IUPAC/Chemical Name
alpha-((Isopropylamino)methyl)-p-nitrobenzyl alcohol
InChi Key
UAORFCGRZIGNCI-UHFFFAOYSA-N
InChi Code
InChI=1S/C11H16N2O3/c1-8(2)12-7-11(14)9-3-5-10(6-4-9)13(15)16/h3-6,8,11-12,14H,7H2,1-2H3
SMILES Code
O=[N+](C1=CC=C(C=C1)C(O)CNC(C)C)[O-]
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
Preparing Stock Solutions
The following data is based on the
product
molecular weight
224.26
Batch specific molecular weights may vary
from batch to batch
due to the degree of hydration, which will
affect the solvent
volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass |
1 mg |
5 mg |
10 mg |
| 1 mM |
1.15 mL |
5.76 mL |
11.51 mL |
| 5 mM |
0.23 mL |
1.15 mL |
2.3 mL |
| 10 mM |
0.12 mL |
0.58 mL |
1.15 mL |
| 50 mM |
0.02 mL |
0.12 mL |
0.23 mL |
1: Lemmens-Gruber R, Zilberszac A, Heistracher P. Arrhythmogenic effect of beta-adrenoceptor-blocking drugs in Purkinje fibres of guinea-pig hearts. Arch Int Pharmacodyn Ther. 1996 Jan-Feb;331(1):46-58. PubMed PMID: 8896710.
2: Ragazzi E, Froldi G, Fassina G. Resveratrol activity on guinea pig isolated trachea from normal and albumin-sensitized animals. Pharmacol Res Commun. 1988 Dec;20 Suppl 5:79-82. PubMed PMID: 2907791.
3: Ichiyama M, Sada S, Takahashi Y, Sada H, Ban T. Effects of bucumolol, nadolol and nifenalol on maximum upstroke velocity of action potential in guinea pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1986 Mar;332(3):297-304. PubMed PMID: 2872598.
4: Alinovi A, Branchetti A, Barella PA. [Iatrogenic dermatoses caused by beta-blocking drugs]. G Ital Dermatol Venereol. 1983 Nov-Dec;118(6):341-8. Review. Italian. PubMed PMID: 6143722.
5: Nishimura T, Kita S, Abiko Y. Effects of 1-(4-nitrophenyl)-2-isopropylaminoethanol (INPEA) and propranolol and their dextro-isomers on hemodynamic and metabolic responses to isoproterenol in dogs. J Pharmacol Exp Ther. 1983 Aug;226(2):595-602. PubMed PMID: 6688273.
6: Pandhi P, Sharma PL. Potentiating effect of (+) INPEA on prostaglandin analogue evoked contractions of isolated rat uterus. Indian J Med Res. 1983 Mar;77:391-4. PubMed PMID: 6688239.
7: Capasso F, Sorrentino L. Sensitization by (+) Inpea of rat stomach strip contraction induced by PGE2 or pleural exudates. Pharmacol Res Commun. 1981 Jul;13(7):705-9. PubMed PMID: 6944701.
8: Sánchez-Cuadrado MC, Boada J, Bayo JM. [Action of propranolol, nifenalol, and pindolol on the lipolytic effect of adrenaline in the rat epididymis]. Arch Farmacol Toxicol. 1981 Apr;7(1):181-2. Spanish. PubMed PMID: 6895689.
9: Garg SK, Rajkumar K. Effect of (+) INPEA, (+) sotalol and deoxysotalol on the in vitro production of prostaglandins E and F by the rat uterus. Indian J Med Res. 1980 Apr;71:641-4. PubMed PMID: 6893041.
10: Harms HH, Zaagsma J, de Vente J. Differentiation of beta-adrenoceptors in right atrium, diaphragm and adipose tissue of the rat, using stereoisomers of propranolol, alprenolol, nifenalol and practolol. Life Sci. 1977 Jul 1;21(1):123-8. PubMed PMID: 196150.
11: Rabast U, Kasper H, Schönborn J, Knechtel B. [Blood glucose concentration and insulin activity in serum after administration of the beta receptor blockader nifenalol-HC1 (INPEA). Studies in metabolically healthy people and diabetics]. Ther Ggw. 1977 Jun;116(6):1162-74. German. PubMed PMID: 578017.
12: Hasslacher C, Wahl P, Riemer G. [Influence of the beta-receptor blocker nifenalol on insulin secretion in normal subjects and diabetic patients (author's transl)]. Arzneimittelforschung. 1977 Feb;27(2):426-9. German. PubMed PMID: 577165.
13: Bartsch W, Dietmann K, Leinert H, Sponer G. Cardiac action of carazolol and methypranol in comparison with other beta-receptor blockers. Arzneimittelforschung. 1977;27(5):1022-6. PubMed PMID: 18157.
