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MedKoo Cat#: 598796 | Name: Folligen

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Folligen is a novel gonadotropin-releasing hormone analogue against DMBA-induced tumours in the rat.

Chemical Structure

Folligen
Folligen
CAS#103631-79-4

Theoretical Analysis

MedKoo Cat#: 598796

Name: Folligen

CAS#: 103631-79-4

Chemical Formula: C61H78N14O13

Exact Mass: 1214.5873

Molecular Weight: 1215.38

Elemental Analysis: C, 60.28; H, 6.47; N, 16.13; O, 17.11

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
Folligen;
IUPAC/Chemical Name
(S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-21-(3-amino-3-oxopropyl)-15-benzyl-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-18-isobutyl-1,4,7,10,13,16,19-heptaoxo-1-((R)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-ethylpyrrolidine-2-carboxamide
InChi Key
FVGGCEANXXPWAJ-YXIHLITBSA-N
InChi Code
1S/C61H78N14O13/c1-4-64-60(87)50-15-10-24-75(50)61(88)43(20-22-51(62)78)68-54(81)44(25-34(2)3)69-55(82)45(26-35-11-6-5-7-12-35)70-56(83)46(27-36-16-18-39(77)19-17-36)71-59(86)49(32-76)74-57(84)47(28-37-30-65-41-14-9-8-13-40(37)41)72-58(85)48(29-38-31-63-33-66-38)73-53(80)42-21-23-52(79)67-42/h5-9,11-14,16-19,30-31,33-34,42-50,65,76-77H,4,10,15,20-29,32H2,1-3H3,(H2,62,78)(H,63,66)(H,64,87)(H,67,79)(H,68,81)(H,69,82)(H,70,83)(H,71,86)(H,72,85)(H,73,80)(H,74,84)/t42?,43-,44-,45+,46-,47-,48-,49-,50-/m0/s1
SMILES Code
O=C(N[C@@H](Cc(c[nH]1)c2c1cccc2)C(N[C@H](C(N[C@@H](Cc3ccc(O)cc3)C(N[C@H](Cc4ccccc4)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N5[C@H](C(NCC)=O)CCC5)=O)=O)=O)=O)=O)CO)=O)[C@H](Cc6[nH]cnc6)NC([C@@H](CC7)NC7=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,215.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Nicholson RI, Kéri G. Antitumour activity of folligen, a novel gonadotropin-releasing hormone analogue against DMBA-induced tumours in the rat. Tumour Biol. 1992;13(1-2):44-50. PubMed PMID: 1534181. 2: Kéri G, Balogh A, Szöke B, Teplán I, Csuka O. Gonadotropin-releasing hormone analogues inhibit cell proliferation and activate signal transduction pathways in MDA-MB-231 human breast cancer cell line. Tumour Biol. 1991;12(2):61-7. PubMed PMID: 1902971. 3: Teplán I. Peptides and antitumor activity. Development and investigation of some peptides with antitumor activity. Acta Biol Hung. 2000;51(1):1-29. Review. PubMed PMID: 10866357. 4: Kéri G, Balogh A, Horváth A, Mezö I, Vadász Z, Bökönyi G, Bajor T, Vántus T, Teplán I, Horváth J, et al. Novel antitumor peptide hormones and their effect on signal transduction. J Steroid Biochem Mol Biol. 1992 Sep;43(1-3):105-10. PubMed PMID: 1356011. 5: Horvath JE, Kéri G, Seprödi A, Teplán I, Flerkó B. Desensitization of pituitary cells by gonadotrophin-releasing hormone or its analogues in the superfusion system: different pattern for males and females. J Neuroendocrinol. 1992 Oct;4(5):565-73. doi: 10.1111/j.1365-2826.1992.tb00205.x. PubMed PMID: 21554641. 6: Török A, Hamori M, Bódis J, Cledon P, Tinneberg HR, Hanf V. Effect of LHRH and its analogues on the progesterone secretion of human granulosa cells in vitro. Gynecol Obstet Invest. 1992;34(4):222-4. PubMed PMID: 1487180.