MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 585075 | Name: Semax
Featured

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.

Chemical Structure

Semax
CAS#80714-61-0

Theoretical Analysis

MedKoo Cat#: 585075

Name: Semax

CAS#: 80714-61-0

Chemical Formula: C37H51N9O10S

Exact Mass: 813.3480

Molecular Weight: 813.93

Elemental Analysis: C, 54.60; H, 6.32; N, 15.49; O, 19.66; S, 3.94

Price and Availability

Size Price Availability Quantity
1mg USD 310.00
5mg USD 760.00
10mg USD 1,265.00
Bulk Inquiry
Buy Now
Add to Cart
Related CAS #
No Data
Synonym
Semax
IUPAC/Chemical Name
L-methionyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-prolylglycyl-L-proline
InChi Key
AFEHBIGDWIGTEH-AQRCPPRCSA-N
InChi Code
InChI=1S/C37H51N9O10S/c1-57-16-13-24(38)32(50)42-25(11-12-31(48)49)33(51)43-26(18-23-19-39-21-41-23)34(52)44-27(17-22-7-3-2-4-8-22)36(54)46-15-5-9-28(46)35(53)40-20-30(47)45-14-6-10-29(45)37(55)56/h2-4,7-8,19,21,24-29H,5-6,9-18,20,38H2,1H3,(H,39,41)(H,40,53)(H,42,50)(H,43,51)(H,44,52)(H,48,49)(H,55,56)/t24-,25-,26-,27-,28-,29-/m0/s1
SMILES Code
O=C(O)[C@H]1N(C(CNC([C@H]2N(C([C@H](CC3=CC=CC=C3)NC([C@H](CC4=CNC=N4)NC([C@H](CCC(O)=O)NC([C@H](CCSC)N)=O)=O)=O)=O)CCC2)=O)=O)CCC1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO and DMF
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
Semax is a synthetic peptide analog of adrenocorticotropic hormone (ACTH) that has neuroprotective, analgesic, and anxiolytic properties.
In vitro activity:
This study determined that the neuroprotective effect of Semax in ischemic stroke can be due to its capacity to protect neurons from damage caused by oxidative stress. In cultured rat pheochromocytoma cell after oxidative stress induced by short-term incubation with hydrogen peroxide, Semax dose-dependently reduced the number of cells damaged by oxidative stress. Reference: Bull Exp Biol Med. 2003 Mar;135(3):268-71. https://pubmed.ncbi.nlm.nih.gov/12802399/
In vivo activity:
This study investigated the molecular mechanisms of Semax in the treatment of impairment of cerebral blood circulation. The neuroprotective action of Semax may be associated with a compensation of mRNA expression patterns that are disrupted during ischaemia-reperfusion conditions. Following transient middle cerebral artery occlusion in rats, Semax suppressed the expression of genes related to inflammatory processes and activated the expression of genes related to neurotransmission. Reference: Genes (Basel). 2020 Jun 22;11(6):681. https://pubmed.ncbi.nlm.nih.gov/32580520/
Solvent mg/mL mM comments
Solubility
DMF 1.0 1.23
DMSO 5.0 6.14
Note: There can be variations in solubility for the same chemical from different vendors or different batches from the same vendor. The following factors can affect the solubility of the same chemical: solvent used for crystallization, residual solvent content, polymorphism, salt versus free form, degree of hydration, solvent temperature. Please use the solubility data as a reference only. Warming and sonication will facilitate dissolving. Still have questions? Please contact our Technical Support scientists.

Preparing Stock Solutions

The following data is based on the product molecular weight 813.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Kobylyanskii AG, Zolotarev YA, Andreeva LA, Grivennikov IA, Myasoedov NF. Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells. Bull Exp Biol Med. 2017 Oct;163(6):731-736. doi: 10.1007/s10517-017-3891-y. Epub 2017 Oct 24. PMID: 29063333. 2. Safarova ER, Shram SI, Zolotarev YA, Myasoedov NF. Effect of Semax peptide on survival of cultured rat pheochromocytoma cells during oxidative stress. Bull Exp Biol Med. 2003 Mar;135(3):268-71. doi: 10.1023/a:1024141232307. PMID: 12802399. 3. Svishcheva MV, Mukhina AY, Medvedeva OA, Shevchenko AV, Bobyntsev II, Kalutskii PV, Andreeva LA, Myasoedov NF. Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress. Bull Exp Biol Med. 2020 Jul;169(3):357-360. doi: 10.1007/s10517-020-04886-7. Epub 2020 Aug 1. PMID: 32737723. 4. Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Sudarkina OY, Dmitrieva VG, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV. Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats. Genes (Basel). 2020 Jun 22;11(6):681. doi: 10.3390/genes11060681. PMID: 32580520; PMCID: PMC7350263.
In vitro protocol:
1. Kobylyanskii AG, Zolotarev YA, Andreeva LA, Grivennikov IA, Myasoedov NF. Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells. Bull Exp Biol Med. 2017 Oct;163(6):731-736. doi: 10.1007/s10517-017-3891-y. Epub 2017 Oct 24. PMID: 29063333. 2. Safarova ER, Shram SI, Zolotarev YA, Myasoedov NF. Effect of Semax peptide on survival of cultured rat pheochromocytoma cells during oxidative stress. Bull Exp Biol Med. 2003 Mar;135(3):268-71. doi: 10.1023/a:1024141232307. PMID: 12802399.
In vivo protocol:
1. Svishcheva MV, Mukhina AY, Medvedeva OA, Shevchenko AV, Bobyntsev II, Kalutskii PV, Andreeva LA, Myasoedov NF. Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress. Bull Exp Biol Med. 2020 Jul;169(3):357-360. doi: 10.1007/s10517-020-04886-7. Epub 2020 Aug 1. PMID: 32737723. 2. Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Sudarkina OY, Dmitrieva VG, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV. Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats. Genes (Basel). 2020 Jun 22;11(6):681. doi: 10.3390/genes11060681. PMID: 32580520; PMCID: PMC7350263.
1: Filippenkov IB, Remizova JA, Stavchansky VV, Denisova AE, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV. Synthetic Adrenocorticotropic Peptides Modulate the Expression Pattern of Immune Genes in Rat Brain following the Early Post-Stroke Period. Genes (Basel). 2023 Jun 30;14(7):1382. doi: 10.3390/genes14071382. PMID: 37510287; PMCID: PMC10379992. 2: Vyunova TV, Andreeva LA, Shevchenko KV, Glazova NY, Sebentsova EA, Levitskaya NG, Myasoedov NF. Synthetic corticotropins and the GABA-receptor system: Direct and delayed effects. Chem Biol Drug Des. 2023 Jun;101(6):1393-1405. doi: 10.1111/cbdd.14221. Epub 2023 Mar 6. PMID: 36828803. 3: Stavchansky VV, Filippenkov IB, Remizova JA, Denisova AE, Mozgovoy IV, Gubsky LV, Myasoedov NF, Andreeva LA, Limborska SA, Dergunova LV. Insight into Glyproline Peptides' Activity through the Modulation of the Inflammatory and Neurosignaling Genetic Response Following Cerebral Ischemia-Reperfusion. Genes (Basel). 2022 Dec 16;13(12):2380. doi: 10.3390/genes13122380. PMID: 36553646; PMCID: PMC9777888. 4: Dragon AK, Korchazhkina NB, Sheludchenko VM, Yusef Y, Kosova JV, Makarova MA, Elfimov MA. Rezul'taty primeneniya kompleksnoi fizioterapevticheskoi neirostimulyatsii pri opticheskikh neiropatiyakh sosudistogo geneza [Results of the application of complex physiotherapeutic neurostimulation in optical neuropathies of various genesis]. Vopr Kurortol Fizioter Lech Fiz Kult. 2022;99(4. Vyp. 2):72-77. Russian. doi: 10.17116/kurort20229904272. PMID: 36083821. 5: Hu Z, Lu M, Wang X, Yang W, Fan Y, Li T, Wang L, Wei T. Diagnostic Value of Different 3-D Shear Wave Elastography Sections in the Diagnosis of Thyroid Nodules. Ultrasound Med Biol. 2022 Sep;48(9):1957-1965. doi: 10.1016/j.ultrasmedbio.2022.05.036. Epub 2022 Jul 16. PMID: 35853762. 6: Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13(4):486-496. doi: 10.1021/acschemneuro.1c00707. Epub 2022 Jan 26. PMID: 35080861; PMCID: PMC8855339. 7: Kolacheva AA, Ugrumov MV. A Mouse Model of Nigrostriatal Dopaminergic Axonal Degeneration As a Tool for Testing Neuroprotectors. Acta Naturae. 2021 Jul- Sep;13(3):110-113. doi: 10.32607/actanaturae.11433. PMID: 34707903; PMCID: PMC8526182. 8: Filippenkov IB, Stavchansky VV, Glazova NY, Sebentsova EA, Remizova JA, Valieva LV, Levitskaya NG, Myasoedov NF, Limborska SA, Dergunova LV. Antistress Action of Melanocortin Derivatives Associated with Correction of Gene Expression Patterns in the Hippocampus of Male Rats Following Acute Stress. Int J Mol Sci. 2021 Sep 17;22(18):10054. doi: 10.3390/ijms221810054. PMID: 34576218; PMCID: PMC8469576. 9: Student IOHP, Professor SYSMPD. Investigation of the effect of a modified fragment of neuropeptide Y on memory phases and extrapolation escape of animals. Ceska Slov Farm. 2021 Summer;70(3):93-101. English. PMID: 34418946. 10: Sudarkina OY, Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Valieva LV, Remizova JA, Dmitrieva VG, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV. Brain Protein Expression Profile Confirms the Protective Effect of the ACTH(4-7)PGP Peptide (Semax) in a Rat Model of Cerebral Ischemia-Reperfusion. Int J Mol Sci. 2021 Jun 8;22(12):6179. doi: 10.3390/ijms22126179. PMID: 34201112; PMCID: PMC8226508. 11: Dergunova LV, Dmitrieva VG, Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Valieva LV, Sudarkina OY, Gubsky LV, Myasoedov NF, Limborska SA. [The Peptide Drug ACTH(4-7)PGP (Semax) Suppresses mRNA Transcripts Encoding Proinflammatory Mediators Induced by Reversible Ischemia of the Rat Brain]. Mol Biol (Mosk). 2021 May-Jun;55(3):402-411. Russian. doi: 10.31857/S0026898421010043. PMID: 34097675. 12: Shakova FM, Kirova YI, Silachev DN, Romanova GA, Morozov SG. Protective Effects of PGC-1α Activators on Ischemic Stroke in a Rat Model of Photochemically Induced Thrombosis. Brain Sci. 2021 Mar 4;11(3):325. doi: 10.3390/brainsci11030325. PMID: 33806692; PMCID: PMC8002020. 13: Svishcheva MV, Mishina YS, Medvedeva OA, Bobyntsev II, Mukhina AY, Kalutskii PV, Andreeva LA, Myasoedov NF. Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax). Bull Exp Biol Med. 2021 Jan;170(3):384-388. doi: 10.1007/s10517-021-05072-z. Epub 2021 Jan 18. PMID: 33459919. 14: Glazova NY, Manchenko DM, Volodina MA, Merchieva SA, Andreeva LA, Kudrin VS, Myasoedov NF, Levitskaya NG. Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats. Neuropeptides. 2021 Apr;86:102114. doi: 10.1016/j.npep.2020.102114. Epub 2020 Dec 28. PMID: 33418449. 15: Severyanova LA, Kryukov AA, Plotnikov DV, Dolgintsev ME. Peptide ACTH4-7-PGP: Effects on Various Types of Pain and Pain-Induced Behavior in Rats after Systemic and Central Administration. Bull Exp Biol Med. 2020 Dec;170(2):185-190. doi: 10.1007/s10517-020-05029-8. Epub 2020 Dec 2. PMID: 33263853. 16: Svishcheva MV, Mukhina AY, Medvedeva OA, Shevchenko AV, Bobyntsev II, Kalutskii PV, Andreeva LA, Myasoedov NF. Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress. Bull Exp Biol Med. 2020 Jul;169(3):357-360. doi: 10.1007/s10517-020-04886-7. Epub 2020 Aug 1. PMID: 32737723. 17: Leonidovna YA, Aleksandrovna SM, Aleksandrovna TA, Aleksandrovna BO, Fedorovich MN, Aleksandrovna AL. The Influence of Selank on the Level of Cytokines Under the Conditions of "Social" Stress. Curr Rev Clin Exp Pharmacol. 2021;16(2):162-167. doi: 10.2174/1574884715666200704152810. PMID: 32621722. 18: Filippenkov IB, Stavchansky VV, Denisova AE, Yuzhakov VV, Sevan'kaeva LE, Sudarkina OY, Dmitrieva VG, Gubsky LV, Myasoedov NF, Limborska SA, Dergunova LV. Novel Insights into the Protective Properties of ACTH(4-7)PGP (Semax) Peptide at the Transcriptome Level Following Cerebral Ischaemia-Reperfusion in Rats. Genes (Basel). 2020 Jun 22;11(6):681. doi: 10.3390/genes11060681. PMID: 32580520; PMCID: PMC7350263. 19: Panikratova YR, Lebedeva IS, Sokolov OY, Rumshiskaya AD, Kupriyanov DA, Kost NV, Myasoedov NF. Functional Connectomic Approach to Studying Selank and Semax Effects. Dokl Biol Sci. 2020 Jan;490(1):9-11. doi: 10.1134/S001249662001007X. Epub 2020 Apr 27. PMID: 32342318. 20: Elagina AA, Lyashev YD, Lyashev AY, Pronyaeva TV, Chahine AR. Correction of Lipid Metabolism Disorders in Diabetes Mellitus with Peptide Drugs. Bull Exp Biol Med. 2020 Mar;168(5):618-620. doi: 10.1007/s10517-020-04764-2. Epub 2020 Apr 4. PMID: 32246363.

View History

Levetimide

Levetimide

Levetimide HCl

Levetimide HCl

Levemopamil HCl

Levemopamil HCl