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MedKoo Cat#: 592540 | Name: Trehalose
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Description:

WARNING: This product is for research use only, not for human or veterinary use.

Trehalose prevents sciatic nerve damage to and apoptosis of Schwann cells of streptozotocin-induced diabetic C57BL/6J mice.

Chemical Structure

Trehalose
Trehalose
CAS#99-20-7

Theoretical Analysis

MedKoo Cat#: 592540

Name: Trehalose

CAS#: 99-20-7

Chemical Formula: C12H22O11

Exact Mass: 342.1162

Molecular Weight: 342.30

Elemental Analysis: C, 42.11; H, 6.48; O, 51.41

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Synonym
Trehalose; NSC 2093; NSC-2093; NSC2093
IUPAC/Chemical Name
alpha-D-Glucopyranoside, alpha-D-glucopyranosyl
InChi Key
HDTRYLNUVZCQOY-LIZSDCNHSA-N
InChi Code
InChI=1S/C12H22O11/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12/h3-20H,1-2H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-/m1/s1
SMILES Code
O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 342.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Santamaria C, Biegas KJ, Kim CY, Cabral J, Lee JR, Swarts BM, Siegrist MS. Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonical SNARE interaction. bioRxiv [Preprint]. 2024 Dec 16:2024.12.16.627577. doi: 10.1101/2024.12.16.627577. PMID: 39763847; PMCID: PMC11702582. 2: Hedjazi S, Miyamoto T, Ahn JE, Sitcheran RM, Amrein H. Glucose-6-phosphatase is required for organelle reorganization, energy metabolism and motility of Drosophila sperm. bioRxiv [Preprint]. 2024 Dec 17:2024.12.02.626170. doi: 10.1101/2024.12.02.626170. PMID: 39763814; PMCID: PMC11702525. 3: Kim D, Lee SE. Proteomic evaluation of pathways associated with phosphine- induced mitochondrial dysfunction and resistance mechanisms in Tribolium castaneum against phosphine fumigation: Whole and partial proteome identification. Ecotoxicol Environ Saf. 2025 Jan 2;289:117652. doi: 10.1016/j.ecoenv.2024.117652. Epub ahead of print. PMID: 39755090. 4: Yan Y, Cao M, Ma J, Suo J, Bai X, Ge W, Lü X, Zhang Q, Chen J, Cui S, Yang B. Mechanisms of thermal, acid, desiccation and osmotic tolerance of Cronobacter spp. Crit Rev Food Sci Nutr. 2025 Jan 3:1-23. doi: 10.1080/10408398.2024.2447304. Epub ahead of print. PMID: 39749527. 5: Groh JS, Vik DC, Davis M, Monroe JG, Stevens KA, Brown PJ, Langley CH, Coop G. Ancient structural variants control sex-specific flowering time morphs in walnuts and hickories. Science. 2025 Jan 3;387(6729):eado5578. doi: 10.1126/science.ado5578. Epub 2025 Jan 3. PMID: 39745948. 6: Darwiche N, Dufresne C, Chartier A, Claude B, Colas C, Fougère L, Sebban M, Lucchesi ME, Le Floch S, Nehmé R. Glycolipid and Lipopeptide Biosurfactants: Structural Classes and Characterization-Rhamnolipids as a Model. Crit Rev Anal Chem. 2024 Dec 29:1-21. doi: 10.1080/10408347.2024.2441428. Epub ahead of print. PMID: 39734093. 7: Du C, Hu H, Zhu G, Duan Z, Shen Y, Lin L, Lu J, Zheng Z. Microencapsulation of Pickering nanoemulsions containing walnut oil stabilized using soy protein- curcumin composite nanoparticles: Fabrication and evaluation of a novel plant- based milk substitute. Food Chem. 2024 Dec 26;470:142654. doi: 10.1016/j.foodchem.2024.142654. Epub ahead of print. PMID: 39733619. 8: García JE, Pagnussat LA, Amenta MB, Casanovas EM, Diaz PR, Labarthe MM, Martino MV, Groppa MD, Creus CM, Maroniche GA. Maize drought protection by Azospirillum argentinense Az19 requires bacterial trehalose accumulation. Appl Microbiol Biotechnol. 2024 Dec 27;108(1):543. doi: 10.1007/s00253-024-13391-0. PMID: 39729258; PMCID: PMC11680609. 9: Maity M, Allay MB, Ali MH, Basu S, Singh S. Effect of different artificial tears on tear film parameters in dry eye disease. Optom Vis Sci. 2024 Dec 24. doi: 10.1097/OPX.0000000000002206. Epub ahead of print. PMID: 39729080. 10: Xiao X, Liu Q, Zhang Q, Yan Z, Cai D, Li X. Exogenous Trehalose Assists Zygosaccharomyces rouxii in Resisting High-Temperature Stress Mainly by Activating Genes Rather than Entering Metabolism. J Fungi (Basel). 2024 Dec 5;10(12):842. doi: 10.3390/jof10120842. PMID: 39728338; PMCID: PMC11677697. 11: Li F, Yang R, Xu J, Xu G, Wu Y. Detecting N-Phenyl-2-Naphthylamine, L-Arabinose, D-Mannose, L-Phenylalanine, L-Methionine, and D-Trehalose via Photocurrent Measurement. Gels. 2024 Dec 9;10(12):808. doi: 10.3390/gels10120808. PMID: 39727566; PMCID: PMC11675501. 12: Jin J, Zeng Y, Gao X, Li J, Cui T, Xu X, Yang G, Zhang G, Hao C, Zhang J. Trehalose and Mannitol Based Lyoprotetion of Taq DNA Polymerase for Cold-chain- free Long-term Storage. J Pharm Sci. 2024 Dec 24:S0022-3549(24)00624-5. doi: 10.1016/j.xphs.2024.12.022. Epub ahead of print. PMID: 39725227. 13: Izaguirre-Pérez N, Ligero G, Aguilar-Solana PA, Carrillo-Ávila JA, Rodriguez-Reyes CR, Biunno I, Aguilar-Quesada R, Catalina P. Trehalose Cryopreservation of Human Mesenchymal Stem Cells from Cord Tissue. Biopreserv Biobank. 2024 Dec 26. doi: 10.1089/bio.2024.0025. Epub ahead of print. PMID: 39723442. 14: Sakai Y, Asa M, Hirose M, Kusuhara W, Fujiwara N, Tamashima H, Ikazaki T, Oka S, Kuraba K, Tanaka K, Yoshiyama T, Nagae M, Hoshino Y, Motooka D, Van Rhijn I, Lu X, Ishikawa E, Moody DB, Kato T, Inuki S, Hirai G, Yamasaki S. A conserved human CD4+ T cell subset recognizing the mycobacterial adjuvant, trehalose monomycolate. J Clin Invest. 2024 Dec 24:e185443. doi: 10.1172/JCI185443. Epub ahead of print. PMID: 39718834. 15: Song LY, Guo ZY, Liu JY, Xu CQ, Li J, Zhang LD, Song SW, Zheng HL. In silico analysis of trehalose biosynthesis genes provides clues to reveal its roles in Avicennia marina adaptation to tidal submergence. Plant Physiol Biochem. 2024 Dec 18;219:109420. doi: 10.1016/j.plaphy.2024.109420. Epub ahead of print. PMID: 39718284. 16: Wang Z, Song S, Zhang H, Liu X, A Siegel R, Calvin Sun C, Wang C. Impact of solid content on the bulk properties of lyophilized powders. Int J Pharm. 2024 Dec 20;670:125081. doi: 10.1016/j.ijpharm.2024.125081. Epub ahead of print. PMID: 39710308. 17: Hong Z, Kong Y, Chen J, Guo R, Huang Q. Collaborative stabilizing effect of trehalose and myofibrillar protein on high internal phase emulsions: Improved freeze-thaw stability and 3D printability. Food Chem. 2024 Dec 19;469:142564. doi: 10.1016/j.foodchem.2024.142564. Epub ahead of print. PMID: 39709922. 18: Eh TJ, Jiang Y, Jiang M, Li J, Lei P, Ji X, Kim HI, Zhao X, Meng F. The role of trehalose metabolism in plant stress tolerance. J Adv Res. 2024 Dec 19:S2090-1232(24)00603-9. doi: 10.1016/j.jare.2024.12.025. Epub ahead of print. PMID: 39708962. 19: Wu H, Li H, Li Z, Liu X, Li Q, Cheng M, Gong J. Interfacial engineering- based colonization of biofilms on polyethylene terephthalate (PET) surfaces: Implications for whole-cell biodegradation of microplastics. Sci Total Environ. 2024 Dec 20;958:178002. doi: 10.1016/j.scitotenv.2024.178002. Epub ahead of print. PMID: 39708756. 20: Li C, Chen Z, Chen L, Wang G. The adaptation mechanism of desert soil cyanobacterium Chroococcidiopsis sp. to desiccation. Plant Physiol Biochem. 2024 Dec 16;219:109414. doi: 10.1016/j.plaphy.2024.109414. Epub ahead of print. PMID: 39708702.