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MedKoo Cat#: 598694 | Name: Pleurosine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pleurosine is a catharanthuseus alkaloid.

Chemical Structure

Pleurosine
Pleurosine
CAS#39608-80-5

Theoretical Analysis

MedKoo Cat#: 598694

Name: Pleurosine

CAS#: 39608-80-5

Chemical Formula: C46H56N4O10

Exact Mass: 824.3996

Molecular Weight: 824.97

Elemental Analysis: C, 66.97; H, 6.84; N, 6.79; O, 19.39

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Pleurosine;
IUPAC/Chemical Name
(1aS,11S,13R,13aR)-11-acetoxy-11-((3aR,3a1R,4R,5S)-4-acetoxy-3a-ethyl-5-hydroxy-8-methoxy-5-(methoxycarbonyl)-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazol-9-yl)-1a-ethyl-1a,4,5,10,11,12,13,13a-octahydro-3,13-methanooxireno[2',3':9,10][1]azacycloundecino[5,4-b]indole 3(2H)-oxide
InChi Key
ATTVIAQTRLLYAD-LZCVXYBXSA-N
InChi Code
1S/C46H56N4O10/c1-8-42-16-12-18-49-19-17-44(38(42)49)31-21-32(35(56-6)22-34(31)48(5)39(44)46(54,41(53)57-7)40(42)58-26(3)51)45(59-27(4)52)23-28-24-50(55,25-43(9-2)37(28)60-43)20-15-30-29-13-10-11-14-33(29)47-36(30)45/h10-14,16,21-22,28,37-40,47,54H,8-9,15,17-20,23-25H2,1-7H3/t28-,37-,38+,39?,40-,42-,43+,44?,45+,46+,50+/m1/s1
SMILES Code
CC[C@]12CN3(CCc4c([C@](c5c(OC)cc(N(C)C6C78CCN9[C@H]8[C@@]([C@@H](OC(C)=O)[C@]6(O)C(OC)=O)(CC)C=CC9)c7c5)(OC(C)=O)C[C@@H]([C@H]1O2)C3)[nH]c%10c4cccc%10)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 824.97 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: El-Sayed A, Handy GA, Cordell GA. Catharanthus alkaloids, XXXVIII. Confirming structural evidence and antineoplastic activity of the bisindole alkaloids leurosine-N'b-oxide (pleurosine), roseadine and vindolicine from Catharanthus roseus. J Nat Prod. 1983 Jul-Aug;46(4):517-27. PubMed PMID: 6631435. 2: Kulanthaivel P, Barbuch RJ, Davidson RS, Yi P, Rener GA, Mattiuz EL, Hadden CE, Goodwin LA, Ehlhardt WJ. Selective reduction of N-oxides to amines: application to drug metabolism. Drug Metab Dispos. 2004 Sep;32(9):966-72. PubMed PMID: 15319338.