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MedKoo Cat#: 591435 | Name: AH 22921

Description:

WARNING: This product is for research use only, not for human or veterinary use.

AH 22921 is a thromboxane A2 antagonist.

Chemical Structure

AH 22921
AH 22921
CAS#123122-56-5

Theoretical Analysis

MedKoo Cat#: 591435

Name: AH 22921

CAS#: 123122-56-5

Chemical Formula: C29H35NO5

Exact Mass: 477.2515

Molecular Weight: 477.60

Elemental Analysis: C, 72.93; H, 7.39; N, 2.93; O, 16.75

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
AH 22921; AH22921; AH-22921
IUPAC/Chemical Name
5-Heptenoic acid, 7-(5-((1,1'-biphenyl)-4-ylmethoxy)-2-(4-morpholinyl)-3-oxocyclopentyl)-, (1alpha(Z),2beta,5alpha)-
InChi Key
UWQXOMOFJWMVPM-BJHZJVKSSA-N
InChi Code
InChI=1S/C29H35NO5/c31-26-20-27(35-21-22-12-14-24(15-13-22)23-8-4-3-5-9-23)25(10-6-1-2-7-11-28(32)33)29(26)30-16-18-34-19-17-30/h1,3-6,8-9,12-15,25,27,29H,2,7,10-11,16-21H2,(H,32,33)/b6-1-/t25-,27-,29+/m0/s1
SMILES Code
O=C(O)CCC/C=C\C[C@@H]1[C@@H](N2CCOCC2)C(C[C@@H]1OCC3=CC=C(C4=CC=CC=C4)C=C3)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 477.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sharif NA, Xu SX. Pharmacological characterization and identification of EP3 prostanoid receptor binding sites in hamster uterus homogenates. J Pharm Pharmacol. 2004 Feb;56(2):197-203. PubMed PMID: 15005878. 2: Crider JY, Griffin BW, Sharif NA. Endogenous EP4 prostaglandin receptors coupled positively to adenylyl cyclase in Chinese hamster ovary cells: pharmacological characterization. Prostaglandins Leukot Essent Fatty Acids. 2000 Jan;62(1):21-6. PubMed PMID: 10765975. 3: Coleman RA, Mallett A, Sheldrick RL. EP4-receptors and cyclic AMP in pig venous smooth muscle: evidence with agonists and the EP4-antagonist, AH22921. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:241-6. PubMed PMID: 7732844. 4: Boura AL, Gude NM, King RG, Mak KK, Walters WA. Characterization of thromboxane A2 receptors in the human fetal placental vessels and umbilical vein. Clin Exp Pharmacol Physiol. 1986 Jan;13(1):83-6. PubMed PMID: 3011331.