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MedKoo Cat#: 464042 | Name: SM8

Description:

WARNING: This product is for research use only, not for human or veterinary use.

SM8 is a novel inhibitor the oxygen consumption rate (OCR) in both murine and human pluripotent stem cell (PSC).

Chemical Structure

SM8
SM8
CAS#unknown

Theoretical Analysis

MedKoo Cat#: 464042

Name: SM8

CAS#: unknown

Chemical Formula: C32H34N2O2

Exact Mass: 478.2620

Molecular Weight: 478.64

Elemental Analysis: C, 80.30; H, 7.16; N, 5.85; O, 6.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
SM8; SM 8; SM-8;
IUPAC/Chemical Name
3,3''-((((1R,2S)-cyclohexane-1,2-diyl)bis(azanediyl))bis(methylene))bis(([1,1'-biphenyl]-2-ol))
InChi Key
VULDRYBWNMXMBZ-RNPORBBMSA-N
InChi Code
InChI=1S/C32H34N2O2/c35-31-25(15-9-17-27(31)23-11-3-1-4-12-23)21-33-29-19-7-8-20-30(29)34-22-26-16-10-18-28(32(26)36)24-13-5-2-6-14-24/h1-6,9-18,29-30,33-36H,7-8,19-22H2/t29-,30+
SMILES Code
OC1=C(CN[C@H]2[C@@H](NCC3=C(O)C(C4=CC=CC=C4)=CC=C3)CCCC2)C=CC=C1C5=CC=CC=C5
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Solvent mg/mL mM comments
Solubility
Soluble in DMSO 0.0 100.00
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 478.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
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ACS Chem Neurosci. 2019 Mar 20;10(3):1434-1444. doi: 10.1021/acschemneuro.8b00475. Epub 2018 Nov 16. PMID: 30396268. 8: Wang W, Wang X, Zhou S, Xu X, Du J, Zhang L, Mu X, Wei Y, Zhu X, Wang S. Syntheses, Structures, and Catalytic Activities of the Anionic Heterobimetallic Rare-Earth Metal Complexes Supported by Pyrrolyl-Substituted 1,2-Diimino Ligands. Inorg Chem. 2018 Aug 20;57(16):10390-10400. doi: 10.1021/acs.inorgchem.8b01556. Epub 2018 Aug 3. PMID: 30074389. 9: Taylor AE, Bedford MR, Miller HM. The effects of xylanase on grower pig performance, concentrations of volatile fatty acids and peptide YY in portal and peripheral blood. Animal. 2018 Dec;12(12):2499-2504. doi: 10.1017/S1751731118000277. Epub 2018 Mar 6. PMID: 29508681. 10: Setzer WN. Conformational analysis of macrocyclic frankincense (Boswellia) diterpenoids. J Mol Model. 2018 Mar 1;24(3):74. doi: 10.1007/s00894-018-3625-8. PMID: 29492734. 11: Almeida EL, Margassery LM, Kennedy J, Dobson ADW. Draft Genome Sequence of the Antimycin-Producing Bacterium Streptomyces sp. Strain SM8, Isolated from the Marine Sponge Haliclona simulans. Genome Announc. 2018 Jan 25;6(4):e01535-17. doi: 10.1128/genomeA.01535-17. PMID: 29371360; PMCID: PMC5786686. 12: Dąbrowa K, Jurczak J. Tetra-(meta-butylcarbamoyl)azobenzene: A Rationally Designed Photoswitch with Binding Affinity for Oxoanions in a Long-Lived Z-State. Org Lett. 2017 Mar 17;19(6):1378-1381. doi: 10.1021/acs.orglett.7b00267. Epub 2017 Feb 27. PMID: 28240890. 13: Kirikoshi R, Manabe N, Takahashi O. Succinimide Formation from an NGR- Containing Cyclic Peptide: Computational Evidence for Catalytic Roles of Phosphate Buffer and the Arginine Side Chain. Int J Mol Sci. 2017 Feb 16;18(2):429. doi: 10.3390/ijms18020429. PMID: 28212316; PMCID: PMC5343963. 14: Cox CE, Phifer JR, Ferreira da Silva L, Gonçalves Nogueira G, Ley RT, O'Loughlin EJ, Pereira Barbosa AK, Rygelski BT, Paluch AS. Combining MOSCED with molecular simulation free energy calculations or electronic structure calculations to develop an efficient tool for solvent formulation and selection. J Comput Aided Mol Des. 2017 Feb;31(2):183-199. doi: 10.1007/s10822-016-0001-6. Epub 2017 Jan 28. PMID: 28132112. 15: Silva NM, Deglmann P, Pliego JR Jr. CMIRS Solvation Model for Methanol: Parametrization, Testing, and Comparison with SMD, SM8, and COSMO-RS. J Phys Chem B. 2016 Dec 15;120(49):12660-12668. doi: 10.1021/acs.jpcb.6b10249. Epub 2016 Dec 5. PMID: 27973833. 16: Bidaux G, Borowiec AS, Dubois C, Delcourt P, Schulz C, Vanden Abeele F, Lepage G, Desruelles E, Bokhobza A, Dewailly E, Slomianny C, Roudbaraki M, Héliot L, Bonnal JL, Mauroy B, Mariot P, Lemonnier L, Prevarskaya N. Targeting of short TRPM8 isoforms induces 4TM-TRPM8-dependent apoptosis in prostate cancer cells. Oncotarget. 2016 May 17;7(20):29063-80. doi: 10.18632/oncotarget.8666. 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PMID: 25678153. 20: Zanith CC, Pliego JR Jr. Performance of the SMD and SM8 models for predicting solvation free energy of neutral solutes in methanol, dimethyl sulfoxide and acetonitrile. J Comput Aided Mol Des. 2015 Mar;29(3):217-24. doi: 10.1007/s10822-014-9814-3. Epub 2014 Nov 15. PMID: 25398641.