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MedKoo Cat#: 592537 | Name: Dicarboxidine

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Dicarboxidine is a chromogen for the detection of barbiturates, meprobamate and some other sedatives on thin-layer chromatograms. Dicarboxidine is a safe substitute for conventional benzidine type reagents. Dicarboxidine can be used for detection of N-Boc-protected amino acids and peptides by TLC. Dicarboxidine is a substrate for peroxidases as horse radish peroxidase.

Chemical Structure

Dicarboxidine
Dicarboxidine
CAS#34915-18-9 (free base)

Theoretical Analysis

MedKoo Cat#: 592537

Name: Dicarboxidine

CAS#: 34915-18-9 (free base)

Chemical Formula: C20H24N2O6

Exact Mass: 388.1634

Molecular Weight: 388.42

Elemental Analysis: C, 61.85; H, 6.23; N, 7.21; O, 24.71

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.
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Related CAS #
56455-90-4 (HCl) 34915-18-9 (free base)
Synonym
Dicarboxidine
IUPAC/Chemical Name
Butanoic acid, 4,4'-((4,4'-diamino(1,1'-biphenyl)-3,3'-diyl)bis(oxy))bis-
InChi Key
NUBOMXHHTQFVBI-UHFFFAOYSA-N
InChi Code
InChI=1S/C20H24N2O6/c21-15-7-5-13(11-17(15)27-9-1-3-19(23)24)14-6-8-16(22)18(12-14)28-10-2-4-20(25)26/h5-8,11-12H,1-4,9-10,21-22H2,(H,23,24)(H,25,26)
SMILES Code
NC1=CC=C(C2=CC=C(N)C(OCCCC(O)=O)=C2)C=C1OCCCC(O)=O
Appearance
Solid powder
Purity
>98% (or refer to the Certificate of Analysis)
Shipping Condition
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility
Soluble in DMSO
Shelf Life
>3 years if stored properly
Drug Formulation
This drug may be formulated in DMSO
Stock Solution Storage
0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code
2934.99.03.00
More Info

Preparing Stock Solutions

The following data is based on the product molecular weight 388.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
1: Chen R, Li TM, Merrick H, Parrish RF, Bruno V, Kwong A, Stiso C, Litman DJ. An internal clock reaction used in a one-step enzyme immunochromatographic assay of theophylline in whole blood. Clin Chem. 1987 Sep;33(9):1521-5. PubMed PMID: 3304712. 2: Paul KG, Ohlsson PI, Jönsson NA. The assay of peroxidases by means of dicarboxidine on enzyme-linked immunosorbent assay level. Anal Biochem. 1982 Jul 15;124(1):102-7. PubMed PMID: 7125217. 3: Swolin B, Roberts D, Waldenström J. Quantitative determination of plasma hemoglobin using dicarboxidine. Clin Chim Acta. 1982 Jun 3;121(3):389-91. PubMed PMID: 7105402. 4: Svahn CM, Gyllander J. Dicarboxidine [gamma, gamma'-(4,4'-diamino-3,3'-biphenylylenedioxy)dibutyric acid] dihydrochloride as a chromogen for the detection of barbiturates, meprobamate and some other sedatives on thin-layer chromatograms. J Chromatogr. 1979 Feb 11;170(1):294-5. PubMed PMID: 544628. 5: Jönsson NA, Gröningsson K, Pavlu B, Vessman J, Westlund LE. gamma,gamma'-(4,4'-Diamino-3,3'-biphenylylenedioxy)dibutyric acid (dicarboxidine) a safer substitute for benzidine type chromogens. Arzneimittelforschung. 1979;29(2):187-93. PubMed PMID: 582129. 6: Pliss GB, Vol'fson NI. [Possible carcinogenic action of chromogen dicarboxidine]. Vopr Onkol. 1979;25(7):43-8. Russian. PubMed PMID: 483680.