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MedKoo Cat#: 592647 | Name: Acemannan

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway.

Chemical Structure

Acemannan
Acemannan
CAS#115426-79-4 (free base)

Theoretical Analysis

MedKoo Cat#: 592647

Name: Acemannan

CAS#: 115426-79-4 (free base)

Chemical Formula: C66H100NO49-

Exact Mass: 1690.5369

Molecular Weight: 1691.48

Elemental Analysis: C, 46.87; H, 5.96; N, 0.83; O, 46.35

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
115426-79-4 (free base) 110042-95-0 (acetate)
Synonym
Acemannan; Acemannanan
IUPAC/Chemical Name
alpha-D-Galacto-beta-D-mannan, (1-4),(1-6)-, acetate
InChi Key
XOYXESIZZFUVRD-UVSAJTFZSA-M
InChi Code
InChI=1S/C66H101NO49/c1-18(75)67-33-34(83)42(26(11-68)102-59(33)110-44-29(14-71)106-63(38(87)51(44)97-21(4)78)113-46-30(15-72)107-64(39(88)53(46)99-23(6)80)111-45-28(13-70)103-60(94-10)35(84)50(45)96-20(3)77)109-61-37(86)52(98-22(5)79)48(32(17-74)105-61)114-66-41(90)55(101-25(8)82)56(57(116-66)58(91)92)115-65-40(89)54(100-24(7)81)47(31(16-73)108-65)112-62-36(85)49(95-19(2)76)43(93-9)27(12-69)104-62/h26-57,59-66,68-74,83-90H,11-17H2,1-10H3,(H,67,75)(H,91,92)/p-1/t26-,27-,28-,29-,30-,31-,32-,33+,34-,35+,36+,37+,38+,39+,40+,41+,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56+,57+,59-,60+,61-,62-,63-,64-,65-,66+/m1/s1
SMILES Code
CO[C@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@H]([C@H](OC(C)=O)[C@@H]2O)O[C@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@H](CO)[C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@H]6O[C@H](C([O-])=O)[C@@H](O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](OC)[C@H](OC(C)=O)[C@@H]8O)[C@H](OC(C)=O)[C@@H]7O)[C@H](OC(C)=O)[C@@H]6O)[C@H](OC(C)=O)[C@@H]5O)[C@H](O)[C@@H]4NC(C)=O)[C@H](OC(C)=O)[C@@H]3O)[C@H](OC(C)=O)[C@@H]1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 1,691.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Sierra-García GD, Castro-Ríos R, González-Horta A, Lara-Arias J, Chávez-Montes A. Acemannan, an extracted polysaccharide from Aloe vera: A literature review. Nat Prod Commun. 2014 Aug;9(8):1217-21. Review. PubMed PMID: 25233608. 2: Xing W, Guo W, Zou CH, Fu TT, Li XY, Zhu M, Qi JH, Song J, Dong CH, Li Z, Xiao Y, Yuan PS, Huang H, Xu X. Acemannan accelerates cell proliferation and skin wound healing through AKT/mTOR signaling pathway. J Dermatol Sci. 2015 Aug;79(2):101-9. doi: 10.1016/j.jdermsci.2015.03.016. Epub 2015 Apr 1. PubMed PMID: 26049685. 3: Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. J Altern Complement Med. 2013 May;19(5):429-34. doi: 10.1089/acm.2012.0164. Epub 2012 Dec 16. PubMed PMID: 23240939. 4: Chokboribal J, Tachaboonyakiat W, Sangvanich P, Ruangpornvisuti V, Jettanacheawchankit S, Thunyakitpisal P. Deacetylation affects the physical properties and bioactivity of acemannan, an extracted polysaccharide from Aloe vera. Carbohydr Polym. 2015 Nov 20;133:556-66. doi: 10.1016/j.carbpol.2015.07.039. Epub 2015 Jul 17. PubMed PMID: 26344314. 5: Chantarawaratit P, Sangvanich P, Banlunara W, Soontornvipart K, Thunyakitpisal P. Acemannan sponges stimulate alveolar bone, cementum and periodontal ligament regeneration in a canine class II furcation defect model. J Periodontal Res. 2014 Apr;49(2):164-78. doi: 10.1111/jre.12090. Epub 2013 May 28. PubMed PMID: 23710575. 6: Boonyagul S, Banlunara W, Sangvanich P, Thunyakitpisal P. Effect of acemannan, an extracted polysaccharide from Aloe vera, on BMSCs proliferation, differentiation, extracellular matrix synthesis, mineralization, and bone formation in a tooth extraction model. Odontology. 2014 Jul;102(2):310-7. doi: 10.1007/s10266-012-0101-2. Epub 2013 Jan 12. PubMed PMID: 23315202. 7: Escobedo-Lozano AY, Domard A, Velázquez CA, Goycoolea FM, Argüelles-Monal WM. Physical properties and antibacterial activity of chitosan/acemannan mixed systems. Carbohydr Polym. 2015 Jan 22;115:707-14. doi: 10.1016/j.carbpol.2014.07.064. Epub 2014 Aug 7. PubMed PMID: 25439952. 8: Songsiripradubboon S, Banlunara W, Sangvanich P, Trairatvorakul C, Thunyakitpisal P. Clinical, radiographic, and histologic analysis of the effects of acemannan used in direct pulp capping of human primary teeth: short-term outcomes. Odontology. 2016 Sep;104(3):329-37. doi: 10.1007/s10266-015-0215-4. Epub 2015 Aug 12. PubMed PMID: 26264630. 9: Jittapiromsak N, Sahawat D, Banlunara W, Sangvanich P, Thunyakitpisal P. Acemannan, an extracted product from Aloe vera, stimulates dental pulp cell proliferation, differentiation, mineralization, and dentin formation. Tissue Eng Part A. 2010 Jun;16(6):1997-2006. doi: 10.1089/ten.TEA.2009.0593. PubMed PMID: 20088703. 10: Womble D, Helderman JH. The impact of acemannan on the generation and function of cytotoxic T-lymphocytes. Immunopharmacol Immunotoxicol. 1992;14(1-2):63-77. PubMed PMID: 1597661. 11: Zhang L, Tizard IR. Activation of a mouse macrophage cell line by acemannan: the major carbohydrate fraction from Aloe vera gel. Immunopharmacology. 1996 Nov;35(2):119-28. PubMed PMID: 8956975. 12: Ramamoorthy L, Tizard IR. Induction of apoptosis in a macrophage cell line RAW 264.7 by acemannan, a beta-(1,4)-acetylated mannan. Mol Pharmacol. 1998 Mar;53(3):415-21. PubMed PMID: 9495806. 13: Jettanacheawchankit S, Sasithanasate S, Sangvanich P, Banlunara W, Thunyakitpisal P. Acemannan stimulates gingival fibroblast proliferation; expressions of keratinocyte growth factor-1, vascular endothelial growth factor, and type I collagen; and wound healing. J Pharmacol Sci. 2009 Apr;109(4):525-31. PubMed PMID: 19372635. 14: Lee JK, Lee MK, Yun YP, Kim Y, Kim JS, Kim YS, Kim K, Han SS, Lee CK. Acemannan purified from Aloe vera induces phenotypic and functional maturation of immature dendritic cells. Int Immunopharmacol. 2001 Jul;1(7):1275-84. PubMed PMID: 11460308. 15: Womble D, Helderman JH. Enhancement of allo-responsiveness of human lymphocytes by acemannan (Carrisyn). Int J Immunopharmacol. 1988;10(8):967-74. PubMed PMID: 2975271. 16: Stuart RW, Lefkowitz DL, Lincoln JA, Howard K, Gelderman MP, Lefkowitz SS. Upregulation of phagocytosis and candidicidal activity of macrophages exposed to the immunostimulant acemannan. Int J Immunopharmacol. 1997 Feb;19(2):75-82. PubMed PMID: 9278177. 17: King GK, Yates KM, Greenlee PG, Pierce KR, Ford CR, McAnalley BH, Tizard IR. The effect of Acemannan Immunostimulant in combination with surgery and radiation therapy on spontaneous canine and feline fibrosarcomas. J Am Anim Hosp Assoc. 1995 Sep-Oct;31(5):439-47. PubMed PMID: 8542364. 18: Montaner JS, Gill J, Singer J, Raboud J, Arseneau R, McLean BD, Schechter MT, Ruedy J. Double-blind placebo-controlled pilot trial of acemannan in advanced human immunodeficiency virus disease. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Jun 1;12(2):153-7. PubMed PMID: 8680886. 19: Yates KM, Rosenberg LJ, Harris CK, Bronstad DC, King GK, Biehle GA, Walker B, Ford CR, Hall JE, Tizard IR. Pilot study of the effect of acemannan in cats infected with feline immunodeficiency virus. Vet Immunol Immunopathol. 1992 Dec;35(1-2):177-89. PubMed PMID: 1337396. 20: Fogleman RW, Chapdelaine JM, Carpenter RH, McAnalley BH. Toxicologic evaluation of injectable acemannan in the mouse, rat and dog. Vet Hum Toxicol. 1992 Jun;34(3):201-5. PubMed PMID: 1609484.

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