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MedKoo Cat#: 592653 | Name: Esterbut-3

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Esterbut-3 stabilizes butyric acid as a potent inhibitor of tumor cell proliferation in vivo.

Chemical Structure

Esterbut-3
Esterbut-3
CAS#125161-47-9

Theoretical Analysis

MedKoo Cat#: 592653

Name: Esterbut-3

CAS#: 125161-47-9

Chemical Formula: C13H22O7

Exact Mass: 290.1366

Molecular Weight: 290.31

Elemental Analysis: C, 53.78; H, 7.64; O, 38.58

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Esterbut-3
IUPAC/Chemical Name
alpha-D-Glucofuranose, 1,2-O-(1-methylethylidene)-, 3-butanoate
InChi Key
WFVFQUPBGWFLMB-DVYMNCLGSA-N
InChi Code
InChI=1S/C13H22O7/c1-4-5-8(16)17-10-9(7(15)6-14)18-12-11(10)19-13(2,3)20-12/h7,9-12,14-15H,4-6H2,1-3H3/t7-,9-,10+,11-,12-/m1/s1
SMILES Code
O[C@H](CO)[C@@H](O1)[C@H](OC(CCC)=O)[C@@H](O2)[C@H]1OC2(C)C
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 290.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Planchon P, Magnien V, Beaupain R, Mainguene C, Ronco G, Villa P, Brouty-Boye D. Differential effects of butyrate derivatives on human breast cancer cells grown as organotypic nodules in vitro and as xenografts in vivo. In Vivo. 1992 Nov-Dec;6(6):605-10. PubMed PMID: 1296809. 2: Planchon P, Magnien V, Starzec A, Prevost G. Selection of a highly tumorigenic breast cancer cell line sensitive to estradiol to evidence in vivo the tumor-inhibitory effect of butyrate derivative Monobut-3. Life Sci. 1994;55(12):951-9. PubMed PMID: 8057757. 3: Planchon P, Magnien V, Ronco G, Villa P, Brouty-Boye D. Morphology and intermediate filament composition of human mammary epithelial cells treated with stable butyrate derivative. Anticancer Res. 1992 Nov-Dec;12(6B):2315-20. PubMed PMID: 1284203. 4: Pouillart P, Cerutti I, Ronco G, Villa P, Chany C. Enhancement by stable butyrate derivatives of antitumor and antiviral actions of interferon. Int J Cancer. 1992 Jun 19;51(4):596-601. PubMed PMID: 1318271. 5: Calabresse C, Venturini L, Ronco G, Villa P, Degos L, Belpomme D, Chomienne C. Selective induction of apoptosis in myeloid leukemic cell lines by monoacetone glucose-3 butyrate. Biochem Biophys Res Commun. 1994 May 30;201(1):266-83. PubMed PMID: 8198584. 6: Calabresse C, Venturini L, Ronco G, Villa P, Chomienne C, Belpomme D. Butyric acid and its monosaccharide ester induce apoptosis in the HL-60 cell line. Biochem Biophys Res Commun. 1993 Aug 31;195(1):31-8. PubMed PMID: 8363611. 7: Bras-Gonçalves RA, Pocard M, Formento JL, Poirson-Bichat F, De Pinieux G, Pandrea I, Arvelo F, Ronco G, Villa P, Coquelle A, Milano G, Lesuffleur T, Dutrillaux B, Poupon MF. Synergistic efficacy of 3n-butyrate and 5-fluorouracil in human colorectal cancer xenografts via modulation of DNA synthesis. Gastroenterology. 2001 Mar;120(4):874-88. PubMed PMID: 11231942. 8: Planchon P, Raux H, Magnien V, Ronco G, Villa P, Crépin M, Brouty-Boyé D. New stable butyrate derivatives alter proliferation and differentiation in human mammary cells. Int J Cancer. 1991 May 30;48(3):443-9. PubMed PMID: 2040538. 9: Pouillart P, Cerutti I, Ronco G, Villa P, Chany C. [Protective activity of monoacetone glucose 3-butyrate, prodrug of n-butyric acid, against the fatal effect of encephalomyocarditis virus in mice]. C R Acad Sci III. 1992;314(2):49-54. French. PubMed PMID: 1313734. 10: Pouillart P, Cerutti I, Ronco G, Villa P, Chany C. Butyric monosaccharide ester-induced cell differentiation and anti-tumor activity in mice. Importance of their prolonged biological effect for clinical applications in cancer therapy. Int J Cancer. 1991 Aug 19;49(1):89-95. PubMed PMID: 1874576.