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MedKoo Cat#: 461407 | Name: Ornoprostil

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Ornoprostil is a prostaglandin E1 analogue that acts as a mucosal protectant.

Chemical Structure

Ornoprostil
Ornoprostil
CAS#70667-26-4

Theoretical Analysis

MedKoo Cat#: 461407

Name: Ornoprostil

CAS#: 70667-26-4

Chemical Formula: C23H38O6

Exact Mass: 410.2668

Molecular Weight: 410.55

Elemental Analysis: C, 67.29; H, 9.33; O, 23.38

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Ornoprostil; Ronoprost; OU 1308; OU-1308; OU1308;
IUPAC/Chemical Name
methyl 7-((1R,2R,3R)-3-hydroxy-2-((3S,5S,E)-3-hydroxy-5-methylnon-1-en-1-yl)-5-oxocyclopentyl)-6-oxoheptanoate
InChi Key
BBRBUTFBTUFFBU-LHACABTQSA-N
InChi Code
InChI=1S/C23H38O6/c1-4-5-8-16(2)13-18(25)11-12-19-20(22(27)15-21(19)26)14-17(24)9-6-7-10-23(28)29-3/h11-12,16,18-21,25-26H,4-10,13-15H2,1-3H3/b12-11+/t16-,18+,19+,20+,21+/m0/s1
SMILES Code
O=C(OC)CCCCC(C[C@@H]1[C@@H](/C=C/[C@@H](O)C[C@@H](C)CCCC)[C@H](O)CC1=O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 410.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Fujiyama N, Shitara Y, Horie T. The mechanism of the down-regulation of hepatic transporters in rats with indomethacin-induced intestinal injury. Dig Dis Sci. 2013 Jul;58(7):1891-8. doi: 10.1007/s10620-013-2587-z. Epub 2013 Feb 27. PubMed PMID: 23443493. 2: Nagase K, Hiwatashi N, Ito K, Maekawa H, Noguchi M, Kinouchi Y, Toyota T. [Effects of NSAIDs and PGE1 analogue on the permeability of human small intestine]. Nihon Shokakibyo Gakkai Zasshi. 1997 Jul;94(7):469-74. Japanese. PubMed PMID: 9277110. 3: Arakawa T, Watanabe T, Fukuda T, Higuchi K, Takaishi O, Yamasaki K, Kobayashi K, Tarnawski A. Indomethacin treatment during initial period of acetic acid-induced rat gastric ulcer healing promotes persistent polymorphonuclear cell-infiltration and increases future ulcer recurrence. Possible mediation of prostaglandins. Dig Dis Sci. 1996 Oct;41(10):2055-61. PubMed PMID: 8888721. 4: Matsuhashi N, Yamada A, Hiraishi M, Konishi T, Minota S, Saito T, Sugano K, Yazaki Y, Mori M, Shiga J. Multiple strictures of the small intestine after long-term nonsteroidal anti-inflammatory drug therapy. Am J Gastroenterol. 1992 Sep;87(9):1183-6. PubMed PMID: 1519577. 5: Tsuboshima M, Matsumoto K, Arai Y, Wakatsuka H, Kawasaki A. [Prostaglandins: synthetic and pharmacological studies and development]. Yakugaku Zasshi. 1992 Jul;112(7):447-69. Review. Japanese. PubMed PMID: 1432596. 6: Nakamura A, Yamatani T, Fujita T, Chiba T. Mechanism of inhibitory action of prostaglandins on the growth of human gastric carcinoma cell line KATO III. Gastroenterology. 1991 Oct;101(4):910-8. PubMed PMID: 1653751. 7: Okano H, Saeki S, Inui A, Kawai Y, Morimoto S, Ohmoto A, Nakashima T, Miyamoto M, Oh T, Takata A, et al. Effect of synthetic prostaglandin E1 analog (ornoprostil) on gastric emptying and pancreatic polypeptide release after solid-meal ingestion in man. Dig Dis Sci. 1991 Jan;36(1):47-51. PubMed PMID: 1985004. 8: Kobayashi K, Arakawa T, Higuchi K, Nakamura H. Gastric cytoprotection by ornoprostil, a PGE1 analogue, in human subjects. J Clin Gastroenterol. 1991;13 Suppl 1:S32-6. PubMed PMID: 1940194. 9: Tsukada H, Seino Y, Jo I, Tatsuta H, Ito K, Hashimoto A, Kotera T, Matsubayashi Y, Mori Y, Ito A, et al. [Prevention of alcohol-induced gastric mucosal injury by prostaglandin E-1]. Nihon Shokakibyo Gakkai Zasshi. 1990 Oct;87(10):2342-51. Japanese. PubMed PMID: 2250376. 10: Okabe S, Takeuchi K, Niida H, Takinami Y. Effects of TY-10957, a stable PGI2 derivative, on gastroduodenal lesions and secretory responses in the rat. Digestion. 1990;45(2):61-71. PubMed PMID: 2112498. 11: Fukuda T, Arakawa T, Torii Y, Nebiki H, Nakamura H, Kobayashi K. Roles of endogenous leukotrienes and prostaglandins in the healing of gastric ulcers induced by acetic acid in rats. Scand J Gastroenterol Suppl. 1989;162:2-5. PubMed PMID: 2556789.

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NSC-80467

NSC-80467