Bim 21009 | CAS#106881-54-3 | gonadorelin inhibitor

MedKoo Cat#: 598797 | Name: Bim 21009

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Bim 21009 is a gonadorelin inhibitor.

Chemical Structure

Bim 21009

CAS#106881-54-3

Theoretical Analysis

MedKoo Cat#: 598797

Name: Bim 21009

CAS#: 106881-54-3

Chemical Formula: C74H92ClN17O13

Exact Mass: 1461.6749

Molecular Weight: 1463.10

Elemental Analysis: C, 60.75; H, 6.34; Cl, 2.42; N, 16.27; O, 14.22

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Bim 21009; Bim-21009; Bim21009; LHRH-Ncpapa; LHRH Ncpapa; LHRHNcpapa;

IUPAC/Chemical Name

(S)-1-(((R)-2-((R)-2-acetamido-3-(naphthalen-2-yl)propanamido)-3-(4-chlorophenyl)propanoyl)-D-phenylalanyl-L-seryl-L-tyrosyl-D-arginyl-L-phenylalanyl-L-arginyl)-N-((R)-1-amino-1-oxopropan-2-yl)pyrrolidine-2-carboxamide

InChi Key

KNXGSADBVSBWML-OTCVFGFMSA-N

InChi Code

InChI=1S/C74H92ClN17O13/c1-43(63(76)96)83-71(104)62-22-13-35-92(62)72(105)55(21-12-34-82-74(79)80)86-67(100)57(37-45-14-5-3-6-15-45)87-64(97)54(20-11-33-81-73(77)78)85-66(99)59(40-48-26-31-53(95)32-27-48)90-70(103)61(42-93)91-69(102)58(38-46-16-7-4-8-17-46)89-68(101)60(39-47-24-29-52(75)30-25-47)88-65(98)56(84-44(2)94)41-49-23-28-50-18-9-10-19-51(50)36-49/h3-10,14-19,23-32,36,43,54-62,93,95H,11-13,20-22,33-35,37-42H2,1-2H3,(H2,76,96)(H,83,104)(H,84,94)(H,85,99)(H,86,100)(H,87,97)(H,88,98)(H,89,101)(H,90,103)(H,91,102)(H4,77,78,81)(H4,79,80,82)/t43-,54-,55+,56-,57+,58-,59+,60-,61+,62+/m1/s1

SMILES Code

C[C@H](C(N)=O)NC([C@H]1N(C([C@H](CCCNC(N)=N)NC([C@H](CC2=CC=CC=C2)NC([C@@H](CCCNC(N)=N)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CO)NC([C@@H](CC4=CC=CC=C4)NC([C@@H](CC5=CC=C(Cl)C=C5)NC([C@@H](CC6=CC=C7C=CC=CC7=C6)NC(C)=O)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,463.10 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ezan E, Drieu K, Moreau JP, Dray F. Validation in rat plasma of a direct radioimmunoassay for a luteinizing hormone-releasing hormone antagonist (BIM 21009). J Immunoassay. 1990;11(3):295-309. Erratum in: J Immunoassay 1991;12(1):163-4. PubMed PMID: 2229420. 2: Virolainen JV, Love RJ, Tast A, Peltoniemi OA. Effect of a gonadotrophin-releasing hormone antagonist on luteinising hormone secretion and early pregnancy in gilts. Reprod Fertil Dev. 2003;15(7-8):451-9. PubMed PMID: 15018782. 3: Webley GE, Hodges JK, Given A, Hearn JP. Comparison of the luteolytic action of gonadotrophin-releasing hormone antagonist and cloprostenol, and the ability of human chorionic gonadotrophin and melatonin to override their luteolytic effects in the marmoset monkey. J Endocrinol. 1991 Jan;128(1):121-9. PubMed PMID: 1900320. 4: Hodges JK, Green DI, Cottingham PG, Sauer MJ, Edwards C, Lightman SL. Induction of luteal regression in the marmoset monkey (Callithrix jacchus) by a gonadotrophin-releasing hormone antagonist and the effects on subsequent follicular development. J Reprod Fertil. 1988 Mar;82(2):743-52. PubMed PMID: 3129559.