MedKoo Cat#: 465038 | Name: TL13-112
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

TL13-112 shows chemically induced degradation of anaplastic lymphoma kinase (ALK).

Chemical Structure

TL13-112
TL13-112
CAS#2229037-19-6

Theoretical Analysis

MedKoo Cat#: 465038

Name: TL13-112

CAS#: 2229037-19-6

Chemical Formula: C49H60ClN9O10S

Exact Mass: 1001.3872

Molecular Weight: 1002.58

Elemental Analysis: C, 58.70; H, 6.03; Cl, 3.54; N, 12.57; O, 15.96; S, 3.20

Price and Availability

Size Price Availability Quantity
10mg USD 250.00 2 Weeks
25mg USD 450.00 2 Weeks
50mg USD 750.00 2 Weeks
100mg USD 1,250.00 2 Weeks
200mg USD 2,150.00 2 Weeks
500mg USD 3,950.00 2 Weeks
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Related CAS #
2229037-19-6;
Synonym
TL13-112; TL13 112; TL13 112;
IUPAC/Chemical Name
N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)- amino)pyrimidin-2-yl)amino)-5-isopropoxy-2-methylphenyl)- piperidin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin- 3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide
InChi Key
XIRQUXILNXIWDI-UHFFFAOYSA-N
InChi Code
InChI=1S/C49H60ClN9O10S/c1-29(2)69-40-26-34(31(5)25-38(40)55-49-53-27-35(50)45(57-49)54-36-10-6-7-12-41(36)70(65,66)30(3)4)32-15-18-58(19-16-32)20-22-68-24-23-67-21-17-51-43(61)28-52-37-11-8-9-33-44(37)48(64)59(47(33)63)39-13-14-42(60)56-46(39)62/h6-12,25-27,29-30,32,39,52H,13-24,28H2,1-5H3,(H,51,61)(H,56,60,62)(H2,53,54,55,57)
SMILES Code
CC(C)OC1=CC(C2CCN(CCOCCOCCNC(=O)CNC3=CC=CC4=C3C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)=C(C)C=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2S(=O)(=O)C(C)C)=N1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,002.58 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Mura G, Karaca Atabay E, Menotti M, Martinengo C, Ambrogio C, Giacomello G, Arigoni M, Olivero M, Calogero RA, Chiarle R, Voena C. Regulation of CD45 phosphatase by oncogenic ALK in anaplastic large cell lymphoma. Front Oncol. 2023 Jan 9;12:1085672. doi: 10.3389/fonc.2022.1085672. PMID: 36698412; PMCID: PMC9869957.