FAPI-Cy7-Cl is a near-infrared fluorescent probe with prolonged tumor retention (>72 h) and high target-to-background ratios (up to 4.5) based on the conjugation of pan-cancer targeted fibroblast activation protein inhibitor(FAPI) and the “tumor-seeking” Cyanine 7 bearing a meso-chloride and a cyclohexenyl skeleton (Cy7-Cl). FAPI-Cy7-Cl exhibited superior imaging performance in both estrogen receptor α positive breast cancer (MCF-7) and triple-negative breast cancer (TNBC) (MDA-MB-231) subtypes in mouse models. Notably, in the MDA-MB-231 tumor-bearing model, the tumor-to-liver ratio (T/L) of FAPI-Cy7-Cl increased rapidly after 2 h postinjection, reaching nearly 4.5 at 48 h, making it an optimal imaging probe for guiding TNBC surgery resection.
MedKoo Cat#: 128343
Name: FAPI-Cy7-Cl
CAS#: N/A
Chemical Formula: C76H94Cl2F2N12O7
Exact Mass: 1394.6714
Molecular Weight: 1396.56
Elemental Analysis: C, 65.36; H, 6.78; Cl, 5.08; F, 2.72; N, 12.04; O, 8.02
The following data is based on the product molecular weight 1,396.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
