Synonym
Rifametane; Rifametanum;
IUPAC/Chemical Name
A name could not be generated for this structure.
InChi Key
MPNLXDYNHVIMAT-CDBKKNIDSA-N
InChi Code
InChI=1S/C44H60N4O12/c1-13-48(14-2)27(9)47-45-20-29-34-39(54)32-31(38(29)53)33-41(26(8)37(32)52)60-44(11,42(33)55)58-19-18-30(57-12)23(5)40(59-28(10)49)25(7)36(51)24(6)35(50)21(3)16-15-17-22(4)43(56)46-34/h15-21,23-25,30,35-36,40,50-54H,13-14H2,1-12H3,(H,46,56)/b16-15+,19-18+,22-17-,45-20+,47-27+/t21-,23-,24+,25-,30-,35-,36+,40+,44-/m0/s1
SMILES Code
CCN(/C(C)=N/N=C/c1c(O)c2c3c(O[C@@](O/C=C/[C@H](OC)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)/C=C/C=C4/C)(C)C3=O)c(C)c(O)c2c(O)c1NC4=O)CC
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
836.98
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Bruzzese T, Rimaroli C, Bonabello A, Mozzi G, Ajay S, Cooverj ND. Pharmacokinetics and tissue distribution of rifametane, a new 3-azinomethyl-rifamycin derivative, in several animal species. Arzneimittelforschung. 2000 Jan;50(1):60-71. PubMed PMID: 10683718.
2: Potkar C, Gogtay N, Gokhale P, Kshirsagar NA, Ajay S, Cooverji ND, Bruzzese T. Phase I pharmacokinetic study of a new 3-azinomethyl-rifamycin (rifametane) as compared to rifampicin. Chemotherapy. 1999 May-Jun;45(3):147-53. PubMed PMID: 10224335.
3: Kelkar MS, Saraf AP, Bakhle DS, Nazare V, Ajay S, Hegde S, Lal HM, Cooverji ND, Bruzzese T. Pharmacokinetic profile of a new 3-azinomethyl rifamycin (SPA-S-565) in volunteers as compared with conventional rifampicin. Int J Clin Pharmacol Res. 1998;18(3):137-43. PubMed PMID: 9825270.
