MedKoo Cat#: 563513 | Name: CNQX Disodium
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

CNQX Disodium is a water-soluble form of AMPA/kainate antagonist CNQX.

Chemical Structure

CNQX Disodium
CNQX Disodium
CAS#479347-85-8 (sodium)

Theoretical Analysis

MedKoo Cat#: 563513

Name: CNQX Disodium

CAS#: 479347-85-8 (sodium)

Chemical Formula: C9H2N4Na2O4

Exact Mass: 275.9871

Molecular Weight: 276.11

Elemental Analysis: C, 39.15; H, 0.73; N, 20.29; Na, 16.65; O, 23.18

Price and Availability

Size Price Availability Quantity
10mg USD 350.00 2 Weeks
25mg USD 600.00 2 Weeks
50mg USD 950.00 2 Weeks
100mg USD 1,450.00 2 Weeks
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Related CAS #
115066-14-3 (free acid) 479347-85-8 (sodium)
Synonym
CNQX Disodium; CNQX 2Na;
IUPAC/Chemical Name
sodium 6-cyano-7-nitroquinoxaline-2,3-bis(olate)
InChi Key
YCXDDPGRZKUGDG-UHFFFAOYSA-L
InChi Code
InChI=1S/C9H4N4O4.2Na/c10-3-4-1-5-6(2-7(4)13(16)17)12-9(15)8(14)11-5;;/h1-2H,(H,11,14)(H,12,15);;/q;2*+1/p-2
SMILES Code
N#CC1=C([N+]([O-])=O)C=C2N=C([O-])C([O-])=NC2=C1.[Na+].[Na+]
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 276.11 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sergeeva OA, De Luca R, Mazur K, Chepkova AN, Haas HL, Bauer A. N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms. Neuropharmacology. 2017 Jun;119:111-122. doi: 10.1016/j.neuropharm.2017.04.011. Epub 2017 Apr 9. PubMed PMID: 28400256. 2: Blasiak A, Siwiec M, Grabowiecka A, Blasiak T, Czerw A, Blasiak E, Kania A, Rajfur Z, Lewandowski MH, Gundlach AL. Excitatory orexinergic innervation of rat nucleus incertus--Implications for ascending arousal, motivation and feeding control. Neuropharmacology. 2015 Dec;99:432-47. doi: 10.1016/j.neuropharm.2015.08.014. Epub 2015 Aug 8. PubMed PMID: 26265304. 3: Zăgrean AM, Spataru A, Ceangă M, Zăgrean L. The single versus combinatorial effects of MK-801, CNQX, Nifedipine and AP-3 on primary cultures of cerebellar granule cells in an oxygen-glucose deprivation model. Rom J Morphol Embryol. 2014;55(3):811-6. PubMed PMID: 25329107. 4: Gigout S, Louvel J, Rinaldi D, Martin B, Pumain R. Thalamocortical relationships and network synchronization in a new genetic model "in mirror" for absence epilepsy. Brain Res. 2013 Aug 7;1525:39-52. doi: 10.1016/j.brainres.2013.05.044. Epub 2013 Jun 3. PubMed PMID: 23743261. 5: Ferreira-Neto HC, Yao ST, Antunes VR. Purinergic and glutamatergic interactions in the hypothalamic paraventricular nucleus modulate sympathetic outflow. Purinergic Signal. 2013 Sep;9(3):337-49. doi: 10.1007/s11302-013-9352-9. Epub 2013 Feb 12. PubMed PMID: 23400372; PubMed Central PMCID: PMC3757145. 6: Geborek P, Jörntell H, Bengtsson F. Stimulation within the cuneate nucleus suppresses synaptic activation of climbing fibers. Front Neural Circuits. 2013 Jan 17;6:120. doi: 10.3389/fncir.2012.00120. eCollection 2012. PubMed PMID: 23335886; PubMed Central PMCID: PMC3547372. 7: Spuz CA, Borszcz GS. NMDA or non-NMDA receptor antagonism within the amygdaloid central nucleus suppresses the affective dimension of pain in rats: evidence for hemispheric synergy. J Pain. 2012 Apr;13(4):328-37. doi: 10.1016/j.jpain.2011.12.007. Epub 2012 Mar 15. PubMed PMID: 22424916; PubMed Central PMCID: PMC3329962. 8: Hirota R, Kondo M, Ueno S, Sakai T, Koyasu T, Terasaki H. Photoreceptor and post-photoreceptoral contributions to photopic ERG a-wave in rhodopsin P347L transgenic rabbits. Invest Ophthalmol Vis Sci. 2012 Mar 15;53(3):1467-72. doi: 10.1167/iovs.11-9006. PubMed PMID: 22273723. 9: Banasikowski TJ, MacLeod LS, Beninger RJ. Comparison of nafadotride, CNQX, and haloperidol on acquisition versus expression of amphetamine-conditioned place preference in rats. Behav Pharmacol. 2012 Feb;23(1):89-97. doi: 10.1097/FBP.0b013e32834ecb32. PubMed PMID: 22157177. 10: Kernig K, Kirschstein T, Würdemann T, Rohde M, Köhling R. The afterhyperpolarizing potential following a train of action potentials is suppressed in an acute epilepsy model in the rat Cornu Ammonis 1 area. Neuroscience. 2012 Jan 10;201:288-96. doi: 10.1016/j.neuroscience.2011.11.008. Epub 2011 Nov 10. PubMed PMID: 22100272. 11: Harte SE, Spuz CA, Borszcz GS. Functional interaction between medial thalamus and rostral anterior cingulate cortex in the suppression of pain affect. Neuroscience. 2011 Jan 13;172:460-73. doi: 10.1016/j.neuroscience.2010.10.055. Epub 2010 Oct 27. PubMed PMID: 21034797; PubMed Central PMCID: PMC3030197. 12: Westerholz S, de Lima AD, Voigt T. Regulation of early spontaneous network activity and GABAergic neurons development by thyroid hormone. Neuroscience. 2010 Jun 30;168(2):573-89. doi: 10.1016/j.neuroscience.2010.03.039. Epub 2010 Mar 23. PubMed PMID: 20338226. 13: Brunet N, Tarabal O, Esquerda JE, Calderó J. Excitotoxic motoneuron degeneration induced by glutamate receptor agonists and mitochondrial toxins in organotypic cultures of chick embryo spinal cord. J Comp Neurol. 2009 Oct 1;516(4):277-90. doi: 10.1002/cne.22118. PubMed PMID: 19634179. 14: Bodnár I, Bánky Z, Zelena D, Halász B. Glutamate receptor antagonist infused into the hypothalamic suprachiasmatic nuclei interferes with the diurnal fluctuations in plasma prolactin and corticosterone levels and injected into the mesencephalic dorsal raphe nucleus attenuates the suckling stimulus-induced release of prolactin of the rat. Brain Res Bull. 2009 Aug 28;80(1-2):9-16. doi: 10.1016/j.brainresbull.2009.06.005. Epub 2009 Jun 17. PubMed PMID: 19539728. 15: Biondolillo JW, Williams LA, King MS. Blocking glutamate receptors in the waist area of the parabrachial nucleus decreases taste reactivity behaviors in conscious rats. Chem Senses. 2009 Mar;34(3):221-30. doi: 10.1093/chemse/bjn081. Epub 2009 Jan 27. PubMed PMID: 19174448; PubMed Central PMCID: PMC2642472. 16: Sepehrizadeh Z, Bahrololoumi Shapourabadi M, Ahmadi S, Hashemi Bozchlou S, Zarrindast MR, Sahebgharani M. Decreased AMPA GluR2, but not GluR3, mRNA expression in rat amygdala and dorsal hippocampus following morphine-induced behavioural sensitization. Clin Exp Pharmacol Physiol. 2008 Nov;35(11):1321-30. doi: 10.1111/j.1440-1681.2008.05004.x. Epub 2008 Jul 29. PubMed PMID: 18671727. 17: Kelly T, Mann M, Church J. The slow afterhyperpolarization modulates high pH-induced changes in the excitability of rat CA1 pyramidal neurons. Eur J Neurosci. 2007 Nov;26(10):2844-56. PubMed PMID: 18001281. 18: Balázsa T, Bíró J, Gullai N, Ledent C, Sperlágh B. CB1-cannabinoid receptors are involved in the modulation of non-synaptic [3H]serotonin release from the rat hippocampus. Neurochem Int. 2008 Jan;52(1-2):95-102. Epub 2007 Jul 14. PubMed PMID: 17719142. 19: Ma X, Bruning J, Ashcroft FM. Glucagon-like peptide 1 stimulates hypothalamic proopiomelanocortin neurons. J Neurosci. 2007 Jul 4;27(27):7125-9. Retraction in: J Neurosci. 2011 Jun 8;31(23):8698. PubMed PMID: 17611265; PubMed Central PMCID: PMC3868967. 20: Sasaki T, Kaneko A. Elevation of intracellular ca(2+) concentration induced by hypoxia in retinal ganglion cells. Jpn J Ophthalmol. 2007 May-Jun;51(3):175-80. Epub 2007 Jun 7. PubMed PMID: 17554478.