MedKoo Biosciences, Inc.
Tel:   +1-919-636-5577    Fax:   +1-919-980-4831    Email:   sales@medkoo.com
Search
Login Register
Search
MedKoo Cat#: 592590 | Name: NC 1100

Description:

WARNING: This product is for research use only, not for human or veterinary use.

NC 1100 is a calcium channel antagonist.

Chemical Structure

NC 1100
NC 1100
CAS#93035-33-7

Theoretical Analysis

MedKoo Cat#: 592590

Name: NC 1100

CAS#: 93035-33-7

Chemical Formula: C27H34Cl2N2O3

Exact Mass: 504.1946

Molecular Weight: 505.48

Elemental Analysis: C, 64.16; H, 6.78; Cl, 14.03; N, 5.54; O, 9.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
Bulk Inquiry
Related CAS #
No Data
Synonym
NC 1100; NC-1100; NC1100
IUPAC/Chemical Name
1-Piperazineethanol, alpha-(3,4-dimethoxyphenyl)-4-(diphenylmethyl)-, dihydrochloride
InChi Key
ZIGNSXDSBVYYFD-UHFFFAOYSA-N
InChi Code
InChI=1S/C27H32N2O3.2ClH/c1-31-25-14-13-23(19-26(25)32-2)24(30)20-28-15-17-29(18-16-28)27(21-9-5-3-6-10-21)22-11-7-4-8-12-22;;/h3-14,19,24,27,30H,15-18,20H2,1-2H3;2*1H
SMILES Code
OC(C1=CC=C(OC)C(OC)=C1)CN2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2.[H]Cl.[H]Cl
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 505.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Miyake N, Takayanagi I. Stereoselectivity of NC-1100, a Ca-entry blocker. Gen Pharmacol. 1990;21(2):261-3. PubMed PMID: 2332145. 2: Matsumura T, Furuichi H, Izumi J, Kamatsuka Y, Takei M, Nakata N, Ito S, Suda H, Kizaki K, Kurimoto T. [Effects of NC-1100, a calcium channel blocker, on experimental cerebral ischemia/anoxia in rodents]. Nihon Yakurigaku Zasshi. 1993 Mar;101(3):177-86. Japanese. PubMed PMID: 8486322. 3: Sadoshima S, Ibayashi S, Nakane H, Okada Y, Ooboshi H, Fujishima M. Attenuation of ischemic and postischemic damage to brain metabolism and circulation by a novel Ca2+ channel antagonist, NC-1100, in spontaneously hypertensive rats. Eur J Pharmacol. 1992 Dec 2;224(2-3):109-15. PubMed PMID: 1468503. 4: Hashimoto T, Kimori M, Nakamura Y, Kuriyama K. Effect of NC-1100 [1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol dihydrochloride] on gamma-aminobutyric acid (GABA) metabolism in rat brain: analysis using stroke-prone spontaneously hypertensive rat. Jpn J Pharmacol. 1989 Jun;50(2):131-9. PubMed PMID: 2770051. 5: Kuribara H, Tadokoro S. [Behavioral effects of NC-1100, 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol dihydrochloride--on ambulatory activity, discrete lever-press response and shuttle avoidance response in mice]. Nihon Yakurigaku Zasshi. 1989 Apr;93(4):245-53. Japanese. PubMed PMID: 2744654. 6: Tanabe K, Kinoshita Y, Tokuyoshi K, Houri D, Kimishima K. [Effects of 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl)ethanol dihydrochloride (NC-1100) on the central nervous system]. Nihon Yakurigaku Zasshi. 1991 Nov;98(5):357-68. Japanese. PubMed PMID: 1813367. 7: Miyake N, Wakamori M, Akaike N. A new type of Ca2+ channel blocker, NC-1100, inhibits the low- and high-threshold Ca2+ currents in the rat CNS neurons. Brain Res. 1992 Dec 11;598(1-2):215-20. PubMed PMID: 1486482. 8: Kushiku K, Ohba M, Araki T, Mikagi T, Katsuragi T, Furukawa T. Cardiovascular effects of 1-(3,4-dimethoxyphenyl)-2-(4-diphenylmethylpiperazinyl) ethanol and possible mechanisms involved. Arzneimittelforschung. 1989 Apr;39(4):458-63. PubMed PMID: 2751731. 9: Nishijo H, Kuze S, Ono T, Tabuchi E, Endo S, Kogure K. Calcium entry blocker ameliorates ischemic neuronal damage in monkey hippocampus. Brain Res Bull. 1992 Sep-Oct;29(3-4):519-24. PubMed PMID: 1393625. 10: Takayanagi I, Koike K, Miyake N, Sato R, Yamada K. Selectivity of cerebral vasodilators on basilar arteries. Gen Pharmacol. 1986;17(4):505-7. PubMed PMID: 3758658. 11: Nishijo H, Tabuchi E, Ono T, Fukuda M, Kuze S, Endo S. Physiological results of monkey brain ischemia, and protection by a calcium blocker. Brain Res Bull. 1995;37(1):89-101. PubMed PMID: 7606483. 12: Nomura Y, Yamakawa T, Nishioka K, Omura T, Miyake N, Masaki M, Nohira H. Synthesis and structure-activity relationships of 2-(4-benzhydryl-1-piperazinyl)-1-phenylethanols as new calcium blockers. Chem Pharm Bull (Tokyo). 1995 Feb;43(2):241-6. PubMed PMID: 7537178. 13: Miyake N, Fujita R, Ishikawa M, Takayanagi M, Takayanagi Y, Sasaki K. Reversal of multidrug resistance in human leukemia K562 by tamolarizine, a novel calcium antagonist. Jpn J Pharmacol. 2000 Mar;82(3):265-8. PubMed PMID: 10887958. 14: Tamura R, Nakada Y, Nishijo H, Miyake N, Ono T. Ameliorative effects of tamolarizine on place learning impairment induced by transient forebrain ischemia in rats. Brain Res. 2000 Jan 17;853(1):81-92. PubMed PMID: 10627311. 15: Izumiyama K, Kogure K. Prevention of delayed neuronal death in gerbil hippocampus by ion channel blockers. Stroke. 1988 Aug;19(8):1003-7. PubMed PMID: 2456632.