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MedKoo Cat#: 598808 | Name: Libramycin A

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Libramycin A is a fat-soluble, weakly acidic substance isolated from Streptomyces.

Chemical Structure

Libramycin A
Libramycin A
CAS#51746-00-0

Theoretical Analysis

MedKoo Cat#: 598808

Name: Libramycin A

CAS#: 51746-00-0

Chemical Formula: C11H20N2O3

Exact Mass: 228.1474

Molecular Weight: 228.29

Elemental Analysis: C, 57.87; H, 8.83; N, 12.27; O, 21.02

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Libramycin A;
IUPAC/Chemical Name
2-methyl-6-((4S,5R)-5-methyl-2-oxoimidazolidin-4-yl)hexanoic acid
InChi Key
DSLSWBIYQALLJM-ASODMVGOSA-N
InChi Code
InChI=1S/C11H20N2O3/c1-7(10(14)15)5-3-4-6-9-8(2)12-11(16)13-9/h7-9H,3-6H2,1-2H3,(H,14,15)(H2,12,13,16)/t7?,8-,9+/m1/s1
SMILES Code
C[C@@H]1[C@H](CCCCC(C(O)=O)C)NC(N1)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 228.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Metsemakers WJ, Emanuel N, Cohen O, Reichart M, Potapova I, Schmid T, Segal D, Riool M, Kwakman PH, de Boer L, de Breij A, Nibbering PH, Richards RG, Zaat SA, Moriarty TF. A doxycycline-loaded polymer-lipid encapsulation matrix coating for the prevention of implant-related osteomyelitis due to doxycycline-resistant methicillin-resistant Staphylococcus aureus. J Control Release. 2015 Jul 10;209:47-56. doi: 10.1016/j.jconrel.2015.04.022. Epub 2015 Apr 21. PubMed PMID: 25910578. 2: Kroon AM, Taanman JW. Clonal expansion of T cells in abdominal aortic aneurysm: a role for doxycycline as drug of choice? Int J Mol Sci. 2015 May 18;16(5):11178-95. doi: 10.3390/ijms160511178. Review. PubMed PMID: 25993290; PubMed Central PMCID: PMC4463695. 3: Zhang GB, Feng YH, Wang PQ, Song JH, Wang P, Wang SA. A study on the protective role of doxycycline upon dopaminergic neuron of LPS-PD rat model rat. Eur Rev Med Pharmacol Sci. 2015 Sep;19(18):3468-74. PubMed PMID: 26439044. 4: Fredeking TM, Zavala-Castro JE, González-Martínez P, Moguel-Rodríguez W, Sanchez EC, Foster MJ, Diaz-Quijano FA. Dengue Patients Treated with Doxycycline Showed Lower Mortality Associated to a Reduction in IL-6 and TNF Levels. Recent Pat Antiinfect Drug Discov. 2015;10(1):51-8. PubMed PMID: 25858261. 5: Pereira JA, Marques MJ, Santo Neto H. Co-administration of deflazacort and doxycycline: a potential pharmacotherapy for Duchenne muscular dystrophy. Clin Exp Pharmacol Physiol. 2015 Jul;42(7):788-94. doi: 10.1111/1440-1681.12417. PubMed PMID: 25959722. 6: Kim SE, Kim S, Jeong M, Lee Y, Ahn JT, Park YW, Ahn JS, Lee E, Ryu DY, Seo K. Experimental determination of a subantimicrobial dosage of doxycycline hyclate for treatment of periodontitis in Beagles. Am J Vet Res. 2013 Jan;74(1):130-5. doi: 10.2460/ajvr.74.1.130. PubMed PMID: 23270357. 7: Shiels WE 2nd, Mayerson JL. Percutaneous doxycycline treatment of aneurysmal bone cysts with low recurrence rate: a preliminary report. Clin Orthop Relat Res. 2013 Aug;471(8):2675-83. doi: 10.1007/s11999-013-3043-2. Epub 2013 May 14. PubMed PMID: 23670673; PubMed Central PMCID: PMC3705068. 8: Moore A, Ling M, Bucko A, Manna V, Rueda MJ. Efficacy and Safety of Subantimicrobial Dose, Modified-Release Doxycycline 40 mg Versus Doxycycline 100 mg Versus Placebo for the treatment of Inflammatory Lesions in Moderate and Severe Acne: A Randomized, Double-Blinded, Controlled Study. J Drugs Dermatol. 2015 Jun;14(6):581-6. PubMed PMID: 26091383. 9: Ïlem-Özdemir D, Asikoglu M, Ozkilic H, Yilmaz F, Hosgor-Limoncu M, Ayhan S. (99m) Tc-Doxycycline hyclate: a new radiolabeled antibiotic for bacterial infection imaging. J Labelled Comp Radiopharm. 2014 Jan;57(1):36-41. doi: 10.1002/jlcr.3135. Epub 2013 Nov 21. PubMed PMID: 24259028. 10: Menozzi A, Bertini S, Turin L, Serventi P, Kramer L, Bazzocchi C. Doxycycline levels and anti-Wolbachia antibodies in sera from dogs experimentally infected with Dirofilaria immitis and treated with a combination of ivermectin/doxycycline. Vet Parasitol. 2015 Apr 30;209(3-4):281-4. doi: 10.1016/j.vetpar.2015.02.023. Epub 2015 Feb 28. PubMed PMID: 25769472. 11: Bupp JE, Tanga MJ. Synthesis of a doxycycline-[(13) CD3 ] standard. J Labelled Comp Radiopharm. 2016 Jun 15;59(7):291-3. doi: 10.1002/jlcr.3397. Epub 2016 Apr 6. PubMed PMID: 27061598; PubMed Central PMCID: PMC4892950. 12: Weinstein M, Laxer R, Debosz J, Somers G. Doxycycline-induced cutaneous inflammation with systemic symptoms in a patient with acne vulgaris. J Cutan Med Surg. 2013 Jul-Aug;17(4):283-6. PubMed PMID: 23815962. 13: Leyden JJ, Bruce S, Lee CS, Ling M, Sheth PB, Stewart DM, Werschler WP, Gilbert RD, Kircik L. A randomized, phase 2, dose-ranging study in the treatment of moderate to severe inflammatory facial acne vulgaris with doxycycline calcium. J Drugs Dermatol. 2013 Jun 1;12(6):658-63. PubMed PMID: 23839182. 14: Dodd BR, Spence RA. Doxycycline inhibition of abdominal aortic aneurysm growth: a systematic review of the literature. Curr Vasc Pharmacol. 2011 Jul 1;9(4):471-8. Review. PubMed PMID: 21595625. 15: Tashkhourian J, Absalan G, Jafari M, Zare S. A rapid and sensitive assay for determination of doxycycline using thioglycolic acid-capped cadmium telluride quantum dots. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 5;152:119-25. doi: 10.1016/j.saa.2015.07.063. Epub 2015 Jul 13. PubMed PMID: 26204505. 16: Li S, Li J, Lin Q, Wei X. A molecularly imprinted sensor based on an electrochemiluminescent membrane for ultratrace doxycycline determination. Analyst. 2015 Jul 7;140(13):4702-7. doi: 10.1039/c5an00416k. PubMed PMID: 25962832. 17: Frye LJ, Chong E, Winikoff B; NCT01799252 Trial Investigators. What happens when we routinely give doxycycline to medical abortion patients? Contraception. 2015 Jan;91(1):19-24. doi: 10.1016/j.contraception.2014.09.001. Epub 2014 Sep 15. PubMed PMID: 25444253. 18: Kogawa AC, Zoppi A, Quevedo MA, Nunes Salgado HR, Longhi MR. Increasing doxycycline hyclate photostability by complexation with β-cyclodextrin. AAPS PharmSciTech. 2014 Oct;15(5):1209-17. doi: 10.1208/s12249-014-0150-7. Epub 2014 Jun 3. PubMed PMID: 24889734; PubMed Central PMCID: PMC4179669. 19: Conejos-Sánchez I, Cardoso I, Oteo-Vives M, Romero-Sanz E, Paul A, Sauri AR, Morcillo MA, Saraiva MJ, Vicent MJ. Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease. J Control Release. 2015 Jan 28;198:80-90. doi: 10.1016/j.jconrel.2014.12.003. Epub 2014 Dec 4. PubMed PMID: 25481444. 20: Maher MC, Schnabel LV, Cross JA, Papich MG, Divers TJ, Fortier LA. Plasma and synovial fluid concentration of doxycycline following low-dose, low-frequency administration, and resultant inhibition of matrix metalloproteinase-13 from interleukin-stimulated equine synoviocytes. Equine Vet J. 2014 Mar;46(2):198-202. doi: 10.1111/evj.12139. Epub 2013 Dec 5. PubMed PMID: 23855565.

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