Desglymidodrine | CAS#3600-87-1 |

MedKoo Cat#: 592601 | Name: Desglymidodrine

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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Desglymidodrine is a Metabolite of midodrine (ST-1085). It is used in plasma of ascitic patients.

Chemical Structure

Desglymidodrine

CAS#3600-87-1 (free base)

Theoretical Analysis

MedKoo Cat#: 592601

Name: Desglymidodrine

CAS#: 3600-87-1 (free base)

Chemical Formula: C10H15NO3

Exact Mass: 197.1052

Molecular Weight: 197.23

Elemental Analysis: C, 60.90; H, 7.67; N, 7.10; O, 24.34

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 350.00	2 Weeks
10mg	USD 585.00	2 weeks

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Related CAS #

3600-87-1 (free base) 60407-53-6 (HCl)

Synonym

Desglymidodrine; Deglymidodrine; ST-1059; ST1059; ST 1059;

IUPAC/Chemical Name

alpha-(Aminomethyl)-2,5-dimethoxybenzenemethanol

InChi Key

VFRCNXKYZVQYLX-UHFFFAOYSA-N

InChi Code

InChI=1S/C10H15NO3/c1-13-7-3-4-10(14-2)8(5-7)9(12)6-11/h3-5,9,12H,6,11H2,1-2H3

SMILES Code

OC(CN)C1=CC(OC)=CC=C1OC

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.9001

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 197.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Ali AA, Al-Ghobashy MA, Farid SF, Kassem MA. Development and validation of LC-MS/MS assay for the determination of the prodrug Midodrine and its active metabolite Desglymidodrine in plasma of ascitic patients: Application to individualized therapy and comparative pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Jun 1;991:34-40. doi: 10.1016/j.jchromb.2015.03.032. Epub 2015 Apr 7. PubMed PMID: 25910235. 2: Barth T, Aleu J, Pupo MT, Bonato PS, Collado IG. HPLC analysis of midodrine and desglymidodrine in culture medium: evaluation of static and shaken conditions on the biotransformation by fungi. J Chromatogr Sci. 2013 May-Jun;51(5):460-7. doi: 10.1093/chromsci/bms163. Epub 2012 Oct 9. PubMed PMID: 23051063. 3: Patel DP, Nair S, Suhagia BN, Patel BM. A novel, sensitive and selective method of UPLC/MS-MS for rapid simultaneous determination of midodrine and its active metabolite desglymidodrine in human plasma: Application to support bioequivalence study in healthy human volunteers. J Pharm Biomed Anal. 2016 Nov 30;131:355-363. doi: 10.1016/j.jpba.2016.09.005. Epub 2016 Sep 5. PubMed PMID: 27639073. 4: Ali A, Farid S, Amin M, Kassem M, Al-Garem N, Al-Ghobashy M. Comparative Clinical Pharmacokinetics of Midodrine and Its Active Metabolite Desglymidodrine in Cirrhotic Patients with Tense Ascites Versus Healthy Volunteers. Clin Drug Investig. 2016 Feb;36(2):147-55. doi: 10.1007/s40261-015-0359-6. PubMed PMID: 26597181. 5: Barth T, Pupo MT, Borges KB, Okano LT, Bonato PS. Stereoselective determination of midodrine and desglymidodrine in culture medium: application to a biotransformation study employing endophytic fungi. Electrophoresis. 2010 May;31(9):1521-8. doi: 10.1002/elps.200900685. PubMed PMID: 20376815. 6: Akimoto M, Iida I, Itoga H, Miyata A, Kawahara S, Kohno Y. The in vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes. Eur J Drug Metab Pharmacokinet. 2004 Jul-Sep;29(3):179-86. PubMed PMID: 15537169. 7: Biaggioni I. New developments in the management of neurogenic orthostatic hypotension. Curr Cardiol Rep. 2014 Nov;16(11):542. doi: 10.1007/s11886-014-0542-z. Review. PubMed PMID: 25303896. 8: Leduc BE, Fournier C, Jacquemin G, Lepage Y, Vinet B, Hétu PO, Chagnon M. Midodrine in patients with spinal cord injury and anejaculation: A double-blind randomized placebo-controlled pilot study. J Spinal Cord Med. 2015 Jan;38(1):57-62. doi: 10.1179/2045772314Y.0000000225. Epub 2014 Jun 26. PubMed PMID: 24969635; PubMed Central PMCID: PMC4293534. 9: Wright RA, Kaufmann HC, Perera R, Opfer-Gehrking TL, McElligott MA, Sheng KN, Low PA. A double-blind, dose-response study of midodrine in neurogenic orthostatic hypotension. Neurology. 1998 Jul;51(1):120-4. PubMed PMID: 9674789. 10: Perazella MA. Efficacy and safety of midodrine in the treatment of dialysis-associated hypotension. Expert Opin Drug Saf. 2003 Jan;2(1):37-47. Review. PubMed PMID: 12904123. 11: Ali A, Farid S, Amin M, Kassem M, Al-Garem N. Clinical study on the therapeutic role of midodrine in non azotemic cirrhotic patients with tense ascites: a double-blind, placebo-controlled, randomized trial. Hepatogastroenterology. 2014 Oct;61(135):1915-24. PubMed PMID: 25713888. 12: McClellan KJ, Wiseman LR, Wilde MI. Midodrine. A review of its therapeutic use in the management of orthostatic hypotension. Drugs Aging. 1998 Jan;12(1):76-86. Review. PubMed PMID: 9467688. 13: Lamarre-Cliche M, Souich Pd, Champlain Jd, Larochelle P. Pharmacokinetic and pharmacodynamic effects of midodrine on blood pressure, the autonomic nervous system, and plasma natriuretic peptides: a prospective, randomized, single-blind, two-period, crossover, placebo-controlled study. Clin Ther. 2008 Sep;30(9):1629-38. doi: 10.1016/j.clinthera.2008.09.001. PubMed PMID: 18840368. 14: Wong LY, Wong A, Robertson T, Burns K, Roberts M, Isbister GK. Severe Hypertension and Bradycardia Secondary to Midodrine Overdose. J Med Toxicol. 2017 Mar;13(1):88-90. doi: 10.1007/s13181-016-0574-4. Epub 2016 Jul 14. PubMed PMID: 27417951; PubMed Central PMCID: PMC5330956. 15: Vaidyanathan S, Soni BM, Hughes PL. Midodrine: insidious development of urologic adverse effects in patients with spinal cord injury: a report of 2 cases. Adv Ther. 2007 Jul-Aug;24(4):712-20. PubMed PMID: 17901021. 16: Gutman LB, Wilson BJ. The Role of Midodrine for Hypotension Outside of the Intensive Care Unit. J Popul Ther Clin Pharmacol. 2017 Aug 23;24(3):e45-e50. doi: 10.22374/1710-6222.24.3.4. Review. PubMed PMID: 28873293. 17: Emms H, Farah G, Shine B, Boot C, Toole B, McFadden M, Lam L, Ou ZQ, Woollard G, Madhavaram H, Kyle C, Grossman AB. Falsely elevated plasma metanephrine in patients taking midodrine. Ann Clin Biochem. 2018 Jul;55(4):509-515. doi: 10.1177/0004563218755817. Epub 2018 Feb 21. PubMed PMID: 29357678.