. 2017 Nov 23;22(12). pii: E2024. doi: 10.3390/molecules22122024. PubMed PMID: 29168751.