Propineb | CAS#12071-83-9 | fungicide

MedKoo Cat#: 598786 | Name: Propineb

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Propineb is used as a fungicide.

Chemical Structure

Propineb

CAS#12071-83-9

Theoretical Analysis

MedKoo Cat#: 598786

Name: Propineb

CAS#: 12071-83-9

Chemical Formula: C5H8N2S4Zn

Exact Mass: 287.8862

Molecular Weight: 289.75

Elemental Analysis: C, 20.73; H, 2.78; N, 9.67; S, 44.26; Zn, 22.56

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 290.00
1g	USD 410.00
25g	USD 700.00

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Related CAS #

No Data

Synonym

Propineb; LH 3012; LH-3012; LH3012; Tsipromat; Mezineb; Methylzineb;

IUPAC/Chemical Name

Zinc, (N,N'-propylene-1,2-bis(dithiocarbamate))

InChi Key

KKMLIVYBGSAJPM-AENDTGMFSA-L

InChi Code

InChI=1S/C5H10N2S4.Zn/c1-3(7-5(10)11)2-6-4(8)9;/h3H,2H2,1H3,(H2,6,8,9)(H2,7,10,11);/q;+2/p-2/t3-;/m1./s1

SMILES Code

S=C(S[Zn]S1)NC[C@@H](C)NC1=S

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 289.75 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Rasgele PG, Muranli FD, Kekeçoğlu M. Assessment of the genotoxicity of propineb in mice bone marrow cells using micronucleus assay. Tsitol Genet. 2014 Jul-Aug;48(4):39-43. PubMed PMID: 25181854. 2: Rasgele PG. Abnormal sperm morphology in mouse germ cells after short-term exposures to acetamiprid, propineb, and their mixture. Arh Hig Rada Toksikol. 2014 Mar;65(1):47-56. doi: 10.2478/10004-1254-65-2014-2408. PubMed PMID: 24535295. 3: Banerjee H, Ganguly P, Roy S, Banerjee D, Paramasivam M, Banerjee T, Sharma KK. Persistence and safety risk assessment of propineb in Indian tea. Environ Monit Assess. 2010 Nov;170(1-4):311-4. doi: 10.1007/s10661-009-1234-9. Epub 2009 Nov 13. PubMed PMID: 19911290. 4: Pal DS, Mondal DK, Datta R. Identification of metal dithiocarbamates as a novel class of antileishmanial agents. Antimicrob Agents Chemother. 2015 Apr;59(4):2144-52. doi: 10.1128/AAC.05146-14. Epub 2015 Jan 26. PubMed PMID: 25624329; PubMed Central PMCID: PMC4356755. 5: Parihar NS, Sharma BN. Persistence of propineb (polymeric zinc 1,2-propylene bisdithiocarbamate) fungicide in onion and cropped soil. Bull Environ Contam Toxicol. 2011 May;86(5):545-7. doi: 10.1007/s00128-011-0256-5. Epub 2011 Mar 27. PubMed PMID: 21442209. 6: Viviani B, Bartesaghi S, Binaglia M, Corsini E, Boraso M, Grazi E, Galli CL, Marinovich M. Dithiocarbamate propineb induces acetylcholine release through cytoskeletal actin depolymerization in PC12 cells. Toxicol Lett. 2008 Nov 10;182(1-3):63-8. doi: 10.1016/j.toxlet.2008.08.016. Epub 2008 Sep 4. PubMed PMID: 18822360. 7: Pauluhn J, Rosenbruch M. Inhalation toxicity of propineb. Part I: Results of subacute inhalation exposure studies in rats. Inhal Toxicol. 2003 Apr 25;15(5):411-34. PubMed PMID: 12682856. 8: Pauluhn J, Emura M, Mohr U, Rosenbruch M. Inhalation toxicity of propineb. Part II: Results of mechanistic studies in rats. Inhal Toxicol. 2003 Apr 25;15(5):435-60. PubMed PMID: 12682857. 9: Marinovich M, Viviani B, Capra V, Corsini E, Anselmi L, D'Agostino G, Di Nucci A, Binaglia M, Tonini M, Galli CL. Facilitation of acetylcholine signaling by the dithiocarbamate fungicide propineb. Chem Res Toxicol. 2002 Jan;15(1):26-32. PubMed PMID: 11800594. 10: Yaldiz M, Akdeniz S, Bilgin UY, Deveci E, Akkuş M, Kilinç M, Deveci S. Teratogenic effects of propineb on rat skin. Clin Exp Obstet Gynecol. 2000;27(3-4):235-7. PubMed PMID: 11214962. 11: Kazos EA, Stalikas CD, Nanos CG, Konidari CN. Determination of dithiocarbamate fungicide propineb and its main metabolite propylenethiourea in airborne samples. Chemosphere. 2007 Aug;68(11):2104-10. Epub 2007 Mar 21. PubMed PMID: 17376506. 12: Nishioka K, Takahata H. Contact allergy due to propineb. Contact Dermatitis. 2000 Nov;43(5):310. PubMed PMID: 11016679. 13: Quinto I, De Marinis E. Evaluation of Propineb, a dithiocarbamate pesticide, in the mouse-sperm morphology assay. Mutat Res. 1983 Dec;124(3-4):235-40. PubMed PMID: 6656825. 14: Guven K, Deveci E, Akba O, Onen A, de Pomerai D. The accumulation and histological effects of organometallic fungicides Propineb and Maneb in the kidneys of fetus and female rats during pregnancy. Toxicol Lett. 1998 Oct 15;99(2):91-8. PubMed PMID: 9817080. 15: Rolandi A, De Marinis E, De Caterina M. Dithiocarbamate pesticides: activity of Propineb in the micronucleus test in mice. Mutat Res. 1984 Mar;135(3):193-7. PubMed PMID: 6424007. 16: Yu XB, Hao K, Ling F, Wang GX. Aquatic environmental safety assessment and inhibition mechanism of chemicals for targeting Microcystis aeruginosa. Ecotoxicology. 2014 Nov;23(9):1638-47. doi: 10.1007/s10646-014-1303-x. Epub 2014 Aug 20. PubMed PMID: 25139029. 17: Deveci E, Guven K, Bashan M, Onen A, de Pomerai D. The accumulation and histological effects of organometallic fungicides propineb and maneb in the livers of pregnant rats and their offspring. J Toxicol Sci. 1999 May;24(2):79-85. PubMed PMID: 10349609. 18: Schmuck G, Ahr HJ, Mihail F, Stahl B, Kayser M. Effects of the dithiocarbamate fungicide propineb in primary neuronal cell cultures and skeletal muscle cells of the rat. Arch Toxicol. 2002 Jul;76(7):414-22. Epub 2002 May 29. PubMed PMID: 12111006. 19: Vicari L, De Dominicis G, Vito M, Placida C, De Marinis E. [Teratogenic and goitrogenic activity of propineb and propylenethiourea in the rat]. Boll Soc Ital Biol Sper. 1985 Feb 28;61(2):271-8. Italian. PubMed PMID: 2581594. 20: Larsson KS, Arnander C, Cekanova E, Kjellberg M. Studies of teratogenic effects of the dithiocarbamates maneb, mancozeb, and propineb. Teratology. 1976 Oct;14(2):171-83. PubMed PMID: 982313.