Laurifoline | CAS#7224-61-5 | NF-κB inhibitor

MedKoo Cat#: 598453 | Name: Laurifoline

Description:

WARNING: This product is for research use only, not for human or veterinary use.

Laurifoline is a potential NF-κB inhibitor.

Chemical Structure

Laurifoline

CAS#7224-61-5

Theoretical Analysis

MedKoo Cat#: 598453

Name: Laurifoline

CAS#: 7224-61-5

Chemical Formula: C20H24NO4

Exact Mass: 342.1700

Molecular Weight: 342.41

Elemental Analysis: C, 70.15; H, 7.07; N, 4.09; O, 18.69

Price and Availability

This product is currently not in stock but may be available through custom synthesis. To ensure cost efficiency, the minimum order quantity is 1 gram. The estimated lead time is 2 to 4 months, with pricing dependent on the complexity of the synthesis (typically high for intricate chemistries). Quotes for quantities below 1 gram will not be provided. To request a quote, please click the button below. Note: If this product becomes available in stock in the future, pricing will be listed accordingly.

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Related CAS #

No Data

Synonym

Laurifoline;

IUPAC/Chemical Name

(S)-1,9-dihydroxy-2,10-dimethoxy-6,6-dimethyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-6-ium

InChi Key

ZDVDVLRYVOZWMP-AWEZNQCLSA-O

InChi Code

InChI=1S/C20H23NO4/c1-21(2)6-5-11-9-17(25-4)20(23)19-13-10-16(24-3)15(22)8-12(13)7-14(21)18(11)19/h8-10,14H,5-7H2,1-4H3,(H-,22,23)/p+1/t14-/m0/s1

SMILES Code

C[N+]1(C)CCC2=CC(OC)=C(O)C3=C2[C@]1([H])CC4=CC(O)=C(OC)C=C34

Appearance

Solid powder

Purity

>98% (or refer to the Certificate of Analysis)

Shipping Condition

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility

Soluble in DMSO

Shelf Life

>3 years if stored properly

Drug Formulation

This drug may be formulated in DMSO

Stock Solution Storage

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code

2934.99.03.00

More Info

Instruction

View handling instruction

Preparing Stock Solutions

The following data is based on the product molecular weight 342.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

1: Sun D, Han Y, Wang W, Wang Z, Ma X, Hou Y, Bai G. Screening and identification of Caulis Sinomenii bioactive ingredients with dual-target NF-κB inhibition and β(2-) AR agonizing activities. Biomed Chromatogr. 2016 Nov;30(11):1843-1853. doi: 10.1002/bmc.3761. Epub 2016 Jun 16. PubMed PMID: 27187693. 2: KIKKAWA I, TOMITA M. Studies on the alkaloids of menispermaceous plants. CXXXIV. Alkaloids of Cocculus laurifolius DC. (suppl. 8), syntheses of di-coclanoline and di-laurifoline. Pharm Bull. 1956 Aug;4(4):230-6. PubMed PMID: 13378942. 3: Tomko J, Awad AT, Beal JL, Doskotch RW. Isolation of candicine chloride, laurifoline chloride, and xanthoxyletin from the bark of Zanthoxylum elephantiasis. J Pharm Sci. 1968 Feb;57(2):329-30. PubMed PMID: 5641685. 4: Yi L, Liang ZT, Peng Y, Yao X, Chen HB, Zhao ZZ. Tissue-specific metabolite profiling of alkaloids in Sinomenii Caulis using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry. J Chromatogr A. 2012 Jul 27;1248:93-103. doi: 10.1016/j.chroma.2012.05.058. Epub 2012 May 24. PubMed PMID: 22721764. 5: Cheng P, Ma YB, Yao SY, Zhang Q, Wang EJ, Yan MH, Zhang XM, Zhang FX, Chen JJ. Two new alkaloids and active anti-hepatitis B virus constituents from Hypserpa nitida. Bioorg Med Chem Lett. 2007 Oct 1;17(19):5316-20. Epub 2007 Aug 16. PubMed PMID: 17723297.