Org 30850 | CAS#gonadorelin antagonist. | gonadorelin antagonist

MedKoo Cat#: 598801 | Name: Org 30850

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Org 30850 is a gonadorelin antagonist.

Chemical Structure

Org 30850

CAS#136208-71-4

Theoretical Analysis

MedKoo Cat#: 598801

Name: Org 30850

CAS#: 136208-71-4

Chemical Formula: C69H91Cl2N15O13S

Exact Mass: 1439.6019

Molecular Weight: 1441.53

Elemental Analysis: C, 57.49; H, 6.36; Cl, 4.92; N, 14.58; O, 14.43; S, 2.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Org 30850; Org-30850; Org30850; Org 30850 ant;

IUPAC/Chemical Name

(S)-1-(((R)-2-((R)-2-((R)-2-acetamido-3-(4-chlorophenyl)propanamido)-3-(4-chlorophenyl)propanamido)-3-(benzo[b]thiophen-3-yl)propanoyl)-L-seryl-L-tyrosyl-D-lysyl-L-leucyl-L-arginyl)-N-((R)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide

InChi Key

ONHXPWXXSUUCDR-SLMFISIISA-N

InChi Code

InChI=1S/C69H91Cl2N15O13S/c1-38(2)31-51(61(92)80-50(13-9-29-76-69(74)75)68(99)86-30-10-14-57(86)67(98)77-39(3)59(73)90)81-60(91)49(12-7-8-28-72)79-63(94)53(34-43-20-26-47(89)27-21-43)83-66(97)56(36-87)85-65(96)55(35-44-37-100-58-15-6-5-11-48(44)58)84-64(95)54(33-42-18-24-46(71)25-19-42)82-62(93)52(78-40(4)88)32-41-16-22-45(70)23-17-41/h5-6,11,15-27,37-39,49-57,87,89H,7-10,12-14,28-36,72H2,1-4H3,(H2,73,90)(H,77,98)(H,78,88)(H,79,94)(H,80,92)(H,81,91)(H,82,93)(H,83,97)(H,84,95)(H,85,96)(H4,74,75,76)/t39-,49-,50+,51+,52-,53+,54-,55-,56+,57+/m1/s1

SMILES Code

C[C@H](C(N)=O)NC([C@H]1N(C([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H](CCCCN)NC([C@H](CC2=CC=C(O)C=C2)NC([C@H](CO)NC([C@@H](CC3=CSC4=CC=CC=C43)NC([C@@H](CC5=CC=C(Cl)C=C5)NC([C@@H](CC6=CC=C(Cl)C=C6)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,441.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Deckers GH, de Graaf JH, Kloosterboer HJ, Loozen HJ. Properties of a potent LHRH antagonist (Org 30850) in female and male rats. J Steroid Biochem Mol Biol. 1992 Aug;42(7):705-12. PubMed PMID: 1504009. 2: Franchimont P, Almer SM, Charlet-Renard CJ, Daubresse CL, Kicovic PP. Effects of a novel gonadotropin-releasing hormone antagonist (ORG 30850) on gonadotropin and prolactin secretion by rat pituitary cells in culture. Acta Endocrinol (Copenh). 1991 Jan;124(1):98-106. PubMed PMID: 1900380. 3: Gordon K, Scott RT, Williams RF, Danforth DR, Loozen HJ, Kloosterboer HJ, Hodgen GD. In vivo effects of a potent GnRH antagonist ORG 30850: physiologic evidence that down-regulation of GnRH receptors does not occur. J Soc Gynecol Investig. 1994 Oct-Dec;1(4):290-6. PubMed PMID: 9419786. 4: Hakola K, Boogaart PV, Mulders J, de Leeuw R, Schoonen W, Heyst JV, Swolfs A, Casteren JV, Huhtaniemi I, Kloosterboer H. Recombinant rat luteinizing hormone; production by Chinese hamster ovary cells, purification and functional characterization. Mol Cell Endocrinol. 1997 Apr 4;128(1-2):47-56. PubMed PMID: 9140075. 5: Pati D, Habibi HR, Gedamu L. Inhibition of zinc-induced metallothionein mRNA accumulation by gonadotropin-releasing hormone in human hepatocarcinoma cell line HepG2. Eur J Biochem. 1996 Nov 15;242(1):36-40. PubMed PMID: 8954150.