Synonym
MT81 Mycotoxin; MT-81 Mycotoxin; MT 81 Mycotoxin
IUPAC/Chemical Name
9,10-Anthracenedione, 1,5-dihydroxy-3-methyl-8-((2,6,7,7a-tetrahydro-4H-furo(3,2-c)pyran-4-yl)oxy)-
InChi Key
TUSQXSZBOGDCBU-UHFFFAOYSA-N
InChi Code
InChI=1S/C22H18O7/c1-10-8-12-17(14(24)9-10)21(26)19-16(3-2-13(23)18(19)20(12)25)29-22-11-4-6-27-15(11)5-7-28-22/h2-4,8-9,15,22-24H,5-7H2,1H3
SMILES Code
O=C1C2=C(C(O)=CC=C2OC3C4=CCOC4CCO3)C(C5=CC(C)=CC(O)=C15)=O
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.9001
Preparing Stock Solutions
The following data is based on the
product
molecular weight
394.38
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Choudhury SM, Gupta M, Majumder UK. Toxicological potential of mycotoxin MT81 and its benzoylated derivative on testicular spermatogenesis and steroidogenesis in mature male Wistar albino rats. Toxicol Mech Methods. 2011 Jun;21(5):426-33. doi: 10.3109/15376516.2011.552535. Epub 2011 Mar 21. PMID: 21417635.
2: Choudhury SM, Gupta M, Majumder UK. Antineoplastic activities of MT81 and its structural analogue in Ehrlich ascites carcinoma-bearing Swiss Albino mice. Oxid Med Cell Longev. 2010 Jan-Feb;3(1):61-70. doi: 10.4161/oxim.3.1.10495. PMID: 20716929; PMCID: PMC2835890.
3: Choudhury S, Rana MP, Chatterjee TK, Mazumder UK, Gupta M. Antimicrobial activities of mycotoxin MT81 and its structural derivatives. Indian J Exp Biol. 1992 Feb;30(2):140-1. PMID: 1521863.
4: Gupta M, Majumdar UK, Ray MR, Mukhopadhayay DK. Inhibition of experimental murine tumors by MT81, a new mycotoxin from Penicillium nigricans. Neoplasma. 1997;44(5):329-33. PMID: 9473795.
5: Mitra M, Mandal AK, Chatterjee TK, Das N. Targeting of mannosylated liposome incorporated benzyl derivative of Penicillium nigricans derived compound MT81 to reticuloendothelial systems for the treatment of visceral leishmaniasis. J Drug Target. 2005 Jun;13(5):285-93. doi: 10.1080/10611860500233306. PMID: 16199372.
6: Liao L, Zhang X, Lou Y, Zhou C, Yuan Q, Gao J. Discovery of Three New Phytotoxins from the Fungus Aspergillus nidulans by Pathway Inactivation. Molecules. 2019 Jan 31;24(3):515. doi: 10.3390/molecules24030515. PMID: 30708999; PMCID: PMC6384659.
7: Majumdar UK, Gupta M, Chowdhury S, Saha AK. Antileishmanial activities of mycotoxin MT 81 and its derivatives. Indian J Exp Biol. 1993 Nov;31(11):888-90. PMID: 8112762.
