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MedKoo Cat#: 461272 | Name: RG 12525

Description:

WARNING: This product is for research use only, not for human or veterinary use.

RG 12525 is a competitive and orally effective antagonist of the peptidoleukotrienes, LTC4, LTD4 and LTE4.

Chemical Structure

RG 12525
RG 12525
CAS#120128-20-3

Theoretical Analysis

MedKoo Cat#: 461272

Name: RG 12525

CAS#: 120128-20-3

Chemical Formula: C25H21N5O2

Exact Mass: 423.1695

Molecular Weight: 423.47

Elemental Analysis: C, 70.91; H, 5.00; N, 16.54; O, 7.56

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
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Synonym
RG 12525; RG-12525; RG12525;
IUPAC/Chemical Name
2-((4-((2-((1H-tetrazol-5-yl)methyl)benzyl)oxy)phenoxy)methyl)quinoline
InChi Key
JELDFLOBXROBFH-UHFFFAOYSA-N
InChi Code
InChI=1S/C25H21N5O2/c1-2-7-20(19(6-1)15-25-27-29-30-28-25)16-31-22-11-13-23(14-12-22)32-17-21-10-9-18-5-3-4-8-24(18)26-21/h1-14H,15-17H2,(H,27,28,29,30)
SMILES Code
C1(COC2=CC=C(OCC3=CC=CC=C3CC4=NN=NN4)C=C2)=NC5=CC=CC=C5C=C1
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 423.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Carlton RA, Difeo TJ, Powner TH, Santos I, Thompson MD. Preparation and characterization of polymorphs for an LTD4 antagonist, RG 12525. J Pharm Sci. 1996 May;85(5):461-7. PubMed PMID: 8742935. 2: Van Inwegen RG, Nuss GW, Carnathan GW. Antagonism of peptidoleukotrienes and inhibition of systemic anaphylaxis by RG 12525 in guinea pigs. Life Sci. 1989;44(12):799-807. PubMed PMID: 2539543. 3: Welch MJ, Nelson HS, Paull BR, Smith JA, Feiss G, Tobey RE. Effect of RG 12525, a new leukotriene antagonist, on pulmonary function of asthmatic adults. Ann Allergy. 1994 Apr;72(4):348-52. PubMed PMID: 8154635. 4: Bonnefoi MS, Kelley MF, Wells RE, Sanders JE, Jayyosi Z, Beys E, Kornbrust DJ, Langloss JM. Subchronic toxicity studies with the leukotriene D4 antagonist RG 12525. Fundam Appl Toxicol. 1995 Nov;28(1):129-38. PubMed PMID: 8566477. 5: Stevens JC, Fayer JL, Cassidy KC. Characterization of 2-[[4-[[2-(1H-tetrazol-5-ylmethyl)phenyl]methoxy]methyl]quinoline N-glucuronidation by in vitro and in vivo approaches. Drug Metab Dispos. 2001 Mar;29(3):289-95. PubMed PMID: 11181497. 6: Wahedna I, Wisniewski AS, Tattersfield AE. Effect of RG 12525, an oral leukotriene D4 antagonist, on the airway response to inhaled leukotriene D4 in subjects with mild asthma. Br J Clin Pharmacol. 1991 Oct;32(4):512-5. PubMed PMID: 1958449; PubMed Central PMCID: PMC1368616. 7: Carnathan GW, Sweeney D, Travis J, Van Inwegen RG. The effect of RG 12525 on leukotriene D4-mediated pulmonary responses in guinea pigs. Agents Actions. 1989 Jun;27(3-4):316-8. PubMed PMID: 2801315. 8: Fayer JL, Zannikos PN, Stevens JC, Luo Y, Sidhu R, Kirkesseli S. Lack of correlation between in vitro inhibition of CYP3A-mediated metabolism by a PPAR-gamma agonist and its effect on the clinical pharmacokinetics of midazolam, an in vivo probe of CYP3A activity. J Clin Pharmacol. 2001 Mar;41(3):305-16. PubMed PMID: 11269571. 9: Huang FC, Galemmo RA Jr, Johnson WH Jr, Poli GB, Morrissette MM, Mencel JJ, Warus JD, Campbell HF, Nuss GW, Carnathan GW, et al. Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 2. Effects of an additional phenyl ring on receptor affinity. J Med Chem. 1990 Apr;33(4):1194-200. PubMed PMID: 2157010. 10: Sakakibara H, Hirose K, Okawara S. [Peptidoleukotriene receptor antagonists in asthma therapy]. Nihon Rinsho. 1996 Nov;54(11):3049-55. Review. Japanese. PubMed PMID: 8950953.

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Desipramine Free Base

Desipramine Free Base