MedKoo Cat#: 558431 | Name: Benziodarone
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Benziodarone is a vasodilator. Results suggest that benziodarone has an amiodarone-like action.

Chemical Structure

Benziodarone
Benziodarone
CAS#68-90-6

Theoretical Analysis

MedKoo Cat#: 558431

Name: Benziodarone

CAS#: 68-90-6

Chemical Formula: C17H12I2O3

Exact Mass: 517.8900

Molecular Weight: 518.09

Elemental Analysis: C, 39.41; H, 2.33; I, 48.99; O, 9.26

Price and Availability

Size Price Availability Quantity
1g USD 350.00 2 Weeks
5g USD 950.00 2 Weeks
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Related CAS #
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Synonym
Benziodarone; Carofam; Corofam; Coronal-crinos; Dila-Vasal; Dilacoron;
IUPAC/Chemical Name
2-Ethyl-3-benzofuranyl 4-hydroxy-3,5-diiodophenyl ketone
InChi Key
CZCHIEJNWPNBDE-UHFFFAOYSA-N
InChi Code
InChI=1S/C17H12I2O3/c1-2-13-15(10-5-3-4-6-14(10)22-13)16(20)9-7-11(18)17(21)12(19)8-9/h3-8,21H,2H2,1H3
SMILES Code
O=C(C1=C(CC)OC2=CC=CC=C12)C3=CC(I)=C(O)C(I)=C3
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 518.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Xanthopoulos B, Koutras DA, Boukis MA, Piperingos GD, Kitsopanides J, Souvatzoglou A, Moulopoulos SD. The effect of benziodarone on the thyroid hormone levels and the pituitary-thyroid axis. J Endocrinol Invest. 1986 Aug;9(4):337-9. PubMed PMID: 3491129. 2: Moulopoulos SD, Koutras DA, Stamatelopoulos S, Souvatzoglou A, Piperingos GD, Philippou G. Comparison of the effect of amiodarone and benziodarone on thyroxine metabolism and surface ECG. Endocrinol Exp. 1989 Dec;23(4):269-78. PubMed PMID: 2620658. 3: Perez-Ruiz F, Gomez-Ullate P, Amenabar JJ, Zarraga S, Calabozo M, Herrero-Beites AM, Nolla JM. Long-term efficacy of hyperuricaemia treatment in renal transplant patients. Nephrol Dial Transplant. 2003 Mar;18(3):603-6. PubMed PMID: 12584286. 4: Franco A, Jimenez L, Torralba J, Ortega E, Trigueros M, Olivares J. Acute uric acid nephropathy by overdosage of benziodarone in a renal transplant recipient. Nephron. 2002;92(3):746-7. PubMed PMID: 12372973. 5: Lafuente Gormaz C, Gallego Page JC, Llamas Fuentes F. [Pharmacological interaction between flecainide and benziodarone]. Rev Esp Cardiol. 2003 Jun;56(6):631-2. Spanish. PubMed PMID: 12783743. 6: VITOLO A. [Influence of benziodarone on various enzyme activities in vitro]. Boll Soc Ital Biol Sper. 1963 Apr 30;39:493-5. Italian. PubMed PMID: 13997523. 7: WAREMBOURG H, STALNIKIEWICZ G. [THE THERAPEUTIC VALUE OF BENZIODARONE IN ANGINA PECTORIS]. Lille Med. 1964 Mar;9:297-305. French. PubMed PMID: 14141059. 8: BLAKE S, KEELAN D. A TRIAL OF BENZIODARONE (CARDIVIX) IN ANGINA PECTORIS. J Ir Med Assoc. 1964 Feb;54:42-3. PubMed PMID: 14117208. 9: Magos L, Cikrt M, Snowden R. The dependence of biliary methylmercury secretion on liver GSH and ligandin. Biochem Pharmacol. 1985 Feb 1;34(3):301-5. PubMed PMID: 3871612. 10: MEWISSEN A. [Clinical note concerning a recent coronary dilator: benziodarone]. Rev Med Liege. 1962 Jan 15;17:43-6. French. PubMed PMID: 14473077. 11: DAVIES P, ORAM S, CURWEN MP. Double-blind trial of benziodarone in angina pectoris. Br Med J. 1963 Aug 10;2(5353):359-61. PubMed PMID: 14025425; PubMed Central PMCID: PMC1872469. 12: HARRISON MT, CAMERON AJ. IODINE-INDUCED HYPOTHYROIDISM DUE TO BENZIODARONE (CARDIVIX). Br Med J. 1965 Mar 27;1(5438):840. PubMed PMID: 14258850; PubMed Central PMCID: PMC2166280. 13: Brzozowska-Jurkowska AM. [Effect of benziodarone and benzbromarone on the uric acid level in the blood and urine and on the incidence of gout attacks]. Reumatologia. 1980;18(3):287-92. Polish. PubMed PMID: 6999575. 14: DEWAR HA, NEWELL DJ. CLINICAL TRIAL OF BENZIODARONE (CARDIVIX), ORALLY AND INTRAVENOUSLY, IN ANGINA. Scott Med J. 1964 Dec;9:526-30. PubMed PMID: 14243617. 15: Heim J, Ramée A, Massart C, Allannic H. [Gynecomastia and iodine induced thyrotoxicosis during a benziodarone treatment (author's transl)]. Sem Hop. 1980 Mar 18-25;56(11-12):572-4. French. PubMed PMID: 6245463. 16: MENDEL D, WINTERTON M. Effect of benziodarone on myocardial blood flow in rabbit. Br Med J. 1963 Aug 10;2(5353):358-9. PubMed PMID: 13934808; PubMed Central PMCID: PMC1872500. 17: Vatakuti S, Pennings JL, Gore E, Olinga P, Groothuis GM. Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices. Chem Res Toxicol. 2016 Mar 21;29(3):342-51. doi: 10.1021/acs.chemrestox.5b00491. Epub 2016 Mar 9. PubMed PMID: 26881866. 18: D'HEER H. [Clinical use of benziodarone in the treatment of angina pectoris]. Belg Tijdschr Geneesk. 1961 Dec 1;17:1226-38. Dutch. PubMed PMID: 13883003. 19: BEKAERT J, DELTOUR G, BROEKHUYSEN J. [Research on the benzofuran series. III. Study of the thyroid function in man during the administration of an iodized bensofuran derivative (Benziodarone)]. Arch Int Pharmacodyn Ther. 1961 Jul 1;132:339-48. French. PubMed PMID: 13688762. 20: André LJ, Delprat J. [Value of a pharmaceutic preparation combining benziodarone with an alkalinizator for the treatment of gout]. Sem Hop Ther. 1974 May-Jun;50(5-6):376-80. French. PubMed PMID: 4612715.