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MedKoo Cat#: 598777 | Name: LG 83-6-05

Description:

WARNING: This product is for research use only, not for human or veterinary use.

LG 83-6-05 is a novel sodium channel blocking agent.

Chemical Structure

LG 83-6-05
LG 83-6-05
CAS#131602-24-9

Theoretical Analysis

MedKoo Cat#: 598777

Name: LG 83-6-05

CAS#: 131602-24-9

Chemical Formula: C21H29NO3S

Exact Mass: 375.1868

Molecular Weight: 375.53

Elemental Analysis: C, 67.17; H, 7.78; N, 3.73; O, 12.78; S, 8.54

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
LG 83-6-05; LG-83-6-05; LG83-6-05; LG-83605; LG 83605; LG83605;
IUPAC/Chemical Name
1-(3-(2-hydroxy-3-(isobutylamino)propoxy)-4-methylthiophen-2-yl)-3-phenylpropan-1-one
InChi Key
YDXYOAAMYRVKSZ-UHFFFAOYSA-N
InChi Code
InChI=1S/C21H29NO3S/c1-15(2)11-22-12-18(23)13-25-20-16(3)14-26-21(20)19(24)10-9-17-7-5-4-6-8-17/h4-8,14-15,18,22-23H,9-13H2,1-3H3
SMILES Code
O=C(C1=C(OCC(O)CNCC(C)C)C(C)=CS1)CCC2=CC=CC=C2
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
LG 83-6-05 is a novel sodium channel blocking agent.
In vitro activity:
TBD
In vivo activity:
In enzymatically-dispersed single ventricular cardiomyocytes of adult rats and guinea pigs the inhibition of the cardiac sodium current by a novel sodium channel blocking agent (LG 83-6-05, 1-[3-(2-Hydroxy-3-(2-methylpropylamino)-propoxy)-4-methyl-2- thienyl++ ]-3-phenyl-1-propanon hydrochloride) was studied. A single-electrode voltage-clamp system (switch clamping, patch electrodes) was used to measure action potentials as well as ionic currents during voltage-clamp experiments. In addition single channel measurements were performed using the patch-clamp technique. The single cell system enabled this study to demonstrate that LG 83-6-05 is an inhibitor of the cardiac sodium current. Reference: Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. https://pubmed.ncbi.nlm.nih.gov/1965329/

Preparing Stock Solutions

The following data is based on the product molecular weight 375.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Koidl B, Schreibmayer W, Wolf P, Tritthart HA. Inhibition of the fast sodium inward current in ventricular cardiomyocytes of rats and guinea pigs by a novel potent sodium channel blocking agent. Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. doi: 10.1007/BF00169049. PMID: 1965329.
In vitro protocol:
TBD
In vivo protocol:
1. Koidl B, Schreibmayer W, Wolf P, Tritthart HA. Inhibition of the fast sodium inward current in ventricular cardiomyocytes of rats and guinea pigs by a novel potent sodium channel blocking agent. Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. doi: 10.1007/BF00169049. PMID: 1965329.
1: Koidl B, Schreibmayer W, Wolf P, Tritthart HA. Inhibition of the fast sodium inward current in ventricular cardiomyocytes of rats and guinea pigs by a novel potent sodium channel blocking agent. Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):582-91. PubMed PMID: 1965329.

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