QO-40 | CAS#1259536-70-3 | channel activator

MedKoo Cat#: 563518 | Name: QO-40

Description:

WARNING: This product is for research use only, not for human or veterinary use.

QO-40 is an activator of KCNQ2/3 potassium channels.

Chemical Structure

QO-40

CAS#1259536-70-3

Theoretical Analysis

MedKoo Cat#: 563518

Name: QO-40

CAS#: 1259536-70-3

Chemical Formula: C18H11ClF3N3O

Exact Mass: 377.0543

Molecular Weight: 377.75

Elemental Analysis: C, 57.23; H, 2.94; Cl, 9.38; F, 15.09; N, 11.12; O, 4.24

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

QO-40; QO 40; QO40;

IUPAC/Chemical Name

5-(Chloromethyl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

InChi Key

RDXPGBXYEGTHBJ-UHFFFAOYSA-N

InChi Code

InChI=1S/C18H11ClF3N3O/c19-9-11-8-14(26)25-17(23-11)15(16(24-25)18(20,21)22)13-7-3-5-10-4-1-2-6-12(10)13/h1-8,23H,9H2

SMILES Code

5-(Chloromethyl)-3-(naphthalen-1-yl)-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 377.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Jia C, Qi J, Zhang F, Mi Y, Zhang X, Chen X, Liu L, Du X, Zhang H. Activation of KCNQ2/3 potassium channels by novel pyrazolo[1,5-a]pyrimidin-7(4H)-one derivatives. Pharmacology. 2011;87(5-6):297-310. doi: 10.1159/000327384. Epub 2011 May 17. PubMed PMID: 21577044.