Synonym
Vamidothion; Kilval; Trucidor; RP-9895; RP 9895; RP9895; RP 10465; RP-10465; RP10465;
IUPAC/Chemical Name
O,O-dimethyl S-(2-((1-(methylamino)-1-oxopropan-2-yl)thio)ethyl) phosphorothioate
InChi Key
LESVOLZBIFDZGS-UHFFFAOYSA-N
InChi Code
InChI=1S/C8H18NO4PS2/c1-7(8(10)9-2)15-5-6-16-14(11,12-3)13-4/h7H,5-6H2,1-4H3,(H,9,10)
SMILES Code
CC(SCCSP(OC)(OC)=O)C(NC)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
287.32
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Yamagishi Y, Nagasawa S, Iwase H, Ogra Y. Evaluation of organophosphorus pesticide tyrosine adducts for postmortem change by human serum albumin with liquid chromatography quadrupole Orbitrap mass spectrometry. Toxicol Sci. 2024 Apr 29;199(1):40-48. doi: 10.1093/toxsci/kfae023. PMID: 38366941.
2: Gru Y, Colin R, Le Cloirec P. Investigation of matrix effects for some pesticides in waters by on-line solid-phase extraction-liquid chromatography coupled with triple quadrupole linear ion-trap mass spectrometry and the use of postcolumn introduction. J AOAC Int. 2010 May-Jun;93(3):1020-31. PMID: 20629409.
3: Hayama T, Yoshida H, Todoroki K, Nohta H, Yamaguchi M. Determination of polar organophosphorus pesticides in water samples by hydrophilic interaction liquid chromatography with tandem mass spectrometry. Rapid Commun Mass Spectrom. 2008 Jul;22(14):2203-10. doi: 10.1002/rcm.3573. PMID: 18543372.
4: Mol HG, van Dam RC, Steijger OM. Determination of polar organophosphorus pesticides in vegetables and fruits using liquid chromatography with tandem mass spectrometry: selection of extraction solvent. J Chromatogr A. 2003 Oct 10;1015(1-2):119-27. doi: 10.1016/s0021-9673(03)01209-3. PMID: 14570325.
5: Abe T, Yoshiike N, Yamaguchi H. [Utilization of school lunch dietary data to estimate theoretical maximum daily intake (TMDI) of selected pesticide residues]. Nihon Eiseigaku Zasshi. 2003 Sep;58(3):376-84. Japanese. doi: 10.1265/jjh.58.376. PMID: 14533567.
6: Ingelse BA, van Dam RC, Vreeken RJ, Mol HG, Steijger OM. Determination of polar organophosphorus pesticides in aqueous samples by direct injection using liquid chromatography-tandem mass spectrometry. J Chromatogr A. 2001 May 18;918(1):67-78. doi: 10.1016/s0021-9673(01)00660-4. PMID: 11403457.
7: Cabrera HA, Menezes HC, Oliveira JV, Batista RF. Evaluation of residual levels of benomyl, methyl parathion, diuron, and vamidothion in pineapple pulp and bagasse (Smooth cayenne). J Agric Food Chem. 2000 Nov;48(11):5750-3. doi: 10.1021/jf9911444. PMID: 11087549.
8: Tsumura Y, Matsuki H, Tonogai Y, Nakamura Y, Kato S, Ito Y. Simultaneous Determination of Vamidothion and Its Oxidation Metabolites in Potatoes and Apples by Gas Chromatography. J Food Prot. 1993 May;56(5):437-440. doi: 10.4315/0362-028X-56.5.437. PMID: 31084145.
9: Drevenkar V, Radić Z, Vasilić Z, Reiner E. Dialkylphosphorus metabolites in the urine and activities of esterases in the serum as biochemical indices for human absorption of organophosphorus pesticides. Arch Environ Contam Toxicol. 1991 Apr;20(3):417-22. doi: 10.1007/BF01064413. PMID: 1650168.
10: Tezuka H, Ando N, Suzuki R, Terahata M, Moriya M, Shirasu Y. Sister- chromatid exchanges and chromosomal aberrations in cultured Chinese hamster cells treated with pesticides positive in microbial reversion assays. Mutat Res. 1980 Jun;78(2):177-91. doi: 10.1016/0165-1218(80)90097-x. PMID: 7393245.
11: Shirasu Y, Moriya M, Kato K, Furuhashi A, Kada T. Mutagenicity screening of pesticides in the microbial system. Mutat Res. 1976 Jan;40(1):19-30. doi: 10.1016/0165-1218(76)90018-5. PMID: 814455.
12: Dubosq F, Dedde M. Dosage du vamidothion technique ou formulé par chromatographie en phase gazeuse [Determination of vamidothion technical or formulated by gas chromatography]. J Chromatogr. 1972 Sep 20;71(3):557-61. French. doi: 10.1016/s0021-9673(01)91914-4. PMID: 5074288.
13: Pak LB. K voprosu o toksichnosti vamidotiona dlia teplokrovnykh zhivotnykh [The toxicity of Vamidothion in relation to warm-blooded animals]. Gig Tr Prof Zabol. 1970 Feb;14(2):58-9. Russian. PMID: 5443457.
