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MedKoo Cat#: 598474 | Name: Thionin chloride

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Thionin chloride is a coloring agent.

Chemical Structure

Thionin chloride
Thionin chloride
CAS#581-64-6

Theoretical Analysis

MedKoo Cat#: 598474

Name: Thionin chloride

CAS#: 581-64-6

Chemical Formula: C12H10ClN3S

Exact Mass: 0.0000

Molecular Weight: 263.74

Elemental Analysis: C, 54.65; H, 3.82; Cl, 13.44; N, 15.93; S, 12.16

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Related CAS #
No Data
Synonym
Thionine; NSC 9591; NSC-9591; NSC9591; Thionin chloride; C.I. 52000;
IUPAC/Chemical Name
3,7-diaminophenothiazin-5-ium chloride
InChi Key
ANRHNWWPFJCPAZ-UHFFFAOYSA-M
InChi Code
InChI=1S/C12H10N3S.ClH/c13-7-1-3-9-11(5-7)16-12-6-8(14)2-4-10(12)15-9;/h1-6H,13-14H2;1H/q+1;/p-1
SMILES Code
NC1=CC2=[S+]C3=C(C=CC(N)=C3)N=C2C=C1.[Cl-]
Appearance
Solid powder
Purity
>90% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 263.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Ma M, Miao Z, Zhang D, Du X, Zhang Y, Zhang C, Lin J, Chen Q. Highly-ordered perpendicularly immobilized FWCNTs on the thionine monolayer-modified electrode for hydrogen peroxide and glucose sensors. Biosens Bioelectron. 2015 Feb 15;64:477-84. doi: 10.1016/j.bios.2014.09.057. Epub 2014 Sep 28. PubMed PMID: 25286355. 2: Lozano HJ, García B, Busto N, Leal JM. Interaction of thionine with triple-, double-, and single-stranded RNAs. J Phys Chem B. 2013 Jan 10;117(1):38-48. doi: 10.1021/jp307840c. Epub 2012 Dec 19. PubMed PMID: 23206123. 3: Zasonská B, Čadková M, Kovářová A, Bílková Z, Korecká L, Horák D. Thionine-Modified Poly(glycidyl methacrylate) Nanospheres as Labels of Antibodies for Biosensing Applications. ACS Appl Mater Interfaces. 2015 Nov 11;7(44):24926-31. doi: 10.1021/acsami.5b08469. Epub 2015 Nov 3. PubMed PMID: 26479119. 4: Lin Y, Zhou Q, Lin Y, Tang D, Niessner R, Knopp D. Enzymatic hydrolysate-induced displacement reaction with multifunctional silica beads doped with horseradish peroxidase-thionine conjugate for ultrasensitive electrochemical immunoassay. Anal Chem. 2015 Aug 18;87(16):8531-40. doi: 10.1021/acs.analchem.5b02253. Epub 2015 Jul 28. PubMed PMID: 26181887. 5: Zhao Z, Chen H, Ma L, Liu D, Wang Z. A label-free electrochemical impedance aptasensor for cylindrospermopsin detection based on thionine-graphene nanocomposites. Analyst. 2015 Aug 21;140(16):5570-7. doi: 10.1039/c5an00704f. PubMed PMID: 26111280. 6: Manivel P, Anandakumar S, Ilanchelian M. Exploring the interaction of the photodynamic therapeutic agent thionine with bovine serum albumin: multispectroscopic and molecular docking studies. Luminescence. 2015 Sep;30(6):729-39. doi: 10.1002/bio.2812. Epub 2014 Nov 25. PubMed PMID: 25423948. 7: Su S, Zou M, Zhao H, Yuan C, Xu Y, Zhang C, Wang L, Fan C, Wang L. Shape-controlled gold nanoparticles supported on MoS₂ nanosheets: synergistic effect of thionine and MoS₂ and their application for electrochemical label-free immunosensing. Nanoscale. 2015 Dec 7;7(45):19129-35. doi: 10.1039/c5nr05614d. Epub 2015 Nov 2. PubMed PMID: 26524543. 8: Sun Z, Fu H, Deng L, Wang J. Redox-active thionine-graphene oxide hybrid nanosheet: one-pot, rapid synthesis, and application as a sensing platform for uric acid. Anal Chim Acta. 2013 Jan 25;761:84-91. doi: 10.1016/j.aca.2012.11.057. Epub 2012 Dec 5. PubMed PMID: 23312318. 9: Shanmugaraj K, Anandakumar S, Ilanchelian M. Exploring the biophysical aspects and binding mechanism of thionine with bovine hemoglobin by optical spectroscopic and molecular docking methods. J Photochem Photobiol B. 2014 Feb 5;131:43-52. doi: 10.1016/j.jphotobiol.2014.01.001. Epub 2014 Jan 11. PubMed PMID: 24486625. 10: Rahimnejad M, Najafpour GD, Ghoreyshi AA, Talebnia F, Premier GC, Bakeri G, Kim JR, Oh SE. Thionine increases electricity generation from microbial fuel cell using Saccharomyces cerevisiae and exoelectrogenic mixed culture. J Microbiol. 2012 Aug;50(4):575-80. doi: 10.1007/s12275-012-2135-0. Epub 2012 Aug 25. PubMed PMID: 22923104. 11: Li Z, Chen L, He F, Bu L, Qin X, Xie Q, Yao S, Tu X, Luo X, Luo S. Square wave anodic stripping voltammetric determination of Cd²⁺ and Pb²⁺ at bismuth-film electrode modified with electroreduced graphene oxide-supported thiolated thionine. Talanta. 2014 May;122:285-92. doi: 10.1016/j.talanta.2014.01.062. Epub 2014 Jan 31. PubMed PMID: 24720997. 12: Zhang Z, Luo L, Zhu L, Ding Y, Deng D, Wang Z. Aptamer-linked biosensor for thrombin based on AuNPs/thionine-graphene nanocomposite. Analyst. 2013 Sep 21;138(18):5365-70. doi: 10.1039/c3an01006f. Epub 2013 Jul 23. PubMed PMID: 23877321. 13: Gao F, Gao C, He S, Wang Q, Wu A. Label-free electrochemical lead (II) aptasensor using thionine as the signaling molecule and graphene as signal-enhancing platform. Biosens Bioelectron. 2016 Jul 15;81:15-22. doi: 10.1016/j.bios.2016.01.096. Epub 2016 Feb 17. PubMed PMID: 26913503. 14: Ghica ME, Brett CM. Poly(brilliant green) and poly(thionine) modified carbon nanotube coated carbon film electrodes for glucose and uric acid biosensors. Talanta. 2014 Dec;130:198-206. doi: 10.1016/j.talanta.2014.06.068. Epub 2014 Jul 5. PubMed PMID: 25159399. 15: Guo L, Zhang Q, Huang Y, Han Q, Wang Y, Fu Y. The application of thionine-graphene nanocomposite in chiral sensing for Tryptophan enantiomers. Bioelectrochemistry. 2013 Dec;94:87-93. doi: 10.1016/j.bioelechem.2013.09.002. Epub 2013 Sep 13. PubMed PMID: 24084594. 16: Wang X, Wang M, Zhang Y, Miao X, Huang Y, Zhang J, Sun L. Electrochemical biosensor based on enzyme substrate as a linker: Application for aldolase activity with pectin-thionine complex as recognization element and signal amplification probe. Biosens Bioelectron. 2016 Sep 15;83:91-6. doi: 10.1016/j.bios.2016.04.009. Epub 2016 Apr 5. PubMed PMID: 27107145. 17: Gayathri CH, Mayuri P, Sankaran K, Kumar AS. An electrochemical immunosensor for efficient detection of uropathogenic E. coli based on thionine dye immobilized chitosan/functionalized-MWCNT modified electrode. Biosens Bioelectron. 2016 Aug 15;82:71-7. doi: 10.1016/j.bios.2016.03.062. Epub 2016 Mar 24. PubMed PMID: 27040944. 18: Han J, Ma J, Ma Z. One-step synthesis of graphene oxide-thionine-Au nanocomposites and its application for electrochemical immunosensing. Biosens Bioelectron. 2013 Sep 15;47:243-7. doi: 10.1016/j.bios.2013.03.032. Epub 2013 Mar 22. PubMed PMID: 23584387. 19: Qin X, Yin Y, Yu H, Guo W, Pei M. A novel signal amplification strategy of an electrochemical aptasensor for kanamycin, based on thionine functionalized graphene and hierarchical nanoporous PtCu. Biosens Bioelectron. 2016 Mar 15;77:752-8. doi: 10.1016/j.bios.2015.10.050. Epub 2015 Oct 23. Review. PubMed PMID: 26513281. 20: Zhou Q, Li G, Zhang Y, Zhu M, Wan Y, Shen Y. Highly Selective and Sensitive Electrochemical Immunoassay of Cry1C Using Nanobody and π-π Stacked Graphene Oxide/Thionine Assembly. Anal Chem. 2016 Oct 4;88(19):9830-9836. Epub 2016 Sep 22. PubMed PMID: 27617345.