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MedKoo Cat#: 598519 | Name: LD-473
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

LD-473 is a laser dye.

Chemical Structure

LD-473
LD-473
CAS#58721-74-7

Theoretical Analysis

MedKoo Cat#: 598519

Name: LD-473

CAS#: 58721-74-7

Chemical Formula: C17H19F3N2O

Exact Mass: 324.1449

Molecular Weight: 324.35

Elemental Analysis: C, 62.95; H, 5.90; F, 17.57; N, 8.64; O, 4.93

Price and Availability

Size Price Availability Quantity
200mg USD 385.00 2 Weeks
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Related CAS #
No Data
Synonym
LD-473; LD 473; LD473;
IUPAC/Chemical Name
1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-1,2,3,8-tetrahydro-7H-pyrrolo[3,2-g]quinolin-7-one
InChi Key
IOUKYANHUBKAIN-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H19F3N2O/c1-9-16(2,3)12-6-10-11(17(18,19)20)7-15(23)22(5)13(10)8-14(12)21(9)4/h6-9H,1-5H3
SMILES Code
O=C1N(C)C2=CC(N(C)C(C)C3(C)C)=C3C=C2C(C(F)(F)F)=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info
Product Data
Product Data
Instruction
View handling instruction
Biological target:
LD-473 is a laser dye.
In vitro activity:
The absorption and fluorescence spectra of 6,7,8,9-tetrahydro-6,8,9-trimethyl-4-(trifluoro methyl)-2H-pyrano[2,3-b][1,8]naphthyridin-2-one (LD-489) and 1,2,3,8-tetrahydro-1,2,3,3,8-pentamethyl-5-(trifluoromethyl)-7H-pyrrolo[3,2-g]quinolin-7-one (LD-473) have been recorded at room temperature in different solvents and 1,4-dioxane-acetonitrile solvent mixtures. The UV-Visible absorption spectra are less sensitive to solvent polarity than the corresponding fluorescence spectra in both the dyes which show pronounced solvatochromic effect. Reference: Spectrochim Acta A Mol Biomol Spectrosc. 2013 May;108:288-94. https://pubmed.ncbi.nlm.nih.gov/23501941/
In vivo activity:
TBD

Preparing Stock Solutions

The following data is based on the product molecular weight 324.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
1. Deepa HR, Thipperudrappa J, Suresh Kumar HM. Effect of solvents on the spectroscopic properties of LD-489 & LD-473: estimation of ground and excited state dipole moments by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2013 May;108:288-94. doi: 10.1016/j.saa.2013.01.084. Epub 2013 Feb 16. PMID: 23501941. 2. Aldwayyan AS, Masilamani V. Dual amplified spontaneous emission as evidence for superexciplex from the dye LD473. Spectrochim Acta A Mol Biomol Spectrosc. 2004 Oct;60(12):2891-5. doi: 10.1016/j.saa.2004.02.002. PMID: 15350926.
In vitro protocol:
1. Deepa HR, Thipperudrappa J, Suresh Kumar HM. Effect of solvents on the spectroscopic properties of LD-489 & LD-473: estimation of ground and excited state dipole moments by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2013 May;108:288-94. doi: 10.1016/j.saa.2013.01.084. Epub 2013 Feb 16. PMID: 23501941. 2. Aldwayyan AS, Masilamani V. Dual amplified spontaneous emission as evidence for superexciplex from the dye LD473. Spectrochim Acta A Mol Biomol Spectrosc. 2004 Oct;60(12):2891-5. doi: 10.1016/j.saa.2004.02.002. PMID: 15350926.
In vivo protocol:
TBD
1: Deepa HR, Thipperudrappa J, Suresh Kumar HM. Effect of solvents on the spectroscopic properties of LD-489 & LD-473: estimation of ground and excited state dipole moments by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2013 May;108:288-94. doi: 10.1016/j.saa.2013.01.084. Epub 2013 Feb 16. PubMed PMID: 23501941.