Eclazolast | CAS#80263-73-6 | antiallergic

MedKoo Cat#: 461298 | Name: Eclazolast

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Eclazolast is a lipophilic antiallergic drug.

Chemical Structure

Eclazolast

CAS#80263-73-6

Theoretical Analysis

MedKoo Cat#: 461298

Name: Eclazolast

CAS#: 80263-73-6

Chemical Formula: C12H12ClNO4

Exact Mass: 269.0455

Molecular Weight: 269.68

Elemental Analysis: C, 53.45; H, 4.49; Cl, 13.15; N, 5.19; O, 23.73

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

Bulk Inquiry

Related CAS #

No Data

Synonym

Eclazolast; RHC 2871; RHC-2871; RHC2871; REV 2871; REV2871; REV-2871.

IUPAC/Chemical Name

2-ethoxyethyl 5-chlorobenzo[d]oxazole-2-carboxylate

InChi Key

HNJUBRBHULQQFX-UHFFFAOYSA-N

InChi Code

InChI=1S/C12H12ClNO4/c1-2-16-5-6-17-12(15)11-14-9-7-8(13)3-4-10(9)18-11/h3-4,7H,2,5-6H2,1H3

SMILES Code

O=C(C1=NC2=CC(Cl)=CC=C2O1)OCCOCC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 269.68 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Fischer MJ, de Mol NJ. Mechanism of action of the nonlipophilic antiallergic drug eclazolast (REV 2871) in the inhibition of mediator release in a mast cell model. Inflamm Res. 1999 Nov;48(11):569-74. PubMed PMID: 10598012. 2: Coutts SM, Khandwala A, Weinryb I. REV 2871 (CHBZ): a potent antiallergic agent with a novel mechanism of action. II. Studies on the mechanism of action. Biochem Pharmacol. 1987 Mar 1;36(5):673-82. PubMed PMID: 2881546. 3: Khandwala A, Coutts S, Pruss T, Jones H, Neiss E, Weinryb I. REV 2871 (CHBZ): a potent antiallergic agent with a novel mechanism of action. I. Activity profile as an inhibitor of mediator release. Biochem Pharmacol. 1987 Mar 1;36(5):663-72. PubMed PMID: 2435293. 4: Coutts SM, Khandwala A, Shoupe TS, Musser JH, Klunk LJ, Weinryb I. REV 2871 (CHBZ): a novel inhibitor of histamine release. Agents Actions. 1986 Jun;18(3-4):318-24. PubMed PMID: 2428220.