MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 598845 | Name: Pyrithioxin HCl
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pyrithioxin HCl is a neurotropic agent with no vitamin B6 activity.

Chemical Structure

Pyrithioxin HCl
Pyrithioxin HCl
CAS#10049-83-9

Theoretical Analysis

MedKoo Cat#: 598845

Name: Pyrithioxin HCl

CAS#: 10049-83-9

Chemical Formula: C16H22Cl2N2O4S2

Exact Mass:

Molecular Weight: 441.38

Elemental Analysis: C, 43.54; H, 5.02; Cl, 16.06; N, 6.35; O, 14.50; S, 14.53

Price and Availability

Size Price Availability Quantity
25g USD 230.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
1098-97-1
Synonym
Pyrithioxine hydrochloride; Pyrithioxine HCl; Life; NSC 526973; NSC-526973; NSC526973; Pyriditol; Bonifen; Dinerfene;
IUPAC/Chemical Name
5,5'-(disulfanediylbis(methylene))bis(4-(hydroxymethyl)-2-methylpyridin-3-ol) dihydrochloride
InChi Key
HRZWYHGGJOWGRI-UHFFFAOYSA-N
InChi Code
InChI=1S/C16H20N2O4S2.2ClH/c1-9-15(21)13(5-19)11(3-17-9)7-23-24-8-12-4-18-10(2)16(22)14(12)6-20;;/h3-4,19-22H,5-8H2,1-2H3;2*1H
SMILES Code
OCC1=C(CSSCC2=C(CO)C(O)=C(C)N=C2)C=NC(C)=C1O.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO and water
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Pyrithioxin HCl is a salt.
In vitro activity:
To be determined
In vivo activity:
Behavioral effects were assessed in both young and old rats with pyrithioxin administration, which has been reported to elevate acetylcholine levels in several brain regions in old rats. This study found that in both young and old rats, pyrithioxin had no effect on locomotor activity or swim speed, but enhanced one trial passive avoidance retention. Reference: J Psychopharmacol. 1987 Jan;1(4):237-43. https://pubmed.ncbi.nlm.nih.gov/22159136/
Solvent mg/mL mM
Solubility
DMSO 88.0 199.37
Water 88.0 199.37
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 441.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Martin KJ, Vyas S. Increase in acetylcholine concentrations in the brain of 'old' rats following treatment with pyrithioxin (Encephabol). Br J Pharmacol. 1987 Mar;90(3):561-5. doi: 10.1111/j.1476-5381.1987.tb11206.x. PMID: 3567461; PMCID: PMC1917181. 2. Marston HM, Martin KJ, Robbins TW. Effects of the chronic administration of pyrithioxin on behaviour and cholinergic function in young and aged rats. J Psychopharmacol. 1987 Jan;1(4):237-43. doi: 10.1177/026988118700100404. PMID: 22159136.
In vitro protocol:
To be determined
In vivo protocol:
1. Martin KJ, Vyas S. Increase in acetylcholine concentrations in the brain of 'old' rats following treatment with pyrithioxin (Encephabol). Br J Pharmacol. 1987 Mar;90(3):561-5. doi: 10.1111/j.1476-5381.1987.tb11206.x. PMID: 3567461; PMCID: PMC1917181. 2. Marston HM, Martin KJ, Robbins TW. Effects of the chronic administration of pyrithioxin on behaviour and cholinergic function in young and aged rats. J Psychopharmacol. 1987 Jan;1(4):237-43. doi: 10.1177/026988118700100404. PMID: 22159136.
1: Wälti U, Kuenzler M, Schild J, Vassella F, Pavlincova E, Bircher J, Herschkowitz N. Pyritinol hydrochloride and cognitive functions: influence on children in slow learner classes. Pediatr Res. 1975 Sep;9(9):717-21. PubMed PMID: 1105370. 2: Hagenah R. [Neuropharmacologic and neurotoxic studies on the Renshaw mechanism]. Fortschr Med. 1979 Nov 1;97(41):1840-4. German. PubMed PMID: 535853. 3: Hoyer S, Oesterreich K, Stoll KD. Effect of pyritinol-GCl on blood flow and oxidative metabolism of the brain in patients with dementia. Arzneimittelforschung. 1977;27(3):671-4. PubMed PMID: 577444.