MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 598742 | Name: FR-008I

Description:

WARNING: This product is for research use only, not for human or veterinary use.

FR-008I is an antibiotic.

Chemical Structure

FR-008I
FR-008I
CAS#58591-23-4

Theoretical Analysis

MedKoo Cat#: 598742

Name: FR-008I

CAS#: 58591-23-4

Chemical Formula: C59H86N2O18

Exact Mass: 1110.5876

Molecular Weight: 1111.33

Elemental Analysis: C, 63.77; H, 7.80; N, 2.52; O, 25.91

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
FR-008I; FR 008I; FR008I;
IUPAC/Chemical Name
(10R,12S,14S,18S,19S,20S,22R,23E,25E,27E,29Z,31Z,33E,35E,37S,38R)-22-(((2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-38-((2S,4S,5S)-7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl)-4,10,12,14,18,20-hexahydroxy-37-methyl-2,8,16-trioxooxacyclooctatriaconta-23,25,27,29,31,33,35-heptaene-19-carboxylic acid
InChi Key
BVEQUWMYNKLPDF-SJCAJVGYSA-N
InChi Code
InChI=1S/C59H86N2O18/c1-35-18-15-13-11-9-7-5-6-8-10-12-14-16-21-47(78-59-56(74)54(61)55(73)38(4)77-59)33-51(71)53(58(75)76)50(70)31-46(67)30-45(66)29-44(65)28-43(64)27-41(62)19-17-20-42(63)32-52(72)79-57(35)37(3)26-36(2)48(68)34-49(69)39-22-24-40(60)25-23-39/h5-16,18,21-25,35-38,42-45,47-48,50-51,53-57,59,63-66,68,70-71,73-74H,17,19-20,26-34,60-61H2,1-4H3,(H,75,76)/b6-5-,9-7-,10-8+,13-11+,14-12+,18-15+,21-16+/t35-,36-,37-,38+,42?,43-,44-,45-,47-,48-,50-,51-,53+,54-,55+,56-,57-,59-/m0/s1
SMILES Code
C[C@H]([C@H](CC(c1ccc(N)cc1)=O)O)C[C@@H]([C@H]2OC(CC(CCCC(C[C@@H](C[C@@H](C[C@@H](CC(C[C@@H]([C@@H](C(O)=O)[C@H](C[C@H](/C=C/C=C/C=C/C=C\C=C/C=C/C=C/[C@@H]2C)O[C@@H]3O[C@@H]([C@H]([C@@H]([C@@H]3O)N)O)C)O)O)=O)O)O)O)=O)O)=O)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,111.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Afghani E, Akshintala VS, Khashab MA, Law JK, Hutfless SM, Kim KJ, Lennon AM, Kalloo AN, Singh VK. 5-Fr vs. 3-Fr pancreatic stents for the prevention of post-ERCP pancreatitis in high-risk patients: a systematic review and network meta-analysis. Endoscopy. 2014 Jul;46(7):573-80. doi: 10.1055/s-0034-1365701. Epub 2014 May 15. Review. PubMed PMID: 24830399. 2: Macdonald GZ, Button DC, Drinkwater EJ, Behm DG. Foam rolling as a recovery tool after an intense bout of physical activity. Med Sci Sports Exerc. 2014 Jan;46(1):131-42. doi: 10.1249/MSS.0b013e3182a123db. PubMed PMID: 24343353. 3: Honda T, Fujimoto K, Miyao Y. Feasibility of virtual 3-Fr percutaneous coronary intervention using standard guiding catheters. Postepy Kardiol Interwencyjnej. 2014;10(4):231-7. doi: 10.5114/pwki.2014.46763. Epub 2014 Nov 17. PubMed PMID: 25489315; PubMed Central PMCID: PMC4252319. 4: Sage PT, Sharpe AH. In vitro assay to sensitively measure T(FR) suppressive capacity and T(FH) stimulation of B cell responses. Methods Mol Biol. 2015;1291:151-60. doi: 10.1007/978-1-4939-2498-1_13. PubMed PMID: 25836309. 5: Ishigaki T, Sasaki T, Serikawa M, Minami T, Okazaki A, Yukutake M, Ishii Y, Kosaka K, Mouri T, Yoshimi S, Chayama K. Comparative study of 4 Fr versus 6 Fr nasobiliary drainage catheters: a randomized, controlled trial. J Gastroenterol Hepatol. 2014 Mar;29(3):653-9. doi: 10.1111/jgh.12427. PubMed PMID: 24219852. 6: Ashikaga T, Sakurai K, Satoh Y, Inagaki H, Yoshikawa S, Kurihara K, Hirao K, Isobe M. Mother-child technique using a novel 4 Fr inner catheter. EuroIntervention. 2015 Apr;10(12):1432-9. doi: 10.4244/EIJY14M07_19. PubMed PMID: 25058487. 7: Liu Q, Xiao L, Zhou Y, Deng K, Tan G, Han Y, Liu X, Deng Z, Liu T. Development of Streptomyces sp. FR-008 as an emerging chassis. Synth Syst Biotechnol. 2016 Aug 17;1(3):207-214. doi: 10.1016/j.synbio.2016.07.002. eCollection 2016 Sep. PubMed PMID: 29062944; PubMed Central PMCID: PMC5640794. 8: Zhang P, Zhao Z, Li H, Chen XL, Deng Z, Bai L, Pang X. Production of the antibiotic FR-008/candicidin in Streptomyces sp. FR-008 is co-regulated by two regulators, FscRI and FscRIV, from different transcription factor families. Microbiology. 2015 Mar;161(Pt 3):539-52. doi: 10.1099/mic.0.000033. Epub 2015 Jan 9. PubMed PMID: 25575546. 9: Mouri T, Sasaki T, Serikawa M, Ishigaki T, Ishii Y, Shimizu A, Tsuboi T, Kurihara K, Tatsukawa Y, Miyaki E, Kawamura R, Tsushima K, Chayama K. A comparison of 4-Fr with 5-Fr endoscopic nasopancreatic drainage catheters: A randomized, controlled trial. J Gastroenterol Hepatol. 2016 Oct;31(10):1783-1789. doi: 10.1111/jgh.13314. PubMed PMID: 26865332. 10: Stenberg B, Bruze M, Zimerson E. Is p-tert-butylphenol-formaldehyde resin (PTBP-FR) in TRUE Test® (Mekos test) sensitizing the tested patients? Contact Dermatitis. 2015 Dec;73(6):350-7. doi: 10.1111/cod.12401. Epub 2015 Apr 23. PubMed PMID: 25903478. 11: Sharif NA, Katoli P, Scott D, Li L, Kelly C, Xu S, Husain S, Toris C, Crosson C. FR-190997, a nonpeptide bradykinin B2-receptor partial agonist, is a potent and efficacious intraocular pressure lowering agent in ocular hypertensive cynomolgus monkeys. Drug Dev Res. 2014 Jun;75(4):211-23. doi: 10.1002/ddr.21174. Epub 2014 May 2. PubMed PMID: 24796320. 12: Fujisawa T, Kagawa K, Watanabe S, Hisatomi K, Kubota K, Sato H, Nakajima A, Matsuhashi N. Endoscopic nasobiliary drainage for obstructive jaundice using either a 5 Fr or 7 Fr catheter: a prospective, randomized trial. BMC Gastroenterol. 2014 Sep 18;14:161. doi: 10.1186/1471-230X-14-161. PubMed PMID: 25234181; PubMed Central PMCID: PMC4175279. 13: Tonomura D, Shimada Y, Yano K, Ito K, Takehara K, Kino N, Furubayashi K, Kurotobi T, Tsuchida T, Fukumoto H. Feasibility and safety of a virtual 3-Fr sheathless-guiding system for percutaneous coronary intervention. Catheter Cardiovasc Interv. 2014 Sep 1;84(3):426-35. doi: 10.1002/ccd.25357. Epub 2014 Feb 4. PubMed PMID: 24497466. 14: Škarabot J, Beardsley C, Štirn I. Comparing the effects of self-myofascial release with static stretching on ankle range-of-motion in adolescent athletes. Int J Sports Phys Ther. 2015 Apr;10(2):203-12. PubMed PMID: 25883869; PubMed Central PMCID: PMC4387728. 15: Fujii T, Masuda N, Ijichi T, Kamiyama Y, Tanaka S, Nakazawa G, Shinozaki N, Matsukage T, Ogata N, Ikari Y. Feasibility of 6 Fr intra-aortic balloon pumping via the femoral or brachial approach. J Invasive Cardiol. 2012 Dec;24(12):641-4. PubMed PMID: 23220978. 16: Takeshita S, Matsumi J, Saito S. Renal artery intervention using a virtual 4.5-Fr guiding catheter. Catheter Cardiovasc Interv. 2013 May;81(6):1043-6. doi: 10.1002/ccd.24484. Epub 2012 Nov 12. PubMed PMID: 22581581. 17: Angelieri F, Franchi L, Cevidanes LH, Scanavini MA, McNamara JA Jr. Long-term treatment effects of the FR-2 appliance: a prospective evalution 7 years post-treatment. Eur J Orthod. 2014 Apr;36(2):192-9. doi: 10.1093/ejo/cjt026. Epub 2013 Jun 4. PubMed PMID: 23736378; PubMed Central PMCID: PMC4102916. 18: Chodór P, Morawski S, Sulik-Gajda S, Ramus N, Kowalczyk J, Honisz G, Wilczek K, Sredniawa B, Kalarus Z. Evaluation of the usefulness of coronary catheters and 4 Fr insertion sets for transradial access coronarography in comparison with catheters and 5 Fr sets. Postepy Kardiol Interwencyjnej. 2013;9(4):332-6. doi: 10.5114/pwki.2013.38860. Epub 2013 Nov 18. PubMed PMID: 24570748; PubMed Central PMCID: PMC3927104. 19: Wiesner J, Ziemann C, Hintz M, Reichenberg A, Ortmann R, Schlitzer M, Fuhst R, Timmesfeld N, Vilcinskas A, Jomaa H. FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity. Virulence. 2016 Aug 17;7(6):718-28. doi: 10.1080/21505594.2016.1195537. Epub 2016 Jun 3. PubMed PMID: 27260413; PubMed Central PMCID: PMC4991342. 20: Hamann CR, Zimerson E, Hamann D, Laugesen L, Carlsson B, Nathansen C, Hamann C, Bruze M. Concentration variability of potent allergens of p-tert-butylphenol-formaldehyde resin (PTBP-FR) in patch test preparations and commercially available PTBP-FR. Br J Dermatol. 2012 Apr;166(4):761-70. doi: 10.1111/j.1365-2133.2011.10781.x. Epub 2012 Mar 12. PubMed PMID: 22182485.

View History

RS 1893

RS 1893