Synonym
MRT199665; MRT-199665; MRT 199665;
IUPAC/Chemical Name
7-[(1S)-4-Hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethyl-2-(methylsulfonyl)-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
InChi Key
LZUYOYKXEXENTQ-ZDUSSCGKSA-N
InChi Code
InChI=1S/C18H19N3O4S/c1-18(2)12-9-19-17(26(3,24)25)20-15(12)21(16(18)23)13-8-7-11-10(13)5-4-6-14(11)22/h4-6,9,13,22H,7-8H2,1-3H3/t13-/m0/s1
SMILES Code
O=C1C(C)(C)C2=CN=C(S(=O)(C)=O)N=C2N1[C@H]3CCC4=C3C=CC=C4O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>2 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
373.43
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
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2: Darling NJ, Toth R, Arthur JS, Clark K. Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. Biochem J. 2017 Feb 15;474(4):521-537. doi: 10.1042/BCJ20160646. Epub 2016 Dec 5. PubMed PMID: 27920213; PubMed Central PMCID: PMC5290485.
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