RJS308 | PROTAC

MedKoo Cat#: 128476 | Name: RJS308

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RJS308 is a PROTAC designed to target cyclophilin A (CypA), and it exhibits several important bioactivities: In Jurkat cells, RJS308 potently degrades CypA.

Chemical Structure

RJS308

CAS#N/A

Theoretical Analysis

MedKoo Cat#: 128476

Name: RJS308

CAS#: N/A

Chemical Formula: C63H75N13O11S

Exact Mass: 1221.5430

Molecular Weight: 1222.43

Elemental Analysis: C, 61.90; H, 6.18; N, 14.90; O, 14.40; S, 2.62

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

RJS308; RJS 308; RJS-308

IUPAC/Chemical Name

(2S,4R)-1-((2S)-3,3-dimethyl-2-(6-(4-(((53S,2R,7S,10S,E)-2-methyl-10-(4-nitrobenzyl)-4,6,9,12-tetraoxo-51,52,53,54,55,56-hexahydro-3-oxa-8,11-diaza-1(2,7)-quinolina-5(3,1)-pyridazinacyclopentadecaphan-14-en-7-yl)methyl)-1H-1,2,3-triazol-1-yl)hexanamido)butanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide

InChi Key

FOWOXSIJPRPEMY-NFKPPNCFSA-N

InChi Code

InChI=1S/C63H75N13O11S/c1-37(42-20-22-44(23-21-42)56-38(2)64-36-88-56)65-59(81)53-33-47(77)35-74(53)61(83)57(63(4,5)6)69-55(79)14-8-7-9-28-73-34-45(70-72-73)32-52-60(82)75-29-11-13-49(71-75)62(84)87-39(3)48-27-24-43-19-16-40(30-50(43)66-48)12-10-15-54(78)67-51(58(80)68-52)31-41-17-25-46(26-18-41)76(85)86/h10,12,16-27,30,34,36-37,39,47,49,51-53,57,71,77H,7-9,11,13-15,28-29,31-33,35H2,1-6H3,(H,65,81)(H,67,78)(H,68,80)(H,69,79)/b12-10+/t37-,39+,47+,49-,51-,52-,53-,57+/m0/s1

SMILES Code

O=C(O[C@@H]1C)[C@@H]2CCCN(C([C@H](CC3=CN(CCCCCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)N=N3)NC([C@H](CC7=CC=C([N+]([O-])=O)C=C7)NC(C/C=C/C8=CC9=C(C=C8)C=CC1=N9)=O)=O)=O)N2

Appearance

To be determined

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).

Solubility

To be determined

Shelf Life

>2 years if stored properly

Drug Formulation

To be determined

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 1,222.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Newton LS, Gathmann C, Ridewood S, Smith RJ, Wijaya AJ, Hornsby TW, Morling KL, Annett D, Chiozzi RZ, Reuschl AK, Govasli ML, Tan YY, Thorne LG, Jolly C, Thalassinos K, Ciulli A, Towers GJ, Selwood DL. Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16(1):1484. doi: 10.1038/s41467-025-56317-8. PMID: 39929804; PMCID: PMC11811207.