MedKoo Cat#: 461345 | Name: Risotilide

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Risotilide is an inhibitor of the voltage-dependent potassium channel known to prolong cardiac action potentials and refractory periods.

Chemical Structure

Risotilide
Risotilide
CAS#120688-08-6

Theoretical Analysis

MedKoo Cat#: 461345

Name: Risotilide

CAS#: 120688-08-6

Chemical Formula: C15H27N3O4S2

Exact Mass: 377.1443

Molecular Weight: 377.51

Elemental Analysis: C, 47.72; H, 7.21; N, 11.13; O, 16.95; S, 16.98

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Synonym
Risotilide;
IUPAC/Chemical Name
N-isopropyl-N-(2-(isopropylamino)ethyl)-4-(methylsulfonamido)benzenesulfonamide
InChi Key
GLIRXHQYWRYQDV-UHFFFAOYSA-N
InChi Code
InChI=1S/C15H27N3O4S2/c1-12(2)16-10-11-18(13(3)4)24(21,22)15-8-6-14(7-9-15)17-23(5,19)20/h6-9,12-13,16-17H,10-11H2,1-5H3
SMILES Code
O=S(C1=CC=C(NS(=O)(C)=O)C=C1)(N(C(C)C)CCNC(C)C)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 377.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Hewett KW, Le FK, Martin KL, Brasington CR, Piecuch S, Case CL. Changes in atrioventricular conduction properties with refractory-period modulation. J Cardiovasc Pharmacol. 1996 Dec;28(6):824-32. PubMed PMID: 8961081. 2: McLarnon JG, Wang XP. Actions of cardiac drugs on a calcium-dependent potassium channel in hippocampal neurons. Mol Pharmacol. 1991 Apr;39(4):540-6. PubMed PMID: 2017153. 3: Kowey PR, Friechling TD, Sewter J, Wu Y, Sokil A, Paul J, Nocella J. Electrophysiological effects of left ventricular hypertrophy. Effect of calcium and potassium channel blockade. Circulation. 1991 Jun;83(6):2067-75. PubMed PMID: 1645624. 4: Burckhardt BC, Gögelein H. Small and maxi K+ channels in the basolateral membrane of isolated crypts from rat distal colon: single-channel and slow whole-cell recordings. Pflugers Arch. 1992 Jan;420(1):54-60. PubMed PMID: 1553263. 5: Tizón-Marcos H, Bertrand OF, Rodés-Cabau J, Larose E, Gaudreault V, Bagur R, Gleeton O, Courtis J, Roy L, Poirier P, Costerousse O, De Larochellière R. Impact of female gender and transradial coronary stenting with maximal antiplatelet therapy on bleeding and ischemic outcomes. Am Heart J. 2009 Apr;157(4):740-5. doi: 10.1016/j.ahj.2008.12.003. Epub 2009 Jan 31. PubMed PMID: 19332204. 6: Wu KM, Hunter TL, Proakis AG. A dual electrophysiologic test for atrial antireentry and ventricular antifibrillatory studies. Effects of bethanidine, procainamide, and WY-48986. J Pharmacol Methods. 1990 Apr;23(2):87-95. PubMed PMID: 2332983. 7: Rodríguez-Díaz JL, Rosas-Camargo V, Vega-Vega O, Morales-Espinosa D, Mendez-Reguera A, Martínez-Tlahuel JL, Gamboa-Domínguez A, Arrieta O. Clinical and pathological factors associated with the development of hepatocellular carcinoma in patients with hepatitis virus-related cirrhosis: a long-term follow-up study. Clin Oncol (R Coll Radiol). 2007 Apr;19(3):197-203. Epub 2007 Jan 18. PubMed PMID: 17359907. 8: Clay JR, Kristof AS, Shenasa J, Brochu RM, Shrier A. A review of the effects of three cardioactive agents on the electrical activity from embryonic chick heart cell aggregates: TTX, ACh, and E-4031. Prog Biophys Mol Biol. 1994;62(3):185-202. Review. PubMed PMID: 7892502.