CU-115 is a toll-like receptor 8 (TLR8) antagonist. It is selective for TLR8 over TLR7. CU-115 inhibits increases in type I IFN transcriptional activity induced by the ssRNA nucleic acid ligands 3p-hpRNA or G3-YSD. It decreases TNF-α and IL-1β production induced by R-848.
MedKoo Cat#: 574326
Name: CU-115
CAS#: 2471982-20-2
Chemical Formula: C21H11F7INO2
Exact Mass: 568.9723
Molecular Weight: 569.22
Elemental Analysis: C, 44.31; H, 1.95; F, 23.36; I, 22.29; N, 2.46; O, 5.62
The following data is based on the product molecular weight 569.22 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
