Synonym
Pyropheophorbide-a; pyrophaeophorbide a; pyrophaeophorbide-a; pyropheophorbide a;
InChi Key
JUDGRMABQJKRPW-XJOBVBABSA-N
InChi Code
InChI=1S/C33H34N4O3/c1-7-19-15(3)23-12-25-17(5)21(9-10-30(39)40)32(36-25)22-11-29(38)31-18(6)26(37-33(22)31)14-28-20(8-2)16(4)24(35-28)13-27(19)34-23/h7,12-14,17,21,35-36H,1,8-11H2,2-6H3,(H,39,40)/b25-12-,26-14-,27-13-,32-22-/t17-,21?/m0/s1
Appearance
To be determined
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 -4 C for short term (days to weeks) or -20 C for long term(months to years).
Solubility
To be determined
Shelf Life
>2 years if stored properly
Drug Formulation
To be determined
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
534.66
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1.) Xodo, et al. The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy. Current Medicinal Chemistry, Volume 19, Number 6, 2012, pp. 799-807(9)
2.) Saenz, et al. Structural and Epimeric Isomers of HPPH [3-Devinyl 3-{1-(1-hexyloxy) ethyl}pyropheophorbide-a]: Effects on Uptake and Photodynamic Therapy of Cancer. ACS Chem. Biol. 2017, 12, 4, 933–946. https://doi.org/10.1021/acschembio.7b00023
3.) Saide, et al. Pheophorbide a: State of the Art. Mar. Drugs 2020, 18(5), 257; https://doi.org/10.3390/md18050257
4.) Myrzakhmetov, et. al. Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a, and Photofrin® in Different Conditions. Pharmaceuticals 2021, 14(2), 138; https://doi.org/10.3390/ph14020138
5.) Breloy, et al. Bio-based porphyrins pyropheophorbide a and its Zn-complex as visible-light photosensitizers for free-radical photopolymerization. Polym. Chem., 2022,13, 1658-1671. https://doi.org/10.1039/D1PY01714D
