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MedKoo Cat#: 573353 | Name: Pelrinone hydrochloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Pelrinone hydrochloride is a phosphodiesterase (PDE) inhibitor with antithrombotic activities. Pelrinone hydrochloride has been shown to be a deterrant of platelet aggregation and white thrombus formation.

Chemical Structure

Pelrinone hydrochloride
Pelrinone hydrochloride
CAS#89232-84-8 (HCl)

Theoretical Analysis

MedKoo Cat#: 573353

Name: Pelrinone hydrochloride

CAS#: 89232-84-8 (HCl)

Chemical Formula: C12H12ClN5O

Exact Mass: 277.0730

Molecular Weight: 277.71

Elemental Analysis: C, 51.90; H, 4.36; Cl, 12.77; N, 25.22; O, 5.76

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
94386-65-9 (free base); 89232-84-8 (HCl)
Synonym
Pelrinone hydrochloride
IUPAC/Chemical Name
5-Pyrimidinecarbonitrile, 1,4-dihydro-2-methyl-4-oxo-6-((3-pyridinylmethyl)amino)-, monohydrochloride
InChi Key
AVVVYDOYYJBULZ-UHFFFAOYSA-N
InChi Code
1S/C12H11N5O.ClH/c1-8-16-11(10(5-13)12(18)17-8)15-7-9-3-2-4-14-6-9;/h2-4,6H,7H2,1H3,(H2,15,16,17,18);1H
SMILES Code
c1(c(c(nc([nH]1)C)=O)C#N)NCc1cccnc1.Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 277.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Kitzen JM, McCallum JD, Harvey C, Morin ME. Antithrombotic activity of the phosphodiesterase III inhibitor pelrinone in a canine model of coronary artery thrombosis: enhancement of efficacy with concurrent alpha 2-adrenergic antagonism. J Cardiovasc Pharmacol. 1991 Dec;18(6):777-90. PubMed PMID: 1725888. 2: Patelunas DM, Carmint WJ, Willis JZ, Colatsky TJ, Fenichel RL. Comparative antithrombotic activities of the phosphodiesterase inhibitors pelrinone (AY-26,768), AY-31,390 and milrinone. Thromb Res. 1991 Jun 1;62(5):389-400. PubMed PMID: 1896959. 3: Scatina JA, Hicks DR, Kraml M, Cayen MN. Metabolic disposition and pharmacokinetics of pelrinone, a new cardiotonic drug, in laboratory animals and man. Eur J Drug Metab Pharmacokinet. 1990 Jan-Mar;15(1):37-48. PubMed PMID: 2384116.