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MedKoo Cat#: 592589 | Name: Rimiterol

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Rimiterol is a beta 2 stimulant, therefore affects the cardiovascular system less than isoproterenol, but its action is of shorter duration than that of albuterol.

Chemical Structure

Rimiterol
Rimiterol
CAS#32953-89-2

Theoretical Analysis

MedKoo Cat#: 592589

Name: Rimiterol

CAS#: 32953-89-2

Chemical Formula: C12H17NO3

Exact Mass: 223.1208

Molecular Weight: 223.27

Elemental Analysis: C, 64.55; H, 7.67; N, 6.27; O, 21.50

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
No Data
Synonym
Rimiterol
IUPAC/Chemical Name
1,2-Benzenediol, 4-(hydroxy-2-piperidinylmethyl)-, (R*,S*)-
InChi Key
IYMMESGOJVNCKV-JOYOIKCWSA-N
InChi Code
InChI=1S/C12H17NO3/c14-10-5-4-8(7-11(10)15)12(16)9-3-1-2-6-13-9/h4-5,7,9,12-16H,1-3,6H2/t9-,12+/m0/s1
SMILES Code
OC1=CC=C([C@@H](O)[C@H]2NCCCC2)C=C1O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 223.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Marlin GE, Turner P. Comparison of the beta2-adrenoceptor selectivity of rimiterol, salbutamol and isoprenaline by the intravenous route in man. Br J Clin Pharmacol. 1975 Feb;2(1):41-8. PubMed PMID: 10940; PubMed Central PMCID: PMC1402492. 2: Marlin GE, Turner P. The relative potencies and beta2-selectivities of intravenous rimiterol, salbutamol and isoprenaline in asthmatic patients. Int J Clin Pharmacol Biopharm. 1975 Jul;12(1-2):158-69. PubMed PMID: 240780. 3: Phillips PJ, Vedig AE, Jones PL, Chapman MG, Collins M, Edwards JB, Smeaton TC, Duncan BM. Metabolic and cardiovascular side effects of the beta 2-adrenoceptor agonists salbutamol and rimiterol. Br J Clin Pharmacol. 1980 May;9(5):483-91. PubMed PMID: 6104976; PubMed Central PMCID: PMC1429961. 4: Paterson IC, Willey RF, Shotter MV, Crompton GK. Further studies of rimiterol and salbutamol administered by intermittent positive-pressure ventilation, and an important observation on the technique of using the Bennett ventilator. Br J Clin Pharmacol. 1977 Oct;4(5):605-9. PubMed PMID: 20919; PubMed Central PMCID: PMC1429151. 5: Morton AR, Scott CA, Fitch KD. Rimiterol and the prevention of exercise-induced asthma. J Allergy Clin Immunol. 1989 Jan;83(1):61-5. PubMed PMID: 2563270. 6: Tarala RA, Martyn V, Paterson JW. Effect of intravenous injection of rimiterol in asthma. Br J Clin Pharmacol. 1981 Sep;12(3):333-40. PubMed PMID: 6117302; PubMed Central PMCID: PMC1401816. 7: Paterson IC, Willey RF, Shotter V, Grant IW, Crompton GK. Objective and subjective comparisons of terbutaline and rimiterol bronchodilator aerosols. Br J Dis Chest. 1975 Oct;69(0):267-72. PubMed PMID: 1106746. 8: Muittari A. A comparison of rimiterol and salbutamol by inhalation at high and low dose in asthmatic patients. Respiration. 1978;35(3):165-72. PubMed PMID: 25466. 9: Ydreborg SO, Svedmyr N, Thiringer G. Comparison of rimiterol and terbutaline, given by aerosol, in a long-term study. Scand J Respir Dis. 1977 Apr;58(2):117-24. PubMed PMID: 16339. 10: Bowman WC, Rodger IW. Actions of the sympathomimetic bronchodilator, rimiterol (R798), on the cardiovascular, respiratory and skeletal muscle systems of the anaesthetized cat. Br J Pharmacol. 1972 Aug;45(4):574-83. PubMed PMID: 5085231; PubMed Central PMCID: PMC1665966. 11: Cooke NJ, Kerr JA, Willey RF, Hoare MV, Grant IW, Cromptom GK. Response to rimiterol and salbutamol aerosols administered by intermittent positive-pressure ventilation. Br Med J. 1974 May 4;2(5913):250-2. PubMed PMID: 4597119; PubMed Central PMCID: PMC1610528. 12: Eriksson NE, Lindgren SB. The rapidity of bronchodilatation. A comparison of isoprenaline, terbutaline and rimiterol. Scand J Respir Dis. 1978 Feb;59(1):30-6. PubMed PMID: 26113. 13: Stephens JD, Hayward RP, Ead H, Adams L, Spurrell RA. Comparative peripheral and coronary haemodynamic effects of rimiterol and isoprenaline. Br J Clin Pharmacol. 1978 Aug;6(2):163-70. PubMed PMID: 28135; PubMed Central PMCID: PMC1429410. 14: Marlin GE, Hartnett BJ, Berend N. Comparative potencies and beta2-adrenoreceptor selectivities of rimiterol and salbutamol aerosols. Br J Clin Pharmacol. 1977 Feb;4(1):77-9. PubMed PMID: 14660; PubMed Central PMCID: PMC1428978. 15: Blackhall MI, Macartney B, O'Donnell SR. The acute effects of the administration of rimiterol aerosol in asthmatic children. Br J Clin Pharmacol. 1978 Jul;6(1):59-62. PubMed PMID: 27205; PubMed Central PMCID: PMC1429394. 16: Monie RD, Rocchiccioli KM, White JP. Sustained release aminophylline in asthma and its interaction with rimiterol. Br J Clin Pharmacol. 1982 Jul;14(1):110-2. PubMed PMID: 6125198; PubMed Central PMCID: PMC1427568. 17: Marlin GE, Turner P. Intravenous treatment with rimiterol and salbutamol in asthma. Br Med J. 1975 Jun 28;2(5973):715-9. PubMed PMID: 1139193; PubMed Central PMCID: PMC1673959. 18: Pinder RM, Brogden RN, Speight TM, Avery GS. Rimiterol: a review of its pharmacological properties and therapeutic efficacy in asthma. Drugs. 1977 Aug;14(2):81-104. Review. PubMed PMID: 19226. 19: Bianco S, Kamburoff PL, Prime FJ. Comparison between the bronchodilator and cardiovascular effects of inhaling 0.5 mg. rimiterol ('Pulmadil') and 0.2 mg. salbutamol. Curr Med Res Opin. 1975;3(1):30-5. PubMed PMID: 1116382. 20: Pedersen JT. [Rimiterol (Pulmadil)]. Ugeskr Laeger. 1976 Nov 1;138(45):2816-7. Danish. PubMed PMID: 10658.

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